Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx
Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx
... such as hyperten- sion, heart attack, and stroke. Nevertheless, the paradigms of the molecular basis of the functional regulation of Npr1 and the mecha- nisms of ANP–NPRA action are not yet clearly ... understanding of the normal and abnor- mal control of cellular and physiological processes. Although there has been much appreciation of the functional r...
Ngày tải lên: 28/03/2014, 23:20
Báo cáo khoa học: From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 (Heidelberg, Germany) Sergii Ivakhno pot
... some of the talks representing different areas of functional genomics, networks and systems biology. Analysis of regulatory elements in the genomes of higher eukaryotes The first session of the ... comprise 1% of the genome. Birney’s talk empha- sized the problem of mapping TF-binding sites and other elements that regulate transcription. Standardiza- tion of...
Ngày tải lên: 30/03/2014, 09:20
Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"
... contributions MG, GC and EW participated in the collection and interpreta- tion of the data and were involved in drafting the manuscript. MG participated in analysis and interpretation of the data and in drafting ... and in drafting the manuscript. PS, JS and MV contributed to the conception and design of the study and manuscript revision. JK was involved...
Ngày tải lên: 25/10/2012, 10:39
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... footprinting. Loss of the two pocket proteins leads to deregulation of the B-Myb promoter during the cell cycle. Re-intro- duction of p107, and to some extent also p130, causes repression of the B-Myb ... located upstream of the CDE-like site [46]. These observations and the fact that activation does not rely on CCAAT-boxes, NF-Y or Sp1 proteins, leave open the que...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly doc
... helix 8 of the CTD which pack against the N-terminal end of helix 4 of the NTD of a neighboring subunit in the hexamer. Additional contacts involve helix 11 of the CTD and the C-terminal end of helix ... mutations Trp184Ala and Met185Ala). The X-ray model of the NTD hexamer from MLV, the superimposed model of the NTD hexamer from HIV-1, the high-resol...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly ppt
... disrupting the assembly of the virion capsid involves targeting the whole CA protein and regions close to the CTD. Thus, these peptides and small organic molecules, together with the structures of the complexes ... to the sequence of the dimerization helix of CTD (see above). CAI is the first reported peptide able to inhibit the assembly of the mature HIV-...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
... biological function of the pro-form of bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor b (TGFb) ⁄ BLP superfamily. The role of the 263 amino acids of the pro -peptide is ... been shown. The pro -peptide of BMP-4 is responsible for stabilization of the mature part, intracellular traffick- ing and folding in the endoplasmic retic...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... Indeed, the enzyme stands at a branch point of the tryptophan to NAD pathway, and deter- mines the final fate of the amino acid, i.e. transformation into PA, com- plete oxidation through the citric ... Therefore, the available structural data suggest that the minimal functional unit in the ACMSD enzyme is a monomer. and the biological significance, if any, of the...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of a- and b-chitin doc
... example of the role of family 33 CBPs in the deg- radation of recalcitrant polysaccharides. Furthermore, the results provide the first example of a family 33 CBP that promotes the degradation of a-chitin, ... after 2 min of incubation with 1 n M of enzyme. The double peaks represent the a- and b-anomers of the oligomers. Using standard curves, the total conc...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: The intracellular region of the Notch ligand Jagged-1 gains partial structure upon binding to synthetic membranes docx
... 5329 presence of SDS micelles. At a lower pH, the appear- ance of both the HSQC and the 1 H- 15 N HSQC- TOCSY spectrum is markedly different. Most of the expected HN cross-peaks (93%) and of the Ha ... in the HN region as well as in the methyl region (data not shown) is an indicator of the lack of globular structure, and of little, if any, secondary structu...
Ngày tải lên: 18/02/2014, 16:20