Báo cáo khoa học: Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains pot

... FEBS 1097 Factor- inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains Ming Yang 1 , Rasheduzzaman Chowdhury 1 , ... FIH-catalysed Asn hydroxylation sites (Fig . 1A) [8]. The positioning of these His residues within the hydroxylation consen- sus, coupled with...

Ngày tải lên: 28/03/2014, 23:20

... calculated per mole of Cbl. At thesametime,relationofA 280 to the molar concentra- tion of Cbl in the sample [25] gave the value of e 280 ¼ 61 900Æ M )1 Æcm )1 , which was quite close to the theoretically ... absorption of vitamin B 12 facilitating its internalization [2,3,5]. Lack or malfunction of this Cbl binder hampers the uptake of the minute amounts of the vi...

Ngày tải lên: 21/02/2014, 00:20

... dramatically decreased by the deletion of GC-box1. The activity was further decreased by the deletion of GC-box2 (Fig. 3B). As shown in Fig. 3C, the transcriptional activity of the 1 kb of the 5¢-flanking ... by the deletion of GC-box3, the GC-rich Fig. 1. Alignment of the 5¢-nucleotide sequences of the human, rat and mouse NOX4 genes. The numbers on the l...

Ngày tải lên: 29/03/2014, 00:20

... cells Endothelial cells Factor XIa Factor XIIa Fig. 7. Hypothetical model for the activation of pro-MSP. There may be diverse pathways for the activation of pro-MSP, and pro-MSP might share the activation ... mechanical wound in the dorsal skin of mice and examined the infiltration of macro- phages by measuring the CD68 mRNA level. One day after injury, the levels of...

Ngày tải lên: 29/03/2014, 23:20

... for the opposite-base specificity of Fpg and OGG1. Also, although the buffering capacity of KGlu at pH 7.5 is much weaker than that of KP i , the omission of KP i had a rather minor effect on the ... strength, the concentration of diva- lent cations such as Mg 2+ , the nature of the buffer- ing agents, the presence of competing polyamines and other small molecules...

Ngày tải lên: 18/02/2014, 18:20

... Another way of classifying ap- proaches is based on the learning aspect during the construction of the morphological model. If the data for training the model has the same struc- ture as the ... characteristics of both algo- rithms based on the experimental results. 1 Introduction Words are often considered as the smallest unit of a language when examining the gram...

Ngày tải lên: 20/02/2014, 04:20

... FAS is the enzyme responsible for the synthesis of palmitate, the precursor of FFAs. The inhibition of signaling by trophic factors, removal of trophic factors or inhibi- tion of fat synthesis ... role in the maintenance of cell survival, but is also responsible for the up-regulation of glucose metabo- lism and the induction of lipogenesis [37–40]. We hypothesize...

Ngày tải lên: 07/03/2014, 00:20

... modulates the inducible con- formational properties of SRE [23,24]. The origin of the adequate conformational deformation of the CArG boxes lies in the polymorphism of the (A ⁄ T) domain. Yet within the ... double mutations affect binding of the proximal core-SRF subunit to the first half-site of the CArG box. As a matter of fact, the structure of the...

Ngày tải lên: 07/03/2014, 09:20

... kcalÆmol )1 for MbtLS ⁄ TS50. The analysis of the thermodynamic parameters of the different inhibitors clearly showed an increase of the affinity (decreasing of DG) of the compounds bear- ing the alkyl phosphate ... to the periphery of the act- ive site is restricted by the position of Arg128 from one side and the conformation of the loop connecting b4 wit...

Ngày tải lên: 07/03/2014, 11:20

... estimate of the effectiveness of the linker in modulating the ribonucleo- lytic activity and, in essence, provides a measure of the therapeutic index of a ribonuclease zymogen. For the 1C zymogen, the ... 105 for the 1C zymogen and 13 for the 2C zymogen. Overall, the disulfide bond formed between the cysteine residues in the linker of the 2C zymogen seems to...

Ngày tải lên: 07/03/2014, 11:20