Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx

... such as hyperten-sion, heart attack, and stroke.Nevertheless, the paradigms of the molecular basis of the functional regulation of Npr1 and the mecha-nisms of ANP–NPRA action are not yet clearly ... understanding of the normal and abnor-mal control of cellular and physiological processes.Although there has been much appreciation of the functional roles of natriuretic peptides and their cog-nate ... ª 2011 The Author Journal compilation ª 2011 FEBS 1807MINIREVIEW The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms Kailash N. PandeyDepartment...

Báo cáo khoa học: From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 (Heidelberg, Germany) Sergii Ivakhno pot

... some of the talksrepresenting different areas of functional genomics, networks and systems biology.Analysis of regulatory elements in the genomes of higher eukaryotes The ﬁrst session of the ... comprise 1% of the genome. Birney’s talk empha-sized the problem of mapping TF-binding sites and other elements that regulate transcription. Standardiza-tion of the protocols and comparison of different ... explore the keyparameters that determine the stability of cellularmemory, the galactose network of yeast was usedas a model system. One of the advantages of thisS. Ivakhno Functional genomics and...

Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"

... contributionsMG, GC and EW participated in the collection and interpreta-tion of the data and were involved in drafting the manuscript.MG participated in analysis and interpretation of the data and in drafting ... and in drafting the manuscript. PS, JS and MV contributed to the conception and design of the study and manuscript revision.JK was involved in the design and statistical analysis of the study. MS ... University of Amsterdam, Amsterdam, The Netherlands2Resident, Departments of Intensive Care Medicine and Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands3Resident,...

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... footprinting.Loss of the two pocket proteins leads to deregulation of the B-Myb promoter during the cell cycle. Re-intro-duction of p107, and to some extent also p130, causesrepression of the B-Myb ... located upstream of the CDE-like site [46].These observations and the fact that activation doesnot rely on CCAAT-boxes, NF-Y or Sp1 proteins,leave open the question of whether the BUB1B pro-moter ... that the exact binding location is not identiﬁed in the experi-ments. Therefore, it is not clear whether the CDE ⁄ CHRis involved in binding these factors.Consistent with a function of p107 and...

Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: intersubunit interactions during virus assembly doc

... helix 8 of the CTDwhich pack against the N-terminal end of helix 4 of the NTD of a neighboring subunit in the hexamer.Additional contacts involve helix 11 of the CTD and the C-terminal end of helix ... mutationsTrp184Ala and Met185Ala). The X-ray model of the NTD hexamer from MLV, the superimposed model of the NTD hexamer fromHIV-1, the high-resolution X-ray model of the modiﬁedCA hexamer from HIV-1, and the ... [32], and of the mature capsids of differentretroviruses; (c) the different structural organization of CA in the immature and mature capsids, including the arrangement and spacing of the hexameric...

Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: designing inhibitors of capsid assembly ppt

... disrupting the assembly of the virion capsidinvolves targeting the whole CA protein and regionsclose to the CTD. Thus, these peptides and smallorganic molecules, together with the structures of the complexes ... to the sequence of the dimerization helix of CTD (see above). CAI is the ﬁrstreported peptide able to inhibit the assembly of the mature HIV-1 capsid in vitro. However, because of the lack of ... folding of both the CAI peptide and a-helix 9 of CTD during formation of the peptide protein and protein–protein complexes.These NMR experiments also allowed the determina-tion of the CTD binding...

Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx

... biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforminggrowth factor b (TGFb) ⁄ BLP superfamily. The role of the 263 amino acids of the pro -peptide is ... beenshown. The pro -peptide of BMP-4 is responsible forstabilization of the mature part, intracellular trafﬁck-ing and folding in the endoplasmic reticulum [19–21].Thus, the roles of the pro-peptides ... interested in the role of the 263amino acid pro -peptide of BMP-2, because evidenceaccumulated over recent years has shown that the pro-forms of growth factors can modulate the activities of the mature...

Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

... Indeed, the enzymestands at a branch point of the tryptophan to NAD pathway, and deter-mines the ﬁnal fate of the amino acid, i.e. transformation into PA, com-plete oxidation through the citric ... Therefore, the available structural data suggestthat the minimal functional unit in the ACMSDenzyme is a monomer. and the biological signiﬁcance,if any, of the loose dimer observed in the crystallinestate ... centre and the ligand binding site The hACMSD active site is located in a crevice on the protein surface at the C-terminal opening of the b-bar-rel (Fig. 2), with a Zn2+ion occupying the metalcentre...

Tài liệu Báo cáo khoa học: The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of a- and b-chitin doc

... example of the role of family 33 CBPs in the deg-radation of recalcitrant polysaccharides. Furthermore, the results provide the ﬁrst example of a family 33CBP that promotes the degradation of a-chitin, ... after 2 min of incubation with 1 nM of enzyme. The double peaks represent the a- and b-anomers of the oligomers. Using standardcurves, the total concentrations of dimer, trimer and tetramer ... shown in the ﬁgure. (C) Time course of the degradation of (GlcNAc)3(r) and (GlcNAc)4( )byLlChi18A, illustratedby the production of (GlcNAc)2during the initial linear phase of the degradation...

Tài liệu Báo cáo khoa học: The intracellular region of the Notch ligand Jagged-1 gains partial structure upon binding to synthetic membranes docx

... 5329presence of SDS micelles. At a lower pH, the appear-ance of both the HSQC and the 1H-15N HSQC-TOCSY spectrum is markedly different. Most of the expected HN cross-peaks (93%) and of the Ha ... in the HN region as well asin the methyl region (data not shown) is an indicator of the lack of globular structure, and of little, if any,secondary structure [15]. The presence of strong and sharp ... not shown). The lack of signiﬁcantchemical shift dispersion in the HN and Ha chemicalshifts is an evidence of lack of tertiary structure. On the other hand, NMR spectra suggest that the confor-mation...

Xem thêm