Báo cáo khoa học: Control of nuclear receptor function by local chromatin structure doc

... (2007) Identifica- tion and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799–816. Nuclear receptor regulation by chromatin M. Wiench et al. 2228 ... al. Nuclear receptor regulation by chromatin FEBS Journal 278 (2011) 2211–2230 Journal compilation ª 2011 FEBS. No claim to original US government works 2229 MINIREVIEW C...

Ngày tải lên: 28/03/2014, 22:21

... 4842–4851 ª 2005 FEBS 4851 R. N. Pike et al. Control of the coagulation system by serpins MINIREVIEW Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans Robert ... examine the basic elements of the structure and function of the serpins involved in con- trolling the central coagulation enzyme, thrombin, and their control b...

Ngày tải lên: 20/02/2014, 02:21

... presence of amino acid(s) resulted in inhibition of the DNA binding of the involved transcription factors. By contrast, the presence of amino acid may also result in stimulation of the DNA binding of ... promote the changes in the chromatin structure required to enhance transcription of amino acid-regulated genes. The mechanism(s) of detection of amino acid limita- tio...

Ngày tải lên: 07/03/2014, 00:20

... and uPAR possibly through suppression of upstream targets of ERK. Thus, one of the functions of bikunin is the regulation of uPA synthesis and uPA binding by modulat- ing uPAR. It is most likely ... Y. & Terao, T. (2001) Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of...

Ngày tải lên: 17/03/2014, 11:20

... the presence of various concentrations of 2A2 mAb. The binding of 2A2 mAb was followed by native gel elec- trophoresis. Increasing the concentration of 2A2 mAb at a fixed molar ratio of cathepsin ... & Bjork I (2000) Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of...

Ngày tải lên: 18/02/2014, 11:20

... the insulin receptor indicates colocalization (as demonstrated by the yellow colour) of IRS1 with both caveolin and the insulin receptor. To further examine a caveolar localization of IRS1 we next ... [27]. Insulin receptor signalling in caveolae We next examined the functional status of caveolae- localized receptors. After incubating cells with a submax- imal concentration of...

Ngày tải lên: 23/03/2014, 12:20

... terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. ... membrane [2]. The subunits of complex IV encoded by nuclear DNA (nDNA) do not harbor enzymatic activity but function in the structural integrity, regulation and dimerization of th...

Ngày tải lên: 07/03/2014, 00:20

... ATGFβ Recycling Recycling AB C Fig. 1. Control of TGFb and activin ⁄ nodal receptor trafficking by small GTPases. (A) The role of Rab5 and Rab11 in TGFb receptor endocyto- sis and recycling. The cycling of Rab5 between ... motility. Rab7 localizes to the late endocytic compartment and controls the trafficking of late endosomes [61]. Therefore, conver- sion of Rab5 to Rab7 cont...

Ngày tải lên: 07/03/2014, 01:20

... mechanisms control- ling the functional activities of GRIP1. They extend our understanding of the importance of the structural status of GRIP1 in modulating NR functions. Results Autoregulation of GRIP1 ... activities and nuclear receptor co-activator functions. Abbreviations ACTR, activator for thyroid hormone and retinoid receptors; AD, activation domain; AF, activation fun...

Ngày tải lên: 07/03/2014, 12:20

... cDNA of LEPRb, phosphorylation of STAT1, STAT3, STAT5 and the ERK kinases was induced by leptin. The weak response of STAT5 to leptin compared to that elicited by GH can be partially explained by ... C-terminal of the phosphotyrosine are important for binding of SH2 domains [55a]. Equivalent results have been obtained by mutational analysis of the STAT binding motif of t...

Ngày tải lên: 07/03/2014, 16:20