Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
... further analysis.Binding of endogenous Sp1 from lung cancer cell lines to the p73 P1 promoter In order to validate the ability of endogenous Sp1 to bind to the p73 P1 promoter within the cellularenvironment, ... FEBS 3027 Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73 c in lung cancer Stella Logotheti1, Ioannis Michalopoulos2, Maria Sideridou3, Alexandros Daskalos4,Sophia ... cell lines and tumour samples. Sp1 was found to activate the transcription of TAp73c in lung cancer via highly con-served Sp1- binding sites on the p73 P1 promoter. In addition, TAp73c and Sp1...
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Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
... ligand is involved in the initial homing of leuko-cytes to sites of in ammation [73,74]. The binding of PSGL-1 to P-selectin is largely due to two PTMs,namely an O-glycan that contains tetrasaccharidesialyl-LewisX, ... in ammation in mammalian brain tissue both in vitro and in vivo,including in the detection of cerebral malaria.Retooling of this reporter system also allowed sys-tematic investigation of the ... in a matter of hours.As a demonstration of the biological relevance, thismethodology was used to model the P-selectin-bindingdomain of the mucin-like glycoprotein PSGL-1 [73,74].This ligand...
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Tài liệu Báo cáo khoa học: From heart to mind The urotensin II system and its evolving neurophysiological role ppt
... using combinations of immunohisto-chemical and in situ hybridization techniques in order to fully understand the extent of the UII system. The involvement of the UII system in sleep also points ... (PPT), and no other expression sites could befound [32]. Further investigation of the receptors’ site of action using in situ binding techniques revealed amuch broader expression of the receptor. ... ourunderstanding of the molecular constituents of the UIIsystem in mammals seems to be complete, the anatom-ical distribution of the precursors on the protein levelstill remains to be established in...
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Tài liệu Báo cáo khoa học: Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1 doc
... further the reactivity of S23906-1 towards the bionucleophiles DNA and GSH. The covalent binding of the drug to GSH reduced the formation of DNA adducts and slightly decreased the cytotoxic potential ... guanine residues at the N2 position in double-stranded DNA [11]. The covalent binding to DNA isapparently responsible for the cytotoxic action [12] and the capacity of the drug to trigger apoptosis ... under-going phase II clinical trials [24]. The cytotoxic action of thisDNA minor-groove-binding agent is significantly enhanced in the presence of GSH and this effect is believed to originate from the...
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Báo cáo khoa học: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme–albumin doc
... December2010)doi:10.1111/j.1742-4658.2010.07986.x The ibuprofen primary binding site FA3–FA4 is located in domain III of human serum albumin (HSA), the secondary clefts FA2 and FA6 beingsited in domains I and II. Here, the thermodynamics of ... by ibuprofen binding not only to bothsecondary sites located in domains I and II, but also to the primary cleft sited in domain III [20].lValues of K2 and K3for ibuprofen binding to tHSA–heme-Fe(III) ... occurring at the heme-bindingpocket (FA1). Indeed, ibuprofen binding to HSA–hemehas been reported to induce the hexa-coordination of the heme Fe atom [18,21,23]. Thus, peroxynitrite can-not bind...
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Báo cáo khoa học: Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes pdf
... hindrance or over-laps with the ApoE domain involved in the interactionwith LCAT. Whether Hpt binding to ApoE alsoresults in protection of the stimulatory domain of thisapolipoprotein against ... fromo-phenylenediamine as previously described [7]. Nonspecificbinding was determined by omitting the Hpt loading in the wells.Inhibition of Hpt binding to Hb-coated wells, in the pres-ence of ApoA-I ... might impair the hepatocytes’ ability to recognize ApoE-containing and ApoA-I-containinglipoproteins, and therefore could unbalance the con-centration of circulating lipoproteins. The link betweenlipoprotein...
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Báo cáo khoa học: Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives ) a screening based on affinity for the UMP-CMP binding site potx
... UMP-CMP kinase binds the phosphodonor, usually ATP, and the NMP at different binding sites. The reaction results from an in- linephosphotransfer from the donor to the acceptor. The probe for the donorsite ... the cytosol, but isoforms 2 and 3 of AMP kinases are found in the mitochondria and isoform 6 in the nucleus. Another dTMP kinase, asyet unidentified, may be located in mitochondria [8]. The primary ... fluorescence of MABA-CDP to its initial value, demonstrating the specificity of MABA-CDP binding to the acceptor-binding site (Fig. 3A, inset). Titration of MABA-CDPwith the enzyme (Fig. 3A) indicated...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... mediator of the action of the bacterial heat-stable enterotoxin peptides (ST) [4–6]. In addition, robust GC-C expression is also observed in the regenerating rat liver [7] and in extraintestinal ... regulation of any receptor-mediated signaling pathwayis integral for maintaining normal homeostasis of a cell.Initial activation of a receptor by its ligand results in the triggering of a cellular ... byenterotoxigenic Escherichia coli are one of the major causes of transitory diarrhea in the developing world. Toxin bind-ing to its receptor, guanylyl cyclase C (GC-C), results in receptor activation...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... chain is brefeldin A-insensitive and isinhibited by the proteasome inhibitor clasto-lactacystinb-lactone, resulting in the accumulation of ricinA chains. These stabilized ricin A chains are partlydeglycosylated ... beenfound in plants, and the underlying mechanism of BAX inhibitor 1 remains unknown. The ERSE-likecis-acting regulatory element is found in the promoter region of Arabidopsis BAX inhibitor 1 gene ... underlying the UPR between organisms. In yeast, the UPR increases the folding and degrada-tion capacities of unfolded proteins by inducing the expression of genes related to those capacities [1]. Inos-itol-requiring...
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Báo cáo khoa học: "Personalising speech-to-speech translation in the EMIME project" pptx
... and the TKK decoder (Hirsim¨aki et al.,2006). The main structure of the baseline sys-tems for each of the four languages is similar and fairly standard and in line with most other state -of- the- art ... al., 2010). The usercan zoom in the world map and select anyvoice, which are organized according to the place of living of the adapted speaker, to ut-ter the given sentence. This interactive ... pre-being a convenient interface to compare the many voices, the interactive map is an attrac-tive and easy -to- understand demonstration of the technology being developed in EMIME.3. The models...
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