Báo cáo khoa học: Enzymatic control of anhydrobiosis-related accumulation of trehalose in the sleeping chironomid, Polypedilum vanderplanki pdf
Báo cáo khoa học: Enzymatic control of anhydrobiosis-related accumulation of trehalose in the sleeping chironomid, Polypedilum vanderplanki pdf
... originating from the glycogen stored in fat body cells.Changes in the activities of trehalose metabolismenzymes in P. vanderplanki during desiccation The activities of the enzymes involved in trehalose metabolism ... in the resultant proteins [21,22]. Furthermore, the effects of overexpression of dtps1 on trehalose levels in rela-tion to anoxia tolerance [21], and the involvement of Har-Tps in diapause induction ... by a kind of side-effect of transformation or the presence of traceamounts of the PvTPSb protein.Thermosensitivity in the tps2D + PvTpp strain wasrescued to almost the same level as the wild-type(Fig....
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Báo cáo khoa học: Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal b-N-acetylhexosaminidase pot
... orientation of the acetyl group during the formation of the oxazo-linium ring. This distance shortened from 4.4 A˚ in the Fig. 7. Docking of N-acetylhexosamine substrates into the active site of the ... the diffusion and access of the substrate to the bind-ing site of the enzyme, as well as the release of the prod-ucts. In conclusion, in this paper we have clarified the chemical nature of the ... site of the enzyme leads to a shift in theirposition, resulting in decreased access of the hydroly-sing groups of the active-site amino acids to the glyco-sidic bond (Fig. 8C). The substrate in...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... leading to the preferential hydration of the protein domain is the driving force of protein stabiliza-tion or folding [3,4]. Furthermore, the effect of osmolytes on the functional activity of ... DGD° values in the presence of these osmolytes are given in Table 1. How-ever, DGD° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethyl-glycine have ... [36,references therein]. The binding model claims that anincrease in the osmolyte-induced stability arises from the preferential hydration (or exclusion of the osmo-lyte) leading to a shift in the denaturation...
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Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt
... with in the treatment of VP-eUipsis, perhaps at the cost of some degree of the- oretical inelegance. However, this aspect was crucial for handling the gapping data, since the infelicity of gapping ... that reinforces one of the meanings. For instance, gapping is felicitous in passage (3), where con- text supports the symmetric reading, but is infelicitous in passage (4) under the intended ... referential forms as to whether they leave behind an empty constituent in the syntax and whether they are anaphoric in the semantics. Empty. constituents in the syntax are not in themselves refer-...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... deletion of Synoviolin causes a change in the intracellular trafficking of NCT.Effect of Synoviolin on the production of AbNCT is one of the essential cofactors of the c-secretasecomplex. We therefore ... SupportingInformation). We also determined the levels of c-secre-tase-unrelated ER protein (calnexin) and cytoskeletonprotein (tubulin) in these cells as the internal control proteins. The calnexin ... generation.Results Accumulation of immature NCT in synoviolin-nullcellsTo investigate whether Synoviolin is involved in the degradation of PS cofactors, we first compared the levels of PS cofactors by...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... explained by the proximity of the mutation to the cleavage site, probably resulting in asmall interference with the binding of the activator to the FXI zymogen.There are some examples of inherited ... activation loop at the N-terminus of the catalyticdomain, are notable. In the zymogen FXI, Ile371 is exposed to the solvent, while in the activated FXI it is inserted into the protein. The picture ... (1993) The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-throm-bin. Biochem J 289, 475–480.45 Baglia FA & Walsh PN (1996) A binding site...
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Báo cáo khoa học: "A Feedback-Augmented Method for Detecting Errors in the Writing of Learners of English" docx
... errors since they are based on the articlesand the distinction between singular and plural.Finally, the tagged instances are stored in a filewith their surrounding words. Each line of it con-sists ... 1(a)?modified by one of the words in Table 1(b)?modified by one of the words in Table 1(c)?Figure 1: Framework of the tagging rulesTable 1: Words used in the tagging rules(a) (b) (c) the indefinite article ... detected in thisstep, the rest of the steps are not applied. In the second step, errors are detected by the rules described in Table 3. The symbol “” in Ta-ble 3 denotes that the combination of the...
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Tài liệu Báo cáo khoa học: "A Multimodal Interface for Access to Content in the Home" pdf
... understanding of system capa-bilities. Of the remaining 66% of inputs (2166) which were within the functionality of the system, 68% were in grammar. On the within functionality portion of the data, ... sets of scenarios and then freely interacting with each system. For counterbalancing purposes, half of the subjects used the tablet and then the re-mote control and the other half used the ... the pen. In the remote control version, the recog-nizer can also be activated using a button on the remote control. The main section of the search display (Figure 2) contains two panels. The...
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Tài liệu Báo cáo khoa học: "A Tool for Multi-Word Expression Extraction in Modern Greek Using Syntactic Parsing" pdf
... languagelearners—by displaying them in the original con-text. The following functions are provided:Filtering and sorting The results which willbe displayed can be selected according to seve-47 ... Currently, thereare approximately 60 grammar rules defined forGreek, allowing for the complete parse of about50% of the sentences in a corpus like Europarl(Koehn, 2005), which contains proceedings of the ... contains proceedings of the European Parliament. For the remaining sen-tences, partial analyses are instead proposed for the chunks identified.One of the key components of the parser is its(manually-built)...
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Báo cáo khoa học: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt
... hinder the entrance of acetylcholine to the CAS in the wild-type enzyme, it appears that, in the two mutants(Trp83Ala ⁄ Glu), inhibitors that bind to the PAS didnot prevent the entrance of ... mutants: the strong decrease of inhibition of propidium [21] and the increase of remaining activity upon peripheral site saturation byfasciculin [24].Finally, minor deviations of pS curves upon binding of ... used the specific equation in Scheme 1. The effect of two ligands on the activity of the wild-type DmAChE was evaluated by the equation in Scheme 1 enlarged by the intermediates, repre-senting the...
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