Báo cáo khoa học: Piecing together the structure of retroviral integrase, an important target in AIDS therapy pptx
Báo cáo khoa học: Piecing together the structure of retroviral integrase, an important target in AIDS therapy pptx
... observed in HIV-1 IN. Thus, the number of amino acids forming the linker in ASV IN is much smaller than in HIV-1 IN, although the distance between the start and end points of these linkers is ... complexes of the IN- binding domain (IBD) of LEDGF with the CCD of HIV-1 IN [35], and with the NTD–CCD of HIV-2 IN [59]. The IBD used in these experiments...
Ngày tải lên: 29/03/2014, 23:20
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... an important role in the regulation of cellular pro- cesses in plants and mammals. Moreover, they are an essential tool in the synthesis of phospholipids and phospholipid analogs. Knowledge of ... constants in the ranges of 0.1 mm and 10–20 mm can be confirmed. The stability of PLDa2 proved to be sub- stantially reduced in the presence of calcium ions, wit...
Ngày tải lên: 19/02/2014, 02:20
Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
... NOHA [10], nothing is known about the thermodynamics and kinetics of the binding of guanidines and N-hydroxy- guanidines to iNOS. Removal of the a-amino or a-carboxylate moiety of l-Arg has important effects ... for the synthesis of the guanidines and N-hydroxyguanidines used in this study. DL-G thanks Zhi-Qiang Wang, Chin-Chuan Wei and Koustubh Panda (Cleveland Clinic...
Ngày tải lên: 16/03/2014, 22:20
Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... addition of ISP and Qcr10p). On the other hand, in the transition from the 500 kDa band to the 670 kDa band, a structural rearrangement of the bc 1 complex may occur due to the binding of ISP and ... specifically required for the insertion of ISP into an immature bc 1 complex and that the association of the Qcr9p subunit with the bc 1 complex precedes the bi...
Ngày tải lên: 18/02/2014, 08:20
Báo cáo khoa học: A unique tetrameric structure of deer plasma haptoglobin – an evolutionary advantage in the Hp 2-2 phenotype with homogeneous structure pot
... Schematic drawing of tandem repeat region (B and B1) of deer and human a-chain. The most significant feature of human a2 is that it matches the ABC domains of a1 but with an additional insertion of a redundant ... used in antioxidant therapy [8–10]. Transfection of Hp cDNA into Chinese hamster ovary (CHO) cells protects them against oxi- dative stress [9]. Human Hp is one...
Ngày tải lên: 23/03/2014, 07:20
Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
... is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs and GH13 enzymes, and especially the ... in region I covering the b3-strand; (b) a segment of up to five residues (307_GVDGF in human rBAT) preceding the func- tional arginine (arginine 197 in oligo-1,6-glucos...
Ngày tải lên: 18/02/2014, 13:20
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... whereas HO-2 contains at least two copies of a potential heme-binding site, consisting of the cysteine and proline (CP motif) [7,8]. Importantly, these CP motifs are not involved in heme breakdown ... subjected to northern blot analysis. Each lane contains 15 lg of total RNA. The bottom panel shows the expression of b-actin mRNA as an internal control. (B) Western blot analy...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... results indicate the existence of high and low affinity bindings of mangan- ese ions to arginase II and provide an explanation for the manganese stoichiometries determined here. Con- sidering the ... His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn mutations on the interaction of the e...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
... loop, the first and last turns of helices E and F, and the C-terminus helices I and J. In addition, there is a lysine-rich N- and C-ter- minus, in accordance with the basic isoelectric point of CagS. ... runs anti-parallel to the same strand of a second monomer, allowing for the formation of the dimer. The surface of interaction between monomers also involves portio...
Ngày tải lên: 06/03/2014, 00:21
Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... to the dopamine D 2 receptor and its genetic variants, D 2 R1, D 2 R2, which were localized in the plasma mem- brane and inside the cell. In the case of the dopa- mine D 2 receptor mutants, the ... in uence of an epitope from the third intracellular loop (ic3) of the dopamine D 2 receptor, which contains adjacent arginine residues (217RRRRKR222), and an acidic e...
Ngày tải lên: 07/03/2014, 03:20