Báo cáo khoa học: and protein bilinear indices – novel bio-macromolecular descriptors for protein research: I Predicting protein stability effects of a complete set of alanine substitutions in the Arc repressor ppt
Báo cáo khoa học: and protein bilinear indices – novel bio-macromolecular descriptors for protein research: I. Predicting protein stability effects of a complete set of alanine substitutions in the Arc repressor ppt
... order. These
statistical parameters suggest that linear combinations
of protein bilinear indices are appropriate for the dis-
crimination of near wild-type stability ⁄ reduced stability
mutants ... correlation between protein bilinear indi-
ces and stability (t
m
) for these mutants, leading to a non-
linear dependence between t
m
and the protein bilinear...
Báo cáo khoa học: K182G substitution in DevR or C8G mutation in the Dev box impairs protein–DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis doc
... mutational analysis of
protein and DNA (in a half-site of the primary binding
motif), we highlight the singular importance of G
13
–
Lys182 and partial importance of A
12
–Lys182 inter-
action for ... contain
glycine or alanine in place of K182 in the WT protein
wherein the side chain amino group of K182 residue in
each subunit is involved in H...
Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling ppt
... levels and native PKA a ctivity.
On the other hand, HIP/PAP via its interaction with RIIa
might i mpair t he association of P KA catalytic subunits with
the R IIa dimer, th us increasing PKA native ... cytosol. Basal PKA activi ty was in-
creased in HIP/PAP expressing cells, suggesting that
HIP/PAP may alter PKA signalling. Indeed, we showed,
using a thymidine kinase-lucifer...
Tài liệu Báo cáo khoa học: A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells doc
... Bottaro, David Gray,
Alexandra Livingstone and Bert Vogelstein for providing advice and/
or reagents. Julie Richards is a trainee in the Medical Scientist
Training Program funded by NIH grant, T32 ... the ability to use the
same CD40-targeting peptide for murine and human
applications should provide an important advantage in
translation of experimental findings to a c...
Báo cáo khoa học: "A Meta-Level Grammar: Redefining Synchronous TAG for Translation and Paraphrase" doc
... demonstrates that
translation involving clitics causes problems un-
der this definition, as in (3). The partial deriva-
tion trees containing the clitic
lui
and its English
parallel are as in ... an input string if this string
is grammatical. An overview of TAGs is given
in Joshi and Schabes (1996).
The characteristics of TAGs make them better
suited to describing n...
Báo cáo khoa học: "An Error-Driven Word-Character Hybrid Model for Joint Chinese Word Segmentation and POS Tagging" docx
... Model
for Joint Chinese Word Segmentation and POS Tagging
Canasai Kruengkrai
†‡
and Kiyotaka Uchimoto
‡
and Jun’ichi Kazama
‡
Yiou Wang
‡
and Kentaro Torisawa
‡
and Hitoshi Isahara
†‡
†
Graduate ... 619-0289 Japan
{canasai,uchimoto,kazama,wangyiou,torisawa,isahara}@nict.go.jp
Abstract
In this paper, we present a discriminative
word-character hybrid model for joint Chi-
nese...
Báo cáo khoa học: TioS T-TE – a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides potx
... spectrum of
anti-proliferative activity against various cancer cell
lines in vitro that are undergoing preclinical trials
phase II [28,29]. Organic synthesis of the aza- and oxa-
thiocoraline-class ... investi-
gated substrates in graphical form in Fig. S 5A C.
DNA-bisintercalation activity assay
To evaluate the DNA-bisintercalative properties of
chemoenzymatically generated...
Báo cáo khóa học: Volkensin from Adenia volkensii Harms (kilyambiti plant), a type 2 ribosome-inactivating protein pptx
... volkensin A- chain (A) and B-chain (B). The inserts of (A) show the amino acid residues of the active site of volkensin (I) and
ricin (II), respectively. Binding sites 1 and 2 of the volkensin B-chain ... a novel amino
acid residue found to be conserved in all known ribosome-
inactivating proteins. The sugar binding site 1 of the ricin
B-chainisalsoconserved...
Báo cáo khoa học: A human-specific TNF-responsive promoter for Goodpasture antigen-binding protein potx
... transcriptional initi-
ation in TATA-less promoters, a canonical Sp1 binding
site and a TATA-like element [1 3–1 5], and a NFjB-like
binding site for transcriptional regulation (Fig. 3A) .
The contribution ... only in
humans. Goodpasture antigen-binding protein (GPBP)
is a serine ⁄ threonine kinase that specifically targets a
motif in the NC1 domain of the hum...
Tài liệu Báo cáo khoa học: Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations ppt
... complex mass action kinetics, a clear
indication of the important role that it has played in
biochemical modeling. A series of mathematical studies
[1 7–1 9] have quantified its accuracy, proving it to ... 17 5–2 01.
Supporting information
The following supplementary material is available:
Doc. S1. An algorithm for the numerical calculation of
constraining relations bas...
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