Báo cáo khoa học: Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins potx

... Authors Journal compilation ª 2011 FEBS Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins Shengnan Wu, Feifan Zhou, ... dynamics and causes mitochondrial fragmentation that impacts on mitochondrial function and cell function. It is likely that HF-LPLI affects mitochondrial...

Ngày tải lên: 29/03/2014, 00:20

... defense of yeast with mitochondrial dysfunction. cTPxI influences the expression of genes involved in yeast oxidative stress response: mitochondrial function contribution cTPxI participates of H 2 O 2 -mediated ... with H 2 O 2 and (b) the capacity of cTPxI to interfere with the expression of various Yap1-target genes. Results Effects of gene deletion and mitochondrial pe...

Ngày tải lên: 16/03/2014, 14:20

... part of a more general oxidative stress response mechanism, a less hydrophilic oxidant, tBOOH, was considered. This substance is largely used A B C Fig. 3. Effect of H 2 O 2 -induced oxidative stress ... indicated concentrations of H 2 O 2 . C V. Popa et al. Oxidative stress and Ca 2+ FEBS Journal 277 (2010) 4027–4038 ª 2010 The Authors Journal compilation ª 2010 FEBS 4031 t...

Ngày tải lên: 15/03/2014, 23:20

... of ATP as compared to fatty acids. Also, fatty acid-mediated uncoupling of mitochondrial oxidative phosphoryla- tion may result in diminished mitochondrial ATP pro- duction for a given rate of ... Heart Research Institute, Faculty of Health Sciences, University of Cape Town, South Africa 3 Department of Internal Medicine, Division of Cardiology, University of Texas, Hous...

Ngày tải lên: 18/02/2014, 16:20

... decreasing its rate of turnover. We also addressed the fate of several mitochondrial Fe–S proteins in cardiac tissue of MCK mutants, and showed an overall clearance in protein levels of key mitochondrial ... detect carbonylated proteins in the mitochondrial protein fractions. In mitochondria of control mice, appreciable amounts of oxidized proteins were detected, proba...

Ngày tải lên: 23/03/2014, 06:20

... maturation of Fe–S proteins outside of the mitochondria [23]. Additionally, HSS has been shown to induce mitochondrial gene expression and enhance the oxidative phosphorylation capacity of liver ... ability of HSS on cells through mitochondrial permeability (MP). After administration of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a specific agent that leads to depolariza...

Ngày tải lên: 16/02/2014, 09:20

... degradation of Gap1 permease and stress- induced abnormal proteins. Proc Natl Acad Sci USA 100, 11505–11510. 8 Haitani Y, Shimoi H & Takagi H (2006) Rsp5 regulates expression of stress proteins via ... ubiquitination of the substrate proteins. These observations suggest that stress- induced unfolding or mis-folding of proteins may also be a signal for ubiqui- tination...

Ngày tải lên: 18/02/2014, 11:20

... and absence of EDTA (Fig. 1). The rate of oxidation was increased in the presence of the LPSs of both the smooth and rough E. coli, but the rate of oxidation in the presence of the LPS of smooth ... phase of the reaction, but decreased the rate of the slow phase of oxidation in the presence of EDTA. A comparison of rough and smooth LPSs of E. coli and S. minnesota in...

Ngày tải lên: 08/03/2014, 10:20

... Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan 2 Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan 3 Division of Development ... aggregation of causative proteins is a hallmark of all polyglutamine diseases and of some polyalanine diseases. Moreover, Huntington’s disease-like 2, of which th...

Ngày tải lên: 23/03/2014, 07:20

... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. 55 Laemmli UK (1970) Cleavage of structural proteins during the assembly of the ... cofactor homeostasis and the function of mitochondrial FAD-binding enzymes. Correlation of these has been demonstrated in human pathologies, including deficiencies of the...

Ngày tải lên: 23/03/2014, 07:20