Báo cáo khoa học: Alanine screening of the intracellular loops of the human bradykinin B2 receptor – effects on receptor maintenance, G protein activation and internalization pdf
Báo cáo khoa học: Alanine screening of the intracellular loops of the human bradykinin B2 receptor – effects on receptor maintenance, G protein activation and internalization pdf
... 349 1–3 503 ª 2009 The Authors Journal compilation ª 2009 FEBS 3503 Alanine screening of the intracellular loops of the human bradykinin B2 receptor – effects on receptor maintenance, G protein activation ... depend on the cell type and the receptor expression levels. Although the processes of signaling and regulation of human B2R are, in general, fairly well understood, the knowl-edge of the molecular ... self -maintenance, for the recruitment and acti-vation of the G protein, or for the initiation of the desensitization process (i.e. for relaying the informationto GRKs and arrestins that the receptor...
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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"
... proportion of errors, patient outcomes arising from the error and types of error. The proportion of MEs reduced following the introduction of CPOE. There was also some evidence that a learning curveoccurred ... details of MEs and the totalnumber of drugs prescribed daily during the data collectionperiods, during the course of his normal chart review.Results The total proportion of MEs was significantly ... existedspecifying the tenets of good practice, including the avoid-ance of the use of abbreviations.An ME was defined to have occurred when a prescribing deci-sion or prescription writing process...
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... long-range1H–13C correlation wasdetected between the carbonyl carbon of the serine and the d-CH2 of the hOrn, which constitutes the DKP.Therefore, putting all these long-range connectionstogether, ... on the investigation of erythrochelin-mediated angiotensin-converting enzyme inhibition,aiming to assign a bioactivity going beyond ironchelation. On the basis of the results obtained in the ... characterization of these compounds isgrowing and may result in the synthesis of specificinhibitors based on the structure of the pathogensiderophore [16].A promising approach for the isolation of secondarymetabolites,...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... primer, 5¢-GACCAGCTTCATGTGGCCATCGTGCAGGTT-3¢; reverseprimer, 5¢-CACGATGGCCACATGAAGCT-3¢) to PCR-amplify the coding regions of these domains in the panCgene from E. coli genomic DNA [44]. The amplified ... along the protein backbone for Glu5–Glu20 of nPS.Fig. S2. Secondary structure distribution of nPS insolution along with the sequence, short-range NOEpattern, and secondary chemical shifts of 13Ca ... Model 45, 110 1–1 108.36 Sarkhel S & Desiraju GR (2004) N–H O, O–H O, and C–H O hydrogen bonds in protein ligandcomplexes: strong and weak interactions in molecularrecognition. Protein Struct...
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Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf
... Location of the interchain disulfide bonds of the fourth component of human complement (C4): evidence based on the liber-ation of fragments secondary to thiol–disulfide inter-change reactions. ... proteolysis destroys the information on the size of the protein and the connectivities of the pep-tide fragments, but it has no size limit for protein digestion. In contrast, the top-down approach ... 625 6–6 268 ª 2007 The Authors Journal compilation ª 2007 FEBSdestroying information on their backbone location.However, the energetic (‘nonergodic’) dissociation of ECD is localized on the backbone,...
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Tài liệu Báo cáo khoa học: Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf
... 5¢-CGACTCGAGAAAAGAGCGCAAGAGCCAGTCAA-3¢ and 5¢-CGACTCGAGAAAAGAGCTGTCACGGGAGTTCCT-3¢ wereused for amplification of the elafin and the trappin cDNA5¢ end, respectively, and reverse primer 5¢CGAGCGGCCGCCCCTCTCACTGGGGAAC-3¢ ... reverse primer 5¢CGAGCGGCCGCCCCTCTCACTGGGGAAC-3¢ was used for the common3¢ end of elafin and trappin. Oligonucleotides 5¢-GGTGCGCCTTGTTGAATCC-3¢ (forward) and 5¢ -GGATTCAACAAGGCGCACC-3¢ (reverse) ... concen-trations of native and oxidized elafin and trappin on the activity of a constant concentration of NE and Fig. 1. Inhibition of neutrophil elastase (NE) and proteinase 3 (Pr3)by native and N-chlorosuccinimide-oxidized...
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Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc
... 102 103 C S R / G W E G F A Y / W-TGT TCT AGG GGC TGG GAG GGG TTT GCT TAC TGG-Fig. 1. Genetic rearrangements and hypermutations in the CDR3 loops of mAb4E11. The nucleotide and amino-acid residues ... rearrangedvariable V genes, the variability of the junctional sites and the addition or deletion of nucleotides create newcodons at the junctions of the genetic segments, the heavy and light chains ... the numbering of the amino-acid sequences of immunoglobulins and the definition of their CDR loops, as described from 1997 [13]. The number-ing and definition of the L-CDR3 and H-CDR3 loops of mAb4E11...
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Tài liệu Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure pptx
... extension. The primers were32P end-labeledoligonucleotides with the following sequences: 5¢-GCGGGAGTTTCACGCCACCAAGATCC-3¢ (MMTV, 10pmol) and 5¢-GGCTTGGTGATGCCCTGGATGTTATCC-3¢ (H4, loading control, ... of glucocorti-coid ligands and in the presence of androgen, progesterone and their respective nuclear receptors (Fig. 1A) [3]. Sixtranslationally positioned nucleosomes (A–F) cover thisregion ... transcriptional activation and chromatinopening through inhibition of the deacetylation of histones.However, our results and those of others show that TSA-induced changes in expression and chromatin...
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Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx
... 43 3–4 43 ª 2005 FEBS 435 The collision induced negative ion mass spectrum(MS ⁄ MS) of the [(M-H) – -SO3] – ion of eugenin isshown in Fig. 4. There are a number of backbonecleavages in negative ... to euge-nin, indicating that eugenin is indeed acting throughCCK2receptors.To further investigate the interaction of eugenin withCCK2receptors, we investigated the effect of eugenin on ... compounds. Figure 2 showsa typical HPLC separation. MS and MS ⁄ MS data on the components of all HPLC fractions indicate the presence of a variety of lipid, sugar and phosphateFig. 1. The young of Macropus...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... (5¢-TGGTACTCGAGCAATTTCTGAAGGTATCGAAG-3¢) and pyk2 (5¢-GGAAGGATCCTTGTGTTTTTCTCCTATAATG-3¢) and downstream to pyk using primer pyk3 (5¢-GGAAGGATCCTTTGTCAATTAATGATCTTAAAAC-3¢) and pyk4(5¢-CTAGTCTAGATGAGCTCCAGAAGCTTCC-3¢) ... CP-pyk(5¢-ACGACTAGTGGATCCATNNNNNAGTTTATTCTTGACANNNNNNNNNNNNNNTGRTATAATNNNNAAGTAATAAAATATTCGGAGGAATTTTGAAATGAATAAACGTGTAAAAATCG-3¢)(N¼ A, T, G, C) and pyk-back (5¢-CTCTACATGCATTTCAACAATAGGGCCTGTC-3¢) ... placing all the genesinvolved in the pathway in the same operon; the cellcan then respond quickly to changes in the environ-ment by changing the expression of only a few genes and using the protein- synthesizing...
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