Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt

... Division of Cancer Sciences, Faculty of Medicine, University of Glasgow, UK Introduction Death-associated protein kinase (DAPK) is a cal- cium ⁄ calmodulin-regulated serine ⁄ threonine protein kinase, ... MINIREVIEW Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer Alison M. Michie, Alison M. McCaig, Rinako Nakagawa and...

Ngày tải lên: 29/03/2014, 08:20

... 2009) doi:10.1111/j.1742-4658.2009.07412.x Death-associated protein kinase (DAPK) regulates many distinct signalling events, including apoptosis, autophagy and membrane blebbing. The role of DAPK in the blebbing process is only beginning ... tropomyosin and the actin-bundling protein, a-actinin. Finally, myosin is recruited and is concentrated in a few distinct dots along...

Ngày tải lên: 29/03/2014, 08:20

... 2007) doi:10.1111/j.1742-4658.2007.05799.x Globins are the most common type of oxygen-binding protein in annelids. In this paper, we show that circulating intracellular globin (Alvinella pom- pejana and Glycera dibranchiata), noncirculating ... DHP, extracellular and intracellular globins (circula- ting and noncirculating) amino-acid sequences. Intracellular globin sequences are s...

Ngày tải lên: 19/02/2014, 02:20

Ngày tải lên: 29/03/2014, 08:20

... novel protein protein interaction motifs, and how these new protein protein interactions give insight into DAPK functions in diverse cellular processes, including growth factor signalling, the regulation ... September 2009) doi:10.1111/j.1742-4658.2009.07411.x Death-associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes...

Ngày tải lên: 29/03/2014, 08:20

... death-associated protein kinase (DAPK) in the regulation of autophagy is particularly interesting. DAPK is a serine ⁄ threonine kinase originally isolated by a genetic screening for positive mediators of interferon-c-induced ... responding to growth factors and amino acid signaling, (b) AMP-activated protein kinase, which activates autophagy through the inhibi- tion of mT...

Ngày tải lên: 29/03/2014, 08:20

... insulin are phosphatidylinositide-3 -kinase (PI-3K), phosphotidylino- sitide dependent kinase- 1 (PDK-1) and protein kinase B (PKB, also called Akt) [3,4]. When insulin receptor binds to insulin, ... activated by insulin via IRS-1). ILK combines with an adaptor protein Nck2 and a five LIM domain- containing protein named PINCH (a particularly interesting new cysteine histidine p...

Ngày tải lên: 21/02/2014, 00:20

... pro- teins Rac1 and Cdc42 to the c-Jun N-terminal kinase/ stress-acti- vated protein kinase pathway. A role for mixed lineage kinase 3 /protein- tyrosine kinase 1, a novel member of the mixed lineage kinase ... MAPKKK, MAPKK kinase; MUK, MAPK-upstream kinase; DLK, dual leucine zipper-bearing kinase; IjB, inhibitor of NF-jB; MBIP1, MUK-binding inhibitory protein 1; IKK, IjB...

Ngày tải lên: 17/03/2014, 09:20

... be obtained by fusing the protein of interest to the N-terminus of an intein, proteins with N-terminal Cys by fusing to the C-terminus of a mutated intein. Separation occurs by using the Chitin binding ... of proteins with C-terminal thioester or N-terminal Cys Inteins and their use in protein chemistry Inteins are internal segments of precursor proteins that catalyze their ipso excis...

Ngày tải lên: 07/03/2014, 15:20

... factor in b-catenin signal- ing. In other words, LPS inactivates GSK3b through phosphorylation, and the inactivated GSK3b inhibits the degradation of b-catenin, promoting translocation into the ... including NoxO1, NoxA1 and Rac1 [5]. The most well-studied activation of Nox1 is that of angiotensin II mediating phospholi- pase C and protein kinase C in vascular smooth mus- cl...

Ngày tải lên: 22/03/2014, 21:21