Báo cáo khoa học: Mucin-type O-glycosylation – putting the pieces together docx

Báo cáo khoa học: "Medical treatment for the terminally ill: the ‘risk of unacceptable badness’"

... that they can make any decisionthey want as an open-ended ideal. This puts them in the position of being buyers in a consumer’s market. Byasking them to make a choice, they imply that theirauthority ... life-in-death[4]. Patients may be stalled in suspended animation; they arenot alive in the sense the we enjoy life but neither are theyable to die as long as nutrition, hydration, ventilation, ... in the death of a loved one. Once life-supporting care is instituted, the patient has options for‘survival’ that they did not have before, even though theyare dependent on ‘life support’. There...

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... (2011) 101 0–1 019 ª 2011 The Authors Journal compilation ª 2011 FEBSwhether this loop aims only at activating the male path-way, or repressing the female one, or both.In zebraﬁsh, the transcription ... genetic studies led to the view that, across the animal kingdom, the gene-regulatory cascades triggering sexual develop-ment bear little resemblance to each other. As a result, the common emerg-ing ... emerg-ing picture is that the genes at the top of the cascade are not conserved,whereas the downstream genes have homologues in a much broader spec-trum of species. Among these downstream effectors,...

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... ligands. The additional water occupied the postulated superoxide bind-ing site. The thermal stability of the enzyme was compared with superoxidedismutase from Thermus thermophilus, a thermophilic ... ApeSODs. (A–C) The orange maprepresents the rA-weighted Fo)Fcelectron density map at the 3 r level, where the indicated residues are excluded from the calculation of the structure factor. The ... additional water oxy-gen, which, together with the OD2 of Asp165, the NE2 of His79 and the NE2 of His169, formed anequatorial plane (Fig. 3B). The metal ion and the addi-tional water oxygen were...

Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

... to the catalytic site of the R1E subunit. Asreported in the Results, upon completion of substrateconversion, the radical is then rapidly passed backfrom the R1E subunit to the tyrosyl of the ... other class 1RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E.We consider the ﬁrst option unlikely. Under these cir-cumstances, the ... transfer from the tyrosyl rad-ical (Y122) of the R2 subunit to the cysteine (C439)found in the active site of the R1 subunit; (b) the abstraction of two protons and water release, with the concomitant...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... in apoptosis, the relationship of these two molecules is stilllargely unknown. The aim of the current study was to investigate the potential involvement of nucleolin ⁄ C23 in the antiapoptotic ... accompanied by the appear-ance and an increase in the 80 kDa fragment (Fig. 2).Although both the untransfected cells and the cellstransfected with the vector alone started to show the 80 kDa fragment ... suppressed by the antisense oligonucleotide, the protection ofHsp70 is lost.Taken together, our results demonstrate an impor-tant relationship among the regulation of nucleo-lin ⁄ C23, the activation...

Tài liệu Báo cáo khoa học : Các phương thức thể hiện lời nói trên đài phát thanh docx

... ed 3 phuang thdc the bien tren sdng: dpe, dpe kit hpp vdi noi va noi (dng khiu). LDgc Ekyc- theo td didn tieng Viet, li phit thinh lii nhung dieu di dupe viii ra, theo dung trinh ... trong vdn ban quy djnh each dgc cua nha bdo. Ngudi dgc khdng the tuy tien ngdt cdu, ngat doan, ngtmg nghi theo y thich, ma phai men theo dau chdm, ddu phay, cdch su dung ngd doan eua tdc gia ... khdng the yen tam dya hoan toan vao cdc van ban viet sdn, ma da ed phuang thdc "kbdu ngu boa", bdt dau xuat hien nhting dng bien ngdn ngu linh hoat ban. Vi du, ngucd ndi ed the them...

Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

... 3′UTRpri-23apcDNA3miR-23a ASOASO-NC+ – – – – – – + – – – – – ++ – – – – + – + – – – + – – + – – + – – – +2833 2843 3123 3133Fig. 3. IL6R is a direct target of miR-23a. (A) The IL6R 3¢ UTR carries three ... 277 (2010) 372 6–3 734 ª 2010 The Authors Journal compilation ª 2010 FEBS 3727base pairing with the 3¢ UTR of target genes. Further-more, the 2–8 nucleotides of miRNA, known as the ‘seed region’, ... containing the mutations of the miR-23a binding site (Fig. 4A). It was shown thatmiR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP ﬂuorescence in the vector bearing the mutant of the...

Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf

... and the E chainfrom TtAKb-free, and red indicates the distance between the B chain from TtAKb-Thr and the F chain from TtAKb-free. The regions shownin A–E are: A, 4 2–4 5; B, 4 6–5 0; C, 5 1–5 8; ... 3125seen on the map. The electron densities of the sections(residues 5 4–5 6 in chains A and D, residues 5 3–5 9 inchain B, residues 5 5–5 6 in chain C, residues 5 6–5 7 inchain E, and residues 5 3–5 6 in ... displays the Ca models of the B chain (residues 1 5–9 3) from TtAKb-Thr and the F chain (residues 1 5–9 3)from TtAKb-free, and ACT2 shows Ca models of the A chain (residues 5–1 4 and 9 4–1 57) from...

Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression proﬁling ppt

... consequently, the 20E-dependent activation is blocked. The presence of 20E,however, favors the formation of the AaEcR⁄ AaUSPheterodimer [13], indicating that the regulation of the activity of these ... al.1248 FEBS Journal 276 (2009) 123 3–1 254 ª 2009 The Authors Journal compilation ª 2009 FEBStheir putative functions. Taken together, these datasupport our hypothesis that our observed ampliﬁcationof ... aegypti, the discrete expressionof both AaHR3 and AaHR4 suggests their function in the regulatory hierarchy in the mosquito fat body dur-ing vitellogenesis. Indeed, the analysis of the upstreamregion...

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

... transition for cJun–FosW can beestimated based on the meqvalue ()6.8) taken from the cJun(R)–FosW(E) mutant (Table 1, Fig. 5). On the basis of these data, it appears that the parent cJun–FosW molecule ... increased ‘residencytime’ for the protein–antagonist complex. It has beenspeculated that the longer the antagonist–target inter-action prevails, the higher the efﬁcacy of the antago-nist is likely ... track the design of peptides with the potential to serve as leads for the design and synthesisof therapeutic mimetics.Materials and methodsPeptide synthesis and puriﬁcationPeptides were synthesized...

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