Báo cáo khoa học: TNFR1-induced activation of the classical NF-jB pathway Harald Wajant1 and Peter Scheurich2 pptx
Báo cáo khoa học: TNFR1-induced activation of the classical NF-jB pathway Harald Wajant1 and Peter Scheurich2 pptx
... at the edge of the - - Fig. 1. Activation of classical and alternative NF-jB signaling. The classical NF-jB pathway can be activated by a broad range of stimuli, including most ligands of the ... [1,2]. The two mechanisms of NF-jB dimer inhibition correspond to the existence of two different NF-jB- activating path- ways called the classical and...
Ngày tải lên: 28/03/2014, 23:20
Báo cáo khoa học: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant Mark Wehner and Christian Herrmann doc
... coefficients of 2.4 and 1.9 and dissoci- ation constants (K d Hill ) of 4 and 2 lm for hGBP5a ⁄ b and hGBP5ta, respectively. The proteins are very similar in terms of their enzymatic activity, so the ... manner, the entropic contributions of nucleotide binding and the coupled oligomerization show opposing signs. In the case of hGBP1, release of water from the...
Ngày tải lên: 15/03/2014, 10:20
Báo cáo khoa học: CpG methylation of the CENP-B box reduces human CENP-B binding pptx
... CENP-B and the unmethylated CENP-B box DNA at sites 1 and 3. The pink dotted line in the right panel indicates the hydrogen bond between the side chain NH 2 group of Arg125 and the N7 atom of guanine. Y. ... and the N7 atom of guanine 16 by the CpG methylation may be a reason for the reduced specificity of CENP-B to the CENP-B box sequence. What is the fun...
Ngày tải lên: 16/03/2014, 18:20
Tài liệu Báo cáo khoa học: Quantitative analysis of the experimental O–J–I–P chlorophyll fluorescence induction kinetics Apparent activation energy and origin of each kinetic step Steve Boisvert, David Joly and Robert Carpentier doc
... depends on the relative amplitude and rate constant of the J–I phase compared to the amplitudes and rate constants of the two other phases. The above should be gov- erned by the balance between the ... when the temperature is raised. The effect of DCMU on the traces was to increase the amplitude of step J with the concurrent decline of step I, and to re...
Ngày tải lên: 19/02/2014, 05:20
Báo cáo khoa học: Lid L11 of the glutamine amidotransferase domain of CTP synthase mediates allosteric GTP activation of glutaminase activity docx
... analysis of the structure of the T. thermophilus enzyme [15], it is suggested that the binding of ATP and UTP to the enzyme brings together the GATase and the synthase domains and enables the formation ... glutamine hydrolysis and GTP activation of this reaction. The uncoupled glutaminase activity of both these mutant enzymes no longer responds to the pre...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: Alanine screening of the intracellular loops of the human bradykinin B2 receptor – effects on receptor maintenance, G protein activation and internalization pdf
... the respective construct name next to them. The point mutations E66A in the first loop and T242A at the end of the third loop are also indicated. The two-dimensional structure of B 2 R, with the membrane ... expres- sion of the constructs under the control of the CMV promoter; filled columns, HA-tagged constructs under the control of the weaker P min promoter...
Ngày tải lên: 29/03/2014, 23:20
Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
... identify the active site residues involved in the binding of Glc to the super-open state (Fig. 1C) of this two domain [large (L) and small (S)] enzyme, and thus the site of initia- tion of the global ... [27–29]. Two of these (Y214C and Y215A) are localized in helix 6 and three (V455M, A456V and A460R) in helix 17, and some of these missense mutations (e.g. Y...
Ngày tải lên: 30/03/2014, 04:20
Báo cáo khoa học: "Quantitative modeling of the neural representation of adjective-noun phrases to account for fMRI activation" doc
... model and the multplicative model. The adjective model assumes that the meaning of the composition is the same as the adjective: u p = The noun model assumes that the meaning of the ... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 638–646, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP Quant...
Ngày tải lên: 30/03/2014, 23:20
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... ligands in the Mn-reconstituted enzyme and an additional water oxy- gen, which, together with the OD2 of Asp165, the NE2 of His79 and the NE2 of His169, formed an equatorial plane (Fig. 3B). The metal ... inhibi- tion of the binding of the superoxide substrate and the other to product inhibition by hydrogen peroxide. There are two mechanisms proposed for the...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... this RNR and that of other class 1 RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E. We consider the first option unlikely. Under these ... man- ganese in the transcriptional regulation of the nrd operon [35] may not be considered in the light of the results obtained in the present study. Rather, the...
Ngày tải lên: 15/02/2014, 01:20