Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx

... MINIREVIEW ERK and cell death: ERK1 ⁄ 2 in neuronal death Srinivasa Subramaniam 1 and Klaus Unsicker 2 1 Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, ... whether ERK5 is also involved in ERK1 ⁄ 2-implicated cell death paradigms. ERK1 ⁄ 2 in cellular models of neuronal death The first evidence for a role of ER...

Ngày tải lên: 29/03/2014, 08:20

... frugiperda cell line, Sf9, was maintained and transfected as described previously [19]. To study the role of USP in activation of the reporter promoter in ligand-treated cells, dUSP cDNA in pIE1-4 and ... by way of binding of JH III or closely related structures to the ligand binding pocket of USP [18]. This binding of JH III by USP induces change in USP tertiary conformation [1...

Ngày tải lên: 23/03/2014, 13:20

... subtle and did not appear from comparative studies of natural hLF and rhLF cDNA by in vitro and in vivo antigenicity, iron- binding and release and binding to several ligands [21]. The only indication ... found in secretions such as milk, tears and saliva, but also in the secondary granules of neutrophils (reviewed in [2]). LF is involved in nonspecific host defence aga...

Ngày tải lên: 30/03/2014, 13:20

... MA (2009) ERK and cell death: ERK location and T cell selection. FEBS J. 8 Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation and cell death. FEBS ... 5 Table 1. Continued. In vivo ⁄ cellular model Stimuli inducing cell death Duration of ERK activation promoting cell death Characteristics of cell death...

Ngày tải lên: 29/03/2014, 08:20

... MINIREVIEW ERK and cell death: ERK location and T cell selection Emma Teixeiro and Mark A. Daniels Department of Molecular Microbiology and Immunology, Center for Cellular and Molecular ... signaling is important for determining cell fate decisions in a diverse number of organisms and cell types (reviewed in [7,8]). In thymocytes, c-JunNH 2 -terminal kinase (J...

Ngày tải lên: 29/03/2014, 08:20

... MINIREVIEW ERK and cell death: cadmium toxicity, sustained ERK activation and cell death Patrick Martin and Philippe Pognonec CNRS FRE3094, Universite ´ de ... cadmium-induced ERK activation diminishes cell death, whereas MKP3 exogenous expression diminishes cell death following cadmium intoxication (P. Martin and P. Pognonec, unpublished data). This sustained .....

Ngày tải lên: 29/03/2014, 08:20

... on ADF cell viability, indicating that the reduction in cell viability induced by ANT1 siRNA requires protein synthesis. ANT1-silencing induces ADF cell apoptosis and a non-apoptotic cell death ... to paraptosis To gain more insight regarding the observed reduction in cell viability, we evaluated the mitotic and apoptotic indexes in ANT1 siRNA- and Scramble-transfected...

Ngày tải lên: 29/03/2014, 09:20

... that cells expressing wild-type HFE displayed a striking decrease in cell- surface bind- ing of transferrin, and that little or no reduction in transferrin binding was observed in cells expressing ... transferrin binding Previous reports have established that in certain cell types HFE acts to regulate intracellular iron levels by decreasing the binding of transferrin to transferr...

Ngày tải lên: 06/03/2014, 22:21

... has been reported in a number of cell types, including skin cells. The major HSPs expressed in the skin [5] are Hsp70 (both cognate and inducible forms) [6] and Hsp27 (expressed in a constitutive ... expression and induce DNA damage in a fibroblastic cell line and human fibroblast primary cells, respectively [58,59]. In our study, the effects of GSM-900 exposure on human s...

Ngày tải lên: 07/03/2014, 11:20

... proteins. The selective labeling of proteins by cell- free expression is highly efficient and advantageous compared with the in vivo labeling. No auxotrophic strains and minimal media are needed, and ... modifications and in each case we obtained a high level production in our cell- free system (Fig. 2). In contrast, the conventional in vivo expression Fig. 1. Protein produc...

Ngày tải lên: 30/03/2014, 13:20