Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx

... compilation ª 2011 FEBS 1443 MINIREVIEW Hyaluronan–CD44 interactions as potential targets for cancer therapy Suniti Misra 1 , Paraskevi Heldin 2 , Vincent C. Hascall 3 , Nikos K. Karamanos 4 , Spyros ... CD44v6 is expressed in breast, cervical and colon cancers, and in squamous cell carcinomas. Thus CD44v was chosen as a model for therapy. A Phase 1 clinical trial was per...

Ngày tải lên: 28/03/2014, 23:20

... same formal framework, and RTG-based algorithms (e.g., for redundancy elimination) would apply equally to dominance-based and chart-based approaches. In- deed, for one particular grammar formalism ... rules for USRs of increasing sizes in the Rondane treebank (see Sect. 4.3); the bars represent the number of sentences for USRs of a certain size. Even for the most ambiguous sentence,...

Ngày tải lên: 23/03/2014, 17:20

... Annotated Syntax Tree (AST) and Phrase Levels (PL). The hierarchical AST can be represented by a set of phrase levels, such as L] through L8 in Figure 1. Formally, a phrase level (PL) is a set ... feature structure associated with node A. Because an AST preserves both syntactic and semantic information, it can be converted to other deep structure representations easily. There- fore...

Ngày tải lên: 20/02/2014, 21:20

... Identification of Aspectual Classes (Dorr and Jones, 1996; Dorr, To appear) and as- signed LCS templates from a database built as Lisp- like structures (Dorr, 1997). The assignment of as- pectual ... the measure phrase (for terap ,) which was previously available. though not employed, as a mechanism in our database. Thus, we now have a lexicalized exam- pie of 'doing some...

Ngày tải lên: 22/02/2014, 03:20

... noun phrases. Such weak interpretation is use- ful for tasks like information retrieval, document classification, and thesaurus extraction, and indeed forms the basis in the CLARIT system for ... the formulas: When /;'(W1,W2) increases, S(W1,W2) de- creases; When DF(W1, W2) increases, S(Wx, W2) de- creases; When AvgLDF(W~, W2) or AvgRDF(W~, W2) increases, S(W1, W2) increas...

Ngày tải lên: 17/03/2014, 09:20

... to employ various techniques for reducing the human effort, such as simplifying rules based on linguis- tic information and machine learning approaches. Our effort for the robustness is focused ... domain-specific information for question answering from Web pages and stores the information into the relational database. For the domain portability, the Web IE component is based on the...

Ngày tải lên: 31/03/2014, 01:20

... enzymes, such as pectin esterases, polygalacturonases, xylanases, pectato lyases and cellulases, is another essential process for colonization and pathogenicity [2]. With the increase in genomic ... Proteo ˆ micas e Bioquı ´ micas, Po ´ s-Graduac¸a˜o em Cie ˆ ncias Genomicas e Biotecnologia, Universidade Cato ´ lica de Brası ´ lia, Brazil 6 Departamento de Biologia, Universidade Federal d...

Ngày tải lên: 18/02/2014, 18:20

... direct in vivo evidence for its validity has been found only recently for the chicken beta-globin gene cluster (reviewed in [7]). In this case, all sequences necessary for the efficient transcription ... time is required for the formation of the complex looping structure in the case of BX-C, while a shorter time is sufficient for the establishment of the much simpler regulatory inter...

Ngày tải lên: 20/02/2014, 01:20

... and RhoA) that stimulate it directly [14–18], interactions involving other proteins, such as actin, protein kinase N, casein-kinase-2-like serine kinase and amphiphysin, Keywords hydrogen peroxide; ... protease inhib- itor cocktail at 37 °C for 20 min. The lysate was spun down at 50 000 g for 15 min. The supernatant was mixed with pre-equilibrated anti-HA affinity matrix and rocked at...

Ngày tải lên: 20/02/2014, 01:20

... °CÆmin )1 was therefore preferred for subsequent experiments with GT TFOs. Padlock formation with TC oligonucleotides The use of TC TFOs has not been previously described for the formation of ... (USB, Cleveland, OH, USA) (1 U for XmnI, 12 U for DraIII, 2.5 U for XbaI) and incubating for 2 h at 37 °C. Phospha- tase was inactivated for 20 min at 65 °C. DNA was then ethanol precip...

Ngày tải lên: 20/02/2014, 03:20