Báo cáo khoa học: The association of heavy and light chain variable domains in antibodies: implications for antigen specificity pot

... immunoglobulins is formed by six regions, three from the light and three from the heavy chain variable domains, which, on association of the two chains, form the conventional antigen- binding site of the ... antibody. The mode of interaction between the heavy and light chain variable domains affects the relative position of the anti- gen-b...

Ngày tải lên: 28/03/2014, 22:20

... site used by dynein intermedi- ate chain. Thus, whether the binding of viral proteins to dynein light chains displaces dynein intermediate chain and how it is performed remains to be established. Acknowledgements This ... and 649–800 are involved in intermediate chain and light intermediate chain binding respectively [11]. In the case of cytoplasmic dynein, interm...

Ngày tải lên: 14/03/2014, 22:20

... of the determinants of the user's behaviors arising from the task context. The first step in performing task analysis is to identify the objects involved in the task. In our case, these ... usefulness of the concept of a dialogue structure, about the role of the task structure in determining dialogue structure, and in the contribution of...

Ngày tải lên: 21/02/2014, 20:20

... procyanidins are not sig- nificantly absorbed in the intestinal tract, and reach the colon mainly intact [27]. They are therefore bio- available to the epithelial cells in the intestinal wall, where ... colon. Procyanidins and monomeric catechins (Fig. 1) are the main active polyphenols in grape and pine bark. The difference between grape and pine catechins and proc...

Ngày tải lên: 07/03/2014, 05:20

... consideration of the partner’s intentions and goals in the task performance. This involves longer ut- terances, and of course a larger effort; •responsibility of maintaining a known track of communication ... for the effort invested and provides a basis for the empirical testing of dialogue principles. The use of this system provides a positive and nega...

Ngày tải lên: 08/03/2014, 01:20

... luciferase experiments and in the levels of Rb mRNA; and, on the other hand, the stability of Rb protein is increased. As stated in the Introduction, Rb interacts with a variety of proteins. We selected ... caused by an increase in both the levels of retino- blastoma mRNA and the stability of the protein. The expression of the transcription factor Sp1,...

Ngày tải lên: 16/03/2014, 23:20

... characteristics of the lexical ontology MeSH, the use of a corpus to examine the problem space, the method of determining the rela- tions, the accuracy of the results, and the problem of am- biguity. The ... of the NCs they cover, paraphrasing the relation between the nouns, and seeing if that paraphrase was the same for all the NCs in the gro...

Ngày tải lên: 17/03/2014, 08:20

... because their speaking and writ- ing skills are impaired. For these patients, existing online care platforms are often not easily accessi- ble. Aphasia, for example, hampers the exchange of information ... From Figure 3, it is again clear that the Neuro-QA and Medical Wikipedia corpora outperform the other training corpora, and that of the other four, FAQ is the best-...

Ngày tải lên: 17/03/2014, 22:20

... presence of eIF4E binding sequences on the eIF4G fragment and the presence of eIF4E in the binding assay are required for more efficient Lb pro binding. As a control, we examined the binding of radiola- belled ... concomitant decrease in binding of both eIF4GI and eIF4GII. Interestingly, the introduction of a second basic resi- due (arginine in place of glutam...

Ngày tải lên: 23/03/2014, 13:20

... TACE are involved in the shedding of APP, neither ADAM is involved in the shedding of ACE. Furthermore we show that APMA can distinguish between the shedding of ACE and APP. Materials and methods Materials Isis ... the mRNA for the other ADAM, confirming the specificity of these ASOs [19]. The ASOs reduced the level of their respective proteins in cell ly...

Ngày tải lên: 30/03/2014, 14:20