Báo cáo khoa học: Pfkfb3 is transcriptionally upregulated in diabetic mouse liver through proliferative signals docx

... that Pfkfb3 gene expression is increased in streptozotocin-induced diabetic mouse liver. The Pfkfb3 ⁄ -3566 promoter construct linked to the luciferase reporter gene was delivered to the liver ... This promoter was upregulated in streptozotocin-induced diabetic mouse liver compared with transfected healthy cohorts. In addition, increases were observed in Pfkfb3...

Ngày tải lên: 30/03/2014, 01:20

... as insulin receptor sub- strates and adiponectin [8,9], resulting in obesity-related insulin resistance [11–13]. In an in vitro model of ER stress induced by proteasome inhibition, the stress induced ... adaptor protein that interacts with adiponectin receptors, insulin and adiponectin signaling are now considered to be linked in the peripheral organs of insulin action, such as the l...

Ngày tải lên: 22/03/2014, 21:21

... finer grained semantics with respect to other languages (for instance en in Spanish is vague between the Contact and Container senses of the Location, whereas in English it is finer grained, ... ended up going to the (financial-institution OR river-shore), whatever this object might be!, instead of a) going to the financial- institution OR b) going to the river-shore. In thi...

Ngày tải lên: 08/03/2014, 06:20

... utility of modelling in the study of T. brucei glycolysis has even led to the coining of a new strategy for the investigation of metabolism: computer experimentation [11]. This is inten- ded to ... a secondary role for hexokinase and the remainder of main- chain glycolysis having only minimal relevance. This pattern has previously been observed in a study of glycolytic flux control in...

Ngày tải lên: 17/03/2014, 11:20

... that is dominant in the deceptive corpus, and thus likely to be a characteristic of the texts in this corpus. Finally, a score significantly lower than 1 indicates a class that is dominant in the ... truth/deception, and it is not bound to a particular topic. 5 Identifying Dominant Word Classes in Deceptive Text In order to gain a better understanding of the char- acteristics o...

Ngày tải lên: 31/03/2014, 00:20

... also determine IS using domain knowledge. 3 Information Structure Information structure (IS) is an inherent aspect of meaning; it is important for establishing co- herence and getting the intended ... Background/Focus partitioning dis- tinguishes between alternatives in context. Our approach to assigning IS is similar to Pre- vost's in assigning IS according to the precedin...

Ngày tải lên: 31/03/2014, 20:20

... FEBS Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells Michalis D. Mantzaris 1 , Epameinondas ... TAG synthesis was initially hindered following stearate administration and was completely interrupted at longer incubation periods. Interestingly, the interruption of TAG synthe- sis...

Ngày tải lên: 14/02/2014, 22:20

... His, His41, in NirF by Ala abolished binding of the heme to the protein. Known distal heme-binding residues, such as Met, Lys or Cys [18,19], were substituted for His41 in NirF. No changes in ... with the C-terminal d 1 heme-containing domain of cytochrome cd 1 . Strikingly, the axial ligand of iron in d 1 heme in P. pantotrophus cd 1 (His200) is conserved in NirF (His41); this...

Ngày tải lên: 15/02/2014, 01:20

... specificity for PDI is nonexistent. Bacitracin is also used medicinally to prevent infections in small cuts and burns and to treat gastrointestinal infections. In addition, it is used as an animal ... pancreatic trypsin inhibitor (BPTI) refolding assay. BPTI is a widely studied protein con- taining three disulfides in the native form. In a gluta- thione-based refolding buffer, B...

Ngày tải lên: 16/02/2014, 14:20

... degrades mRNAs harboring premature termination codons. In humans, nonsense-mediated mRNA is linked to splicing, but in Drosophila and also in Caenorhabditis elegans, it occurs independently of introns. A ... as was discussed by Javier F. Caceres (Edinburgh, UK). The trans-acting factors involved include both serine- arginine (SR) and heterogeneous nuclear ribonucleo- protein (hnRNP) A...

Ngày tải lên: 19/02/2014, 02:20