Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx

Báo cáo khoa học: Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77 potx

... 5¢-ATGGTGGGAATGGGTCAGAAG-3¢ and 5¢-CACGCAGCTCATTGTAGAAGG-3¢. Another primer pairused for SerpinA3 was ACTas5-ACTas3: 5¢-GAATCCACCAGCTACATCCA-3¢ and 5¢-GTGCCCTCCTCAAATACATCA-3¢.Western blot assayThe cells ... pcDNA3.1-GST-Nur77plasmid. pSilencer-shNur77 was prepared by overlappingstrategy with primers 5¢-gacGGATCCgcagtccagccatgctcctttcaagagaaggagcatg-3¢ (with BamHI), 5¢-cggAAGCTTtATCGATccaaaaaacagtccagccatgctccttctcttg-3¢ ... 5¢-CTAATCTCTTCCTCCAAAAAGCACACAGA-3¢ for St-182 and St-93/-182, 5¢-AGAAATTATCATCTTTTCCAGTCCGAGA-3¢for St-93 and St-93/-182, and 5¢-TGGTCTTGAACTCCTCGTGATCTGCCCA-3¢ for Lst-595.pcDNA3.1-Nur77 expression plasmid...

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf

... Tsubouchi H, Naka D, Takahashi K,Okigaki M, Arakaki N, Nakayama H, Hirono S,Sakiyama O, Takahashi K et al. (1989) Molecularcloning and sequence analysis of cDNA for human hepatocyte growth factor. ... Shimomura T, Miyazawa K, Komiyama Y, HiraokaH, Naka D, Morimoto Y & Kitamura N (1995)Activation of hepatocyte growth factor by twohomologous proteases, blood-coagulation factor XIIaand hepatocyte ... MINIREVIEW Hepatocyte growth factor activator (HGFA): a serineprotease that links tissue injury to activation of hepatocyte growth factor Keiji MiyazawaDepartment of Biochemistry, Interdisciplinary...

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1) doc

... substratespro -hepatocyte growth factor and pro -macrophage-stimulating protein. AbbreviationsEGF, epidermal growth factor; HAI, hepatocyte growth factor activator inhibitor; HGFA, hepatocyte growth ... (2009) Hepatocyte growth factor activator is a serum activator of single-chain precursor macro-phage-stimulating protein. FEBS J 276, 3481–3490.3 Kataoka H & Kawaguchi M (2010) Hepatocyte growth factor ... Conformational states of the HGFA active site region. (A) Cartoon of HGFA and HAI-1 domain architectures. HGFA contains a heavychain (A- chain) disulﬁde-linked to the protease domain (B-chain)....

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt

... of human plasma kallikrein and factor XIa by protein Cinhibitor. Biochemistry 27, 4231–4237.8 Wakita T, Hayashi T, Tamaru H, Nishioka J, AkitaN, Asanuma K, Kamada H, Gabazza EC, Ido M,Kawamura ... regeneration.AbbreviationsAPC, activated protein C; BrdU, bromodeoxyuridine; HAI, hepatocyte growth factor activator inhibitor; HGF, hepatocyte growth factor; HGFA, hepatocyte growth factor activator; hPCI-Tg, human protein ... plasma of normal individuals. Thus, PCImay play a role as a potent inhibitor of HGFA and APC in plasma and ⁄ orat the sites of tissue injury in the regulation of tissue regeneration.AbbreviationsAPC,...

Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): pathophysiological functionsin vivo potx

... human kallik-rein 1-related peptidases. FEBS J 275, 1003–1017.26 Kawaguchi M, Orikawa H, Baba T, Fukushima T &Kataoka H (2009) Hepatocyte growth factor activator is a serum activator of single-chain ... plasma of healthyindividuals is around 40 nm ( 4 lgÆmL)1) [10], indi-cating its relative abundance as a plasma protein. Theactivated form of HGFA is also detectable in humanplasma and serum, ... (1998)Induction of hepatocyte growth factor and its activator in rat brain with permanent middle cerebral arteryocclusion. Brain Res 799, 311–316.16 Nagashima M, Hasegawa J, Kato K, Yamazaki J,Nishigai...

Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx

... activator of single-chain precursor macrophage-stimulating protein Makiko Kawaguchi, Hiroshi Orikawa, Takashi Baba, Tsuyoshi Fukushima and Hiroaki KataokaSection of Oncopathology and Regenerative ... proteinases(cell surface activator) , such as matriptase [9]. Matriptase is also a potent activator of pro-HGF/SF [12,30]. The second pathway is mediatedby humoral activators that are generated ... domain [5]. MSP is synthesized and secreted by hepatocytes [6] and circu-lates in plasma as a single-chain precursor (pro-MSP)Keywordsactivation; hepatocyte growth factor activator; macrophage-stimulating...

Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf

... JW & Condra C (1992) An inhi-bitor of collagen-stimulated platelet activation from thesalivary glands of the Haementeria of cinalis leech. I.Identiﬁcation, isolation, and characterization. ... substanceshave been discovered that inhibit platelet adhesionand activation. Three such molecules, LAPP (anapproximately 13 kDa leech antiplatelet protein isola-ted from Haementeria of cinalis) ... process of hemostasis has allowed theleech to continue its alimentary habit of hemato-phagy. The presence of anticoagulants in the salivaryglands of the leech, Hirudo medicinalis, was originallydiscovered...

Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf

... recording at80 °C for 30 s. Similarly b-actin cDNA was also ampliﬁedusing primers b-actin F (sense) (5¢-AGAAAATCTGGCACCACACC-3¢) and b-actin R (antisense) (5¢-TAG-CACAGCCTGGATAGCAA-3¢), and served ... puriﬁcation and characterization of an alkalinedipeptide naphthylamidase (Arg–Arg–NAase) of the ratskin. Arch Klin Exp Dermatol 236, 267–281.2 de Bersaques J (1972) Peptidases and naphthylamidasesin ... ﬁbroblast growth factors. Lab Invest79, 407–416.31 Kitange G, Tsunoda K, Anda T, Nakamura S, Yasuna-ga A, Naito S & Shibata S (2000) Immunohistochemicalexpression of Ets-1 transcription factor...

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... Aichi Cancer Center Hospital, Nagoya, JapanIdentiﬁcation of epidermal growth factor, epidermal growth factor receptor and ERBB family proteinsEpidermal growth factor (EGF) was originally isolatedby ... otheractivated genes in lung cancers are also discussed.AbbreviationsALK, anaplastic lymphoma kinase; BAC, bronchioloalveolar cell carcinoma; EGF, epidermal growth factor; EGFR, epidermal growth ... have four functional domains: anextracellular ligand-binding domain; a transmembranedomain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2]. The extracellulardomain...

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... lung can-cer with epidermal growth factor receptor mutations. BrJ Cancer 95, 998–1004.16 Sutani A, Nagai Y, Udagawa K, Uchida Y, KoyamaN, Murayama Y, Tanaka T, Miyazawa H, Nagata M,Kanazawa ... epidermal growth factor receptor gene mutations. Lung Cancer 64,314–318.22 Morita S, Okamoto I, Kobayashi K, Yamazaki K,Asahina H, Inoue A, Hagiwara K, Sunaga N,Yanagitani N, Hida T et al. (2009) ... muta-tion in patients with non-small cell lung cancer.J Thorac Oncol 2, 22–28.18 Sunaga N, Tomizawa Y, Yanagitani N, Iijima H,Kaira K, Shimizu K, Tanaka S, Suga T, Hisada T,Ishizuka T et al....

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