Báo cáo khoa học: Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial ﬁssion–fusion proteins potx

... Authors Journal compilation ª 2011 FEBS Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial ﬁssion–fusion proteins Shengnan Wu, Feifan Zhou, ... dynamicsand causes mitochondrial fragmentation that impactson mitochondrial function and cell function. It is likelythat HF-LPLI affects mitochondrial dynamics throughthe differential modulation of mitochondrial ... concludethat mitochondrial oxidative stress mediated through Drp1 and Mfn2 causes an imbalance in mitochondrial ﬁssion–fusion, resulting in mito-chondrial fragmentation, which contributes to mitochondrial...

Báo cáo khoa học: Yeast oxidative stress response Inﬂuences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state pot

... defense of yeast with mitochondrial dysfunction.cTPxI inﬂuences the expression of genes involvedin yeast oxidative stress response: mitochondrial function contributioncTPxI participates of H2O2-mediated ... withH2O2and (b) the capacity of cTPxI to interfere withthe expression of various Yap1-target genes.ResultsEffects of gene deletion and mitochondrial perturbation on the oxidative stress responseWe ... widely used as indica-tors of oxidative stress [41–43]. To determine whetherTSA1 deletion and the mitochondrial dysfunction cangenerate stressful conditions, the levels of sulfhydrylgroups in...

Báo cáo khoa học: Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae potx

... part of a more general oxidative stress response mechanism, a less hydrophilic oxidant,tBOOH, was considered. This substance is largely usedABCFig. 3. Effect of H2O2-induced oxidative stress ... indicatedconcentrations of H2O2.C V. Popa et al. Oxidative stress and Ca2+FEBS Journal 277 (2010) 4027–4038 ª 2010 The Authors Journal compilation ª 2010 FEBS 4031to mimic the oxidative stress that causes ... post-tran-scriptional level, the function of Vcx1p [11,15,16] andinduces the expression of PMC1 and PMR1 genes via activation of the Crz1 transcription factor [15,16]. Therelease of Ca2+from intracellular...

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... of ATPas compared to fatty acids. Also, fatty acid-mediateduncoupling of mitochondrial oxidative phosphoryla-tion may result in diminished mitochondrial ATP pro-duction for a given rate of ... Heart Research Institute, Faculty of Health Sciences, University of Cape Town, South Africa3 Department of Internal Medicine, Division of Cardiology, University of Texas, Houston Medical School, ... heartparallels enhanced mitochondrial respiratory function inresponse to oxidative stress M. Faadiel Essop1,2, W. Y. A. Chan2and Heinrich Taegtmeyer31 Department of Physiological Sciences,...

Báo cáo khoa học: Frataxin deﬁciency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe–S proteins pot

... decreasing itsrate of turnover. We also addressed the fate of several mitochondrial Fe–S proteins in cardiac tissue of MCK mutants, and showed an overall clearance inprotein levels of key mitochondrial ... detectcarbonylated proteins in the mitochondrial proteinfractions. In mitochondria of control mice, appreciableamounts of oxidized proteins were detected, probablydue to the oxidative metabolism of mitochondriaunder ... protein expression of bothATP2, the b-subunit of mitochondrial ATP synthase,and of mitochondrial prohibitin, neither of which con-tains Fe–S clusters or is related to Fe–S proteins, wasunaffected...

Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf

... maturation of Fe–S proteins outside of the mitochondria [23]. Additionally,HSS has been shown to induce mitochondrial geneexpression and enhance the oxidative phosphorylationcapacity of liver ... ability of HSS oncells through mitochondrial permeability (MP). After administration of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a speciﬁc agent thatleads to depolarization of the mitochondrial ... cyclosporin A, an inhibi-tor of MPT. Therefore, we propose that the protective effect of HSS maybe associated with blockade of MPT.AbbreviationsALR, augmenter of liver regeneration; CCCP,...

Tài liệu Báo cáo khoa học: The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide-associated complex Egd2 under stress conditions docx

... degradation of Gap1 permeaseand stress- induced abnormal proteins. Proc Natl AcadSci USA 100, 11505–11510.8 Haitani Y, Shimoi H & Takagi H (2006) Rsp5 regulatesexpression of stress proteins via ... ubiquitination of the substrate proteins. Theseobservations suggest that stress- induced unfolding ormis-folding of proteins may also be a signal for ubiqui-tination of denatured proteins that ... ubiquiti-nation of denatured proteins under stress conditions[32–34]. In addition, identiﬁcation of ubiquitinatedforms of mis-folded proteins by HECT-type ubiquitinligase under stress conditions...

Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt

... andabsence of EDTA (Fig. 1). The rate of oxidation wasincreased in the presence of the LPSs of both the smoothand rough E. coli, but the rate of oxidation in the presence of the LPS of smooth ... phase of thereaction, but decreased the rate of the slow phase of oxidation in the presence of EDTA.A comparison of rough and smooth LPSs of E. coli andS. minnesota in the presence of EDTA ... contribution of the polysaccharide component of LPS to its effect on the oxidation of cross-linked Hb wasthen investigated by a comparison of the effects of roughandsmoothLPSsofE. coli, both...

Báo cáo khoa học: Endoplasmic reticulum stress caused by aggregate-prone proteins containing homopolymeric amino acids doc

... Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan2 Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan3 Division of Development ... aggregation of causative proteins is a hallmark of all polyglutaminediseases and of some polyalanine diseases. Moreover,Huntington’s disease-like 2, of which the symptomsare similar to those of Huntington’s ... inhibition of the UPS by the aggregate of disease-causative proteins may lead to secondary neuronaldamage.Endoplasmic reticulum (ER) stress has been attrib-uted to the pathology of neurodegenerative...

Báo cáo khoa học: Succinate dehydrogenase ﬂavoprotein subunit expression in Saccharomyces cerevisiae – involvement of the mitochondrial FAD transporter, Flx1p ppt

... quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.55 Laemmli UK (1970) Cleavage of structural proteins during the assembly of the ... cofactor homeostasis and the function of mitochondrial FAD-binding enzymes. Correlation of these has been demonstrated in human pathologies,including deﬁciencies of the ﬂavoprotein subunit of respiratory ... Pfanner N &Meisinger C (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell 17, 1436–1450.37 Langer T &...

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