Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt

Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt

Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt

... FEBS MINIREVIEW Tec family kinases: regulation of FceRI-mediated mast-cell activation Wilfried Ellmeier, Anastasia Abramova and Alexandra Schebesta Division of Immunobiology, Institute of Immunology, ... during mast-cell activation. Tec fam- ily kinases (TFKs) represent another class of protein tyrosine kinases that are implicated in FceRI-mediated mast-cell ac...

Ngày tải lên: 28/03/2014, 22:21

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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot

Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot

... implicating Tec kinase signaling in multiple levels of regulation of cytokine production. Itk and the regulation of cytokine- producing innate T-cell populations The contributions of TFKs to peripheral ... major activa- tor of the Ras–Raf–ERK pathway in T cells. Mutation of Itk prevents full activation of Ca 2+ mobilization and ERK activation – these defects are worsen...

Ngày tải lên: 28/03/2014, 22:21

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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... Tec family kinases Itk and Rlk ⁄ Txk in T lym- phocytes: cross -regulation of cytokine production and T cell fates. FEBS J 278, 1980–1989. 41 Qi Q, Kannan AK & August A (2011) Tec family kinases: ... cells, the expression of ITK is extremely low and often undetectable in immunoblot analysis. The activation of CD4 + cells, however, dramatically induces transcription of...

Ngày tải lên: 14/02/2014, 18:20

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Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

... (2011) Tec family kinases: regulation of FceRI-mediated mast-cell activation. FEBS J 278, 1990–2000. 4 Schwartzberg P, Finkelstein L & Readinger J (2005) Tec- family kinases: regulators of T-helper-cell ... results in the development of i NKT ab and cd T cells. Note that in the case of the TCR, these pathways seem to be shared (negative regulation of PLZF, po...

Ngày tải lên: 28/03/2014, 22:21

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Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx

Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx

... large amounts of ECM leading finally to liver fibrosis [33]. A number of reports have demonstrated an impor- tant role of miRNAs during the activation of HSCs. Thus, measurement of the changes ... development of diabetic nephropathy through the down -regulation of PTEN and the subsequent acti- vation of Akt (Fig. 1) [43]. Increased expression of miR-377 is also thought to r...

Ngày tải lên: 15/03/2014, 11:20

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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

... transcriptional activation of p53, thereby potentiating the expression of pro-apoptotic target genes [21]. The apoptotic signal can be additionally boosted through the p53-dependent upregulation of PML ... leads to subsequent activation of c-Abl and facilitates p73 transcriptional activation through c-Abl-mediated phosphorylation of p73 at Tyr99 [60]. In addition, a key regula...

Ngày tải lên: 16/03/2014, 00:20

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Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot

Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot

... Because of the recent discovery of GnRH-II as a new isoform of GnRH, the majority of the studies have been done on the GnRH-I promoter, and there are only a few regarding regulation of the GnRH-II gene. The ... peptide of the GnRH neuropeptide family, being present in animals from jaw fish to humans. The highly conserved amino acid sequence of GnRH-II in a wide range of spec...

Ngày tải lên: 16/03/2014, 04:20

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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt

Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt

... ell-specific dysregulation of the levels of CB1 m RNA. The overall goal of this research was to determine how expression of mutant huntingtin selec- tively alters the steady-state mRNA levels of specific transcripts ... primary cause of HD. Examination o f t he regulation of individual m utant huntingtin-affected genes such as CB1 may increase our understanding of at least o n...

Ngày tải lên: 16/03/2014, 18:20

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Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx

Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx

... formation of the stem–loop structure impair binding of pRNA to TIP5 and abolish nucleo- lar targeting of NoRC [69]. Analysis of the silencing capacity of wild-type or mutant forms of pRNA revealed ... level of regulation of Pol I transcrip- tion, at which TIF-IA not only senses external signals but also translates changes in intracellular energy supply into upregulation or d...

Ngày tải lên: 29/03/2014, 21:20

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Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx

Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx

... [51]. Gα αβγ GPCRAgonist βγ G α No Effect G βγ Effectors Activation of GTPase of tubulin by G α , and inhibition of Loss of GTP cap on MT end by G α promo tes catastroph y di i Promotion of MT assembly by G βγ GTP-Tubulin MT ... to promote the GTPase activity of tubulin and subsequent regulation of microtubule assembly [19]. Thus, the modulation of microtubule as...

Ngày tải lên: 30/03/2014, 10:20

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