Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt
Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt
... FEBS
MINIREVIEW
Tec family kinases: regulation of FceRI-mediated mast-cell
activation
Wilfried Ellmeier, Anastasia Abramova and Alexandra Schebesta
Division of Immunobiology, Institute of Immunology, ... during mast-cell activation. Tec fam-
ily kinases (TFKs) represent another class of protein
tyrosine kinases that are implicated in FceRI-mediated
mast-cell ac...
Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
... implicating Tec
kinase signaling in multiple levels of regulation of
cytokine production.
Itk and the regulation of cytokine-
producing innate T-cell populations
The contributions of TFKs to peripheral ... major activa-
tor of the Ras–Raf–ERK pathway in T cells. Mutation
of Itk prevents full activation of Ca
2+
mobilization
and ERK activation – these defects are worsen...
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... Tec family kinases Itk and Rlk ⁄ Txk in T lym-
phocytes: cross -regulation of cytokine production and
T cell fates. FEBS J 278, 1980–1989.
41 Qi Q, Kannan AK & August A (2011) Tec family
kinases: ... cells, the expression of ITK is extremely low
and often undetectable in immunoblot analysis. The
activation of CD4
+
cells, however, dramatically
induces transcription of...
Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx
... (2011) Tec
family kinases: regulation of FceRI-mediated mast-cell
activation. FEBS J 278, 1990–2000.
4 Schwartzberg P, Finkelstein L & Readinger J (2005)
Tec- family kinases: regulators of T-helper-cell ... results in the development of i NKT ab and cd T cells. Note that in the case of the TCR, these pathways seem to be
shared (negative regulation of PLZF, po...
Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
... large amounts of ECM leading finally to liver
fibrosis [33].
A number of reports have demonstrated an impor-
tant role of miRNAs during the activation of HSCs.
Thus, measurement of the changes ... development of diabetic nephropathy through
the down -regulation of PTEN and the subsequent acti-
vation of Akt (Fig. 1) [43]. Increased expression of
miR-377 is also thought to r...
Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... transcriptional
activation of p53, thereby potentiating the expression
of pro-apoptotic target genes [21]. The apoptotic signal
can be additionally boosted through the p53-dependent
upregulation of PML ... leads to subsequent activation of
c-Abl and facilitates p73 transcriptional activation
through c-Abl-mediated phosphorylation of p73 at
Tyr99 [60]. In addition, a key regula...
Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot
... Because of the recent discovery of GnRH-II
as a new isoform of GnRH, the majority of the studies
have been done on the GnRH-I promoter, and there
are only a few regarding regulation of the GnRH-II
gene.
The ... peptide of the GnRH neuropeptide family, being
present in animals from jaw fish to humans. The highly
conserved amino acid sequence of GnRH-II in a wide
range of spec...
Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... ell-specific dysregulation of the
levels of CB1 m RNA. The overall goal of this research was
to determine how expression of mutant huntingtin selec-
tively alters the steady-state mRNA levels of specific
transcripts ... primary cause of
HD. Examination o f t he regulation of individual m utant
huntingtin-affected genes such as CB1 may increase our
understanding of at least o n...
Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx
... formation of the stem–loop structure
impair binding of pRNA to TIP5 and abolish nucleo-
lar targeting of NoRC [69].
Analysis of the silencing capacity of wild-type or
mutant forms of pRNA revealed ... level of regulation of Pol I transcrip-
tion, at which TIF-IA not only senses external signals
but also translates changes in intracellular energy
supply into upregulation or d...
Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx
... [51].
Gα
αβγ
GPCRAgonist
βγ
G
α
No Effect
G
βγ
Effectors
Activation of
GTPase of
tubulin by
G
α
, and
inhibition of
Loss of GTP
cap on MT end
by G
α
promo
tes
catastroph
y
di i
Promotion of
MT assembly
by G
βγ
GTP-Tubulin
MT ... to
promote the GTPase activity of tubulin and subsequent
regulation of microtubule assembly [19]. Thus, the
modulation of microtubule as...