... of reviewers each performed the quality assessment independently. In the case of the RCTs, a third reviewer reconciled the results of the first two reviewers; for the other study designs, the ... terms of the strength of the study designs, we considered RCTs best, followed by non-randomized controlled trials and observational studies. We assessed the quality and consistency of the best ... FDA indication for the treatment of patients with sickle cell disease, as well as the development of the National Heart, Lung, and Blood Institute recommendations for the use of the drug in...