Báo cáo khoa học: Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model pptx

... 2010 FEBS 3563 Tumor suppressor p16 INK 4a : Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model Hugo Sanchez-Ruderisch 1, *, ... glycogene microarray analysis, chromatographic glycan profiling and lectin binding [9]. In uencing N- and O-glycan galactosylation and sialylation, salie...

Ngày tải lên: 29/03/2014, 21:20

... (JAC) Gal ⁄ GalNAc Galb3GalNAca Arachis hypogaea (peanut) PNA Gal Galb3GalNAca Canavalia ensiformis (jack bean) Con A Man ⁄ Glc GlcNAcb2Mana6(GlcNAcb2Mana3)Manb4GlcNAc Datura stramonium (thorn apple) ... Galb4GlcNAcb6(Galb4GlcNAcb2)Man Galanthus nivalis (snowdrop) GNA Man Mana6(Mana3)ManaR Glycine max (soybean) SBA GalNAc GalNAca3Galb6Glc Griffonia simplicifolia I GSA I GalNAc GalNAca3Gal,...

Ngày tải lên: 16/03/2014, 10:20

... member of the ADAM (a disintegrin and metalloproteinase) family of type I membrane proteins and mediates the ectodomain shedding of various membrane- anchored signaling and adhesion proteins. TACE ... anti-TACE, and a polyclonal rabbit antibody against endogenous TACE (Chemikon International, Temecula, CA). Both antibodies are directed against the C-terminal part of the p...

Ngày tải lên: 08/03/2014, 02:20

... expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA 99, 6047–6052. 48 Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin WG Jr & Liu W (2002) The human ... stimulation of the human lung carcinoma cell line, A5 49, with TNF -a increases the expression of caspase-1 mRNA and pro- tein. The increase in caspase-1 gene expressi...

Ngày tải lên: 16/03/2014, 05:20

... can alternatively activate the IKK complex via interaction of the TAK1 complex, consist- ing of the TAK1 kinase and its associated proteins TAK1-binding protein 1 ⁄ 2⁄ 3 (TAB 1, TAB 2 and TAB ... modification to the animals might have an in uence on many different aspects of TNF signal- ing. Deletion of the TNF might lead to alterations in the balance of intricate si...

Ngày tải lên: 28/03/2014, 23:20

... characterized and the most prominent path- ways are the extrinsic and intrinsic pathways. In the intrinsic pathway (also known as the ‘mitochondrial pathway’), apoptosis results from an intracellular ... effect of HSS against CCCP-induced apoptosis, the activation of caspase-3 was examined using the enzymatic Caspase-Glo 3 ⁄ 7 assay. After CCCP treat- ment, caspase-3 activ...

Ngày tải lên: 16/02/2014, 09:20

... 5¢-GGAGATCTCCAGTGA TATCGACCA-3¢ and 5¢-ACGGCTTCTACGGATCGAA ACT-3¢ for PPARc ,5¢-AAGACAGCTCCTCCTCGAAGG TT-3¢ and 5¢-TGACCAAATCCCCATTTACGC-3¢ for aP2, 5¢-ATCCATGGATGGACGGTAACG-3¢ and 5¢-CTGGA TCCCAATACTTCGACCA-3¢ ... Ækg )1 ; Abbott Laboratories, North Chicago, IL, USA), CT analysis was performed with a micro-CT scanner (LaTheta LCT-100; Aloka, Tokyo, Japan). Data were analyzed using latheta...

Ngày tải lên: 16/02/2014, 09:20

... domains (a b-domain for the N-terminal cluster and an a- domain for the C-terminal cluster). In the absence of metals, apo-thionein (apo-T) is predominantly unstruc- tured and only upon metal ... trans-amminedichloridoplatinum(II) (transplatin) has been studied. These reactions are of interest because MTs play an important role in the acquired Metal–thiolate clusters i...

Ngày tải lên: 16/02/2014, 15:20

... that this limitation is retreating, whereas the importance of accurate modeling and analy- sis approaches aiming at understanding the complex interactions in living cells is increasing. Materials ... and the choice of parameterizing variable x for the ZDP manifolds. The PTS is a mixed signal transduction and transport pathway involved in transporting various sugars into en...

Ngày tải lên: 18/02/2014, 06:20

... binding characteristics and hyper- anticoagulant activity. Binding ability was established using a SPR membrane binding assay and anticoagu- lant activity was assessed by a thrombin generation assay. ... numbered lanes) was applied to each lane and visualized by silver staining. Protein C vari- ants and molecular weight markers (MWM) ran in each lane are indicated. The location of h...

Ngày tải lên: 18/02/2014, 06:20