Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis doc

... MINIREVIEW Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis Chanhee Kang and Leon Avery Department of Molecular ... age-dependent damaged proteins and organelles and thus promote lifespan extension. Fig. 3. Schematic diagram of autophagy signaling pathway in C. elegans....

Ngày tải lên: 29/03/2014, 08:20

... factor in b-catenin signal- ing. In other words, LPS inactivates GSK3b through phosphorylation, and the inactivated GSK3b inhibits the degradation of b-catenin, promoting translocation into the ... NoxO1, NoxA1 and Rac1 [5]. The most well-studied activation of Nox1 is that of angiotensin II mediating phospholi- pase C and protein kinase C in vascular smooth mus- cle ce...

Ngày tải lên: 22/03/2014, 21:21

Ngày tải lên: 29/03/2014, 08:20

... September 2009) doi:10.1111/j.1742-4658.2009.07411.x Death-associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal- induced cell death and autophagy. Although the kinase domain of ... of peptide apta- mers to define novel protein protein interaction motifs, and how these new protein protein inter...

Ngày tải lên: 29/03/2014, 08:20

... 2009) doi:10.1111/j.1742-4658.2009.07412.x Death-associated protein kinase (DAPK) regulates many distinct signalling events, including apoptosis, autophagy and membrane blebbing. The role of DAPK in the blebbing process is only beginning ... recruitment of tropomyosin and the actin-bundling protein, a-actinin. Finally, myosin is recruited and is concentrated in a fe...

Ngày tải lên: 29/03/2014, 08:20

... Division of Cancer Sciences, Faculty of Medicine, University of Glasgow, UK Introduction Death-associated protein kinase (DAPK) is a cal- cium ⁄ calmodulin-regulated serine ⁄ threonine protein kinase, ... Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis. FEBS J 276,...

Ngày tải lên: 29/03/2014, 08:20

... receptor binding protein 2-son of sevenless protein/ Ras/Raf/mitogen activated protein kinase kinase/mitogen activated protein kinase pathway [13]. Another function of the PKB signalling pathway is ... The signalling pathway of insulin is similar to that of some other growth factors [2], and the key signalling molecules of insulin are phosphatidylinositide-3 -kinase (P...

Ngày tải lên: 21/02/2014, 00:20

... pro- teins Rac1 and Cdc42 to the c-Jun N-terminal kinase/ stress-acti- vated protein kinase pathway. A role for mixed lineage kinase 3 /protein- tyrosine kinase 1, a novel member of the mixed lineage kinase ... MAPKKK, MAPKK kinase; MUK, MAPK-upstream kinase; DLK, dual leucine zipper-bearing kinase; IjB, inhibitor of NF-jB; MBIP1, MUK-binding inhibitory protein 1; IKK,...

Ngày tải lên: 17/03/2014, 09:20

... pigmentosum A (XPA) protein and solution structure of the XPA minimal DNA-binding domain (XPA–MBD) (PDB entry: 1XPA). 3D structures of each domain in the human replication protein A (RPA) protein are shown. ... characteristic of proteins with nuclease activity, and (b) a C-terminal (HhH) 2 domain (Fig. 5). The C-terminal (HhH) 2 domains of both XPF and ERCC1 mediate bind...

Ngày tải lên: 07/03/2014, 12:20

... be obtained by fusing the protein of interest to the N-terminus of an intein, proteins with N-terminal Cys by fusing to the C-terminus of a mutated intein. Separation occurs by using the Chitin binding ... discussed below. Recombinant generation of proteins with C-terminal thioester or N-terminal Cys Inteins and their use in protein chemistry Inteins are internal segments of...

Ngày tải lên: 07/03/2014, 15:20