Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc

... further analysis. Binding of endogenous Sp1 from lung cancer cell lines to the p73 P1 promoter In order to validate the ability of endogenous Sp1 to bind to the p73 P1 promoter within the cellular environment, ... FEBS 3027 Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73 c in lung c...

Ngày tải lên: 29/03/2014, 09:20

... ligand is involved in the initial homing of leuko- cytes to sites of in ammation [73,74]. The binding of PSGL-1 to P-selectin is largely due to two PTMs, namely an O-glycan that contains tetrasaccharide sialyl-Lewis X , ... in ammation in mammalian brain tissue both in vitro and in vivo, including in the detection of cerebral malaria. Retooling of this repo...

Ngày tải lên: 18/02/2014, 17:20

... using combinations of immunohisto- chemical and in situ hybridization techniques in order to fully understand the extent of the UII system. The involvement of the UII system in sleep also points ... (PPT), and no other expression sites could be found [32]. Further investigation of the receptors’ site of action using in situ binding techniques revealed a muc...

Ngày tải lên: 19/02/2014, 07:20

... further the reactivity of S23906-1 towards the bionucleophiles DNA and GSH. The covalent binding of the drug to GSH reduced the formation of DNA adducts and slightly decreased the cytotoxic potential ... guanine residues at the N2 position in double- stranded DNA [11]. The covalent binding to DNA is apparently responsible for the cytotoxic action [12] and...

Ngày tải lên: 20/02/2014, 11:20

... December 2010) doi:10.1111/j.1742-4658.2010.07986.x The ibuprofen primary binding site FA3–FA4 is located in domain III of human serum albumin (HSA), the secondary clefts FA2 and FA6 being sited in domains I and II. Here, the thermodynamics of ... by ibuprofen binding not only to both secondary sites located in domains I and II, but also to the primary cleft sited...

Ngày tải lên: 06/03/2014, 01:20

... hindrance or over- laps with the ApoE domain involved in the interaction with LCAT. Whether Hpt binding to ApoE also results in protection of the stimulatory domain of this apolipoprotein against ... from o-phenylenediamine as previously described [7]. Nonspecific binding was determined by omitting the Hpt loading in the wells. Inhibition of Hpt binding to Hb-coated w...

Ngày tải lên: 07/03/2014, 00:20

... UMP-CMP kinase binds the phosphodonor, usually ATP, and the NMP at different binding sites. The reaction results from an in- line phosphotransfer from the donor to the acceptor. The probe for the donor site ... the cytosol, but isoforms 2 and 3 of AMP kinases are found in the mitochondria and isoform 6 in the nucleus. Another dTMP kinase, as yet unidentifie...

Ngày tải lên: 07/03/2014, 09:20

... mediator of the action of the bacterial heat-stable enterotoxin peptides (ST) [4–6]. In addition, robust GC-C expression is also observed in the regenerating rat liver [7] and in extraintestinal ... regulation of any receptor-mediated signaling pathway is integral for maintaining normal homeostasis of a cell. Initial activation of a receptor by its ligand results in...

Ngày tải lên: 08/03/2014, 08:20

... chain is brefeldin A-insensitive and is inhibited by the proteasome inhibitor clasto-lactacystin b-lactone, resulting in the accumulation of ricin A chains. These stabilized ricin A chains are partly deglycosylated ... been found in plants, and the underlying mechanism of BAX inhibitor 1 remains unknown. The ERSE-like cis-acting regulatory element is found in the prom...

Ngày tải lên: 16/03/2014, 11:20

... and the TKK decoder (Hirsim ¨ aki et al., 2006). The main structure of the baseline sys- tems for each of the four languages is similar and fairly standard and in line with most other state -of- the- art ... al., 2010). The user can zoom in the world map and select any voice, which are organized according to the place of living of the adapted speaker, t...

Ngày tải lên: 17/03/2014, 00:20