Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death docx

... 2009) doi:10.1111/j.1742-4658.2009.07412.x Death- associated protein kinase (DAPK) regulates many distinct signalling events, including apoptosis, autophagy and membrane blebbing. The role of DAPK in the blebbing process is only beginning ... filamin-deficient blebbing cells has not been exam- ined in blebs of cells undergoing cell death. Although the proteins involved...

Ngày tải lên: 29/03/2014, 08:20

... September 2009) doi:10.1111/j.1742-4658.2009.07411.x Death- associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal- induced cell death and autophagy. Although the kinase domain ... participate in cell death in response to various cytokine signals, including IFN-c- induced cell death [2], TN...

Ngày tải lên: 29/03/2014, 08:20

... G (2009) Death- associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death. FEBS J 276, doi:10.1111/j.1742-4658.2009.07412.x. 18 Kang C & Avery L (2009) Death- associated ... Sciences, Faculty of Medicine, University of Glasgow, UK Introduction Death- associated protein kinase (DAPK) is a cal- cium ⁄ calmodulin-regu...

Ngày tải lên: 29/03/2014, 08:20

Ngày tải lên: 29/03/2014, 08:20

... death- associated protein kinase (DAPK) in the regulation of autophagy is particularly interesting. DAPK is a serine ⁄ threonine kinase originally isolated by a genetic screening for positive mediators of interferon-c-induced ... responding to growth factors and amino acid signaling, (b) AMP-activated protein kinase, which activates autophagy through the inhibi- tion of mT...

Ngày tải lên: 29/03/2014, 08:20

... as integrin-linked kinase (ILK, which is also activated by insulin via IRS-1). ILK combines with an adaptor protein Nck2 and a five LIM domain- containing protein named PINCH (a particularly interesting new ... the receptors of insulin and other growth factors. All of these transmembrane receptors contain protein tyrosine kinase activity in their intracellular domain [1]. The s...

Ngày tải lên: 21/02/2014, 00:20

... pro- teins Rac1 and Cdc42 to the c-Jun N-terminal kinase/ stress-acti- vated protein kinase pathway. A role for mixed lineage kinase 3 /protein- tyrosine kinase 1, a novel member of the mixed lineage kinase ... MAPKKK, MAPKK kinase; MUK, MAPK-upstream kinase; DLK, dual leucine zipper-bearing kinase; IjB, inhibitor of NF-jB; MBIP1, MUK-binding inhibitory protein 1; IKK, IjB...

Ngày tải lên: 17/03/2014, 09:20

... be obtained by fusing the protein of interest to the N-terminus of an intein, proteins with N-terminal Cys by fusing to the C-terminus of a mutated intein. Separation occurs by using the Chitin binding ... of proteins with C-terminal thioester or N-terminal Cys Inteins and their use in protein chemistry Inteins are internal segments of precursor proteins that catalyze their ipso excis...

Ngày tải lên: 07/03/2014, 15:20

... factor in b-catenin signal- ing. In other words, LPS inactivates GSK3b through phosphorylation, and the inactivated GSK3b inhibits the degradation of b-catenin, promoting translocation into the ... determined by RT-PCR and was normalized to b-actin. (B) Raw264.7 cells were cultured in 96-well plates in a CO 2 incubator for 1 h. The cells were changed to NaCl ⁄ P i containing luc...

Ngày tải lên: 22/03/2014, 21:21

... expressed proteins were designated with abbreviations indicating their T -protein origin and inclu- sive residues. The specific activities of both CM and PDH were determined for all engineered T -protein ... T -protein for 22 h. Lane 1, ladder; lane 2, T -protein control; lane 3, T -protein after cross-linking. Table 4. HPLC retention times and molecular masses of T -protein fragme...

Ngày tải lên: 31/03/2014, 07:20