Báo cáo khoa học: Full-length adiponectin protects hepatocyt

Báo cáo khoa học: MicroRNA-21 protects neurons from ischemic death pot

... ischemic kidney, and showed that knockdown of Faslg protects renal cells from apoptosis, and, in fact, animals from death. We speculate that overex- pression of miR-21 may represent a way to use an ... used the TUNEL assay to measure the proportion of cells undergoing apoptosis. Inhibition of miR-21 in neurons signiﬁcantly increased the number of TUNEL-positive cells after...

Ngày tải lên : 29/03/2014, 21:20

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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... ischemic and still viable region of the brain called the ‘penumbra’ [14]. Therefore, degree of angiogenesis appears to correlate with rate of recovery from stroke. A variety of angiogenic factors ... biochemically. The afﬁnity of VEGFR-1 for VEGF-A is extremely high (K d = 1–10 pm), 10-fold that of VEGFR-2. However, the tyrosine kinase activity of VEGFR-1 is one order of m...

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine ﬁbrosarcoma L929 cells doc

... anti-apoptotic mechanism of NF-jB have demonstrated that the activation of NF-jB impaired c-Jun N -terminal kinase (JNK) activation [23], or resulted in an increase of Bcl-2 family protein levels ... negative regulator of apoptosis, whereas ERK contributed to apoptosis. Furthermore, ROS might be involved in the activation of ERK pathway in oridonin-induced L929 cells. Inh...

Ngày tải lên : 18/02/2014, 13:20

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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

... STARS stimulates MRTF activity by inducing the dissociation of MRTFs from actin via depletion of the G-actin pool. The N -terminal regions of MRTFs contain three RPEL motifs which have been shown ... C -terminal domain of Pol II [43]. Injection of a peptide acting as a competitive inhibitor of protein–protein contact involving actin and the hnRNP protein, HRP36, into the s...

Ngày tải lên : 07/03/2014, 01:20

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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx

... regulation of eukaryotic PALs Although the regulation of eukaryotic PALs differs, the necessity of rapid inactivation ⁄ decomposition of the enzyme as well as the presence of the C -terminal multi-helix ... three isoenzymes of PAL (PAL1, PAL2 and PAL3) are known [76]. After the ﬁnal chromatofocusing stage of PAL puriﬁcation from suspension-cultured cells of French bean, fou...

Ngày tải lên : 07/03/2014, 12:20

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Báo cáo khoa học: UDP-galactose 4-epimerase from Kluyveromyces fragilis – catalytic sites of the homodimeric enzyme are functional and regulated docx

... inhibition of epimerase offered a sensitive method for deter- mination of stoichiometry of the bound cofactor. Reductive inhibition was applied to 33.3 nmol (5 mg) of epimerase. A control set of the ... basis of binding with the inhibitor. Careful analysis of Fig. 2 shows that inactivation of E 3 by trypsin and reductive inhibition consistently deviated from 50%, in...

Ngày tải lên : 16/03/2014, 00:20

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Báo cáo khoa học: Examining multiprotein signaling complexes from all angles The use of complementary techniques to characterize complex formation at the adapter protein, linker for activation of T cells pdf

... In conﬁrmation of the role of these LAT tyrosines on Ca 2+ inﬂux and the activation of MAP kinases, either mutation of LAT tyrosine 132 or LAT tyrosines 171, J. C. D. Houtman et al. Investigation of multiprotein ... composition of multiprotein complexes are detailed. Also described is the information gained from these techniques and examples of the use of these techniques fo...

Ngày tải lên : 23/03/2014, 15:21

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Báo cáo khoa học: Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer doc

... between NH of Ala88 and CO of Gly72 of human CyPA with a distance of 2.84 A ˚ . T he ﬁxing by hydrogen bonds of Ala88 and Pro90 to CyPA generates the deviation of x angle of  20° from the plane ... b3 strand, but the N atom of Pro2 is 4.02 A ˚ away from the N g2 atom of Arg43. T he N g1 atom of Arg43 i s not within 5.5 A ˚ from the N atom of Pro2. In addition, NH...

Ngày tải lên : 30/03/2014, 15:20

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Tài liệu Báo cáo khoa học: Chromatin under mechanical stress: from single 30 nm ﬁbers to single nucleosomes pdf

... in Prague, First Faculty of Medicine, Institute of Cellular Biology and Pathology, Prague, Czech Republic 3 Department of Cell Biology, Institute of Physiology, Academy of Science, Prague, Czech ... is composed of an octamer of core histones (two each of H2A, H2B, H3 and H4), a linker histone and  166 bp ( 56 nm) of DNA [6]. The histone octamer alone associates with 146 bp...

Ngày tải lên : 14/02/2014, 18:20

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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... tyrosine kinase inhibitor-induced apoptosis via c-Jun NH 2 -terminal kinase and p38 mitogen-activated protein kinase. Abbreviations BH, Bcl-2 homology domain; Bim, Bcl-2 interacting mediator of cell ... IAP, inhibitor of apoptosis protein; JNK, c-Jun NH 2 -terminal kinase; KIP, kinase inhibitor proteins; MEK, MAPK ⁄ ERK kinase; MKK, MAPK kinase; MKP-1, mitogen-act...

Ngày tải lên : 16/02/2014, 09:20

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Báo cáo khoa học: Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-Jun NH2 terminal kinase doc

Báo cáo khoa học: MicroRNA-21 protects neurons from ischemic death pot

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc