Báo cáo khoa học: Understanding the complex mechanisms of b2-microglobulin amyloid assembly potx
Báo cáo khoa học: Understanding the complex mechanisms of b2-microglobulin amyloid assembly potx
... vivo. Despite the importance of these species for understanding amyloid disease, the structural and dynamicfeatures of amyloidogenic intermediates and the molecular details of howthey aggregate ... elongation of its fibrillar seeds with the wild-typeprotein, leading to the development of long straight amyloid- like fibrils (the image of the fibrils was redrawn from the cryo-EM structure of b2m amyloid ... in the BC- and FG-loops, the D-strand and the N-terminal region of the protein that presumably arise from the isomerization of Pro32 and subsequent partial unfolding of the pro-tein [67]. These...
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Tài liệu Báo cáo khoa học: Understanding the binding properties of an unusual metal-binding protein ) a study of bacterial frataxin pdf
... resonanceswithout the concomitant appearance of other signalsin other parts of the spectrum. This result could be aconsequence of the paramagnetic properties of Fe(II),or it might arise from the presence of ... Details of the superimposition of the hydrophobic core of CyaY (blue) andCyaY–Eu complex (red). The side chains of the CyaY C-terminus rearrange as a long-range effect of binding. The figure ... in the refinement. The correctness of the modelwas checked using the procheck [43] and whatcheck [44]programs. The coordinates of the higher-resolution complex models have been deposited in the...
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Tài liệu Báo cáo khoa học: "Understanding the Semantic Structure of Noun Phrase Queries" pptx
... bestIM:Type full timeIM:Title the godfatherOther the, in, that Other the, in, that Other the, in, thatTable 3: Label sets and their respective query segment examples for the intent class Movie, Job ... for se-mantic understanding of noun phrase queries. As-suming that the intent class c ∈ C of a query isknown, we cast the problem of extracting the se-mantic structure of the query into a ... goal of this work is to identify the semantic labels of IMs,i.e., the attribute names they implicitly refer to. Weuse Acto denote the set of IM semantic labels for the intent class c.OtherAdditionally,...
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Báo cáo khoa học: "Understanding the thematic structure of the Qur’an: an exploratory multivariate approach" pdf
... another than to any other profile in the data set. The profiles of G can be summarized by a vector s whose dimensionality is that of the data, and each of whose elements contains the mean of ... that the proposed methodology yields usable results in understanding the Qur’an on the basis of its lexical semantics. 1 Introduction The Qur’an is one of the great religious books of the ... significant finding of the proposed methodology. The scaling of the ‘Allah’ variable dominates all the other variables. To gain resolution for the others, ‘Allah’ was eliminated from the lexical...
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Tài liệu Báo cáo khoa học: "ON THE SYNTACTIC-SEMANTIC OF BOUND ANAPHORA ANALYSIS" potx
... takes its place at the top level of the restriction part of the every-NP, the in- definite should count as a proper ante- cedent for the pronoun on the reading where the every-NP takes ... wide-scope reading of the existential NP a book. The former corresponds to the constituent structure of (7), the latter is due to a "delayed application" of the existential NP, ... slightly different way. The two readings of (7) do not differ in the relative scope order of two quantifiers. Rather, the difference is that on the narrow scope reading, the discourse referent...
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Tài liệu Báo cáo khoa học: Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis docx
... [14]. The lack of characterization of the structural determinant of the substrate specificity of the AtdA enzyme has thus limited its development as abiocatalyst for the bioremediation of a wide ... reported which of the five genes control the substrate specificity of the AtdA enzyme. The objective of this study was to identify and probe the residues determining the activity as well as the sub-strate ... may indicate that the steric limitation of the enzyme’s binding pocket takes place in the areabetween the ortho and para positions of the aromaticsubstrate.On the basis of these results, aniline...
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Tài liệu Báo cáo khoa học: "Learning the Latent Semantics of a Concept from its Definition" pptx
... words. Therefore,missing words can be used to prune the hypothesesthat are also highly related to the missing words.Consider the hypotheses of latent vectors in ta-ble 1 for bank#n#1. Assume there ... WMF on the definitions corpus, the similarity of two senses sjand skcan be computedby the inner product of Q·,jand Q·,k.2.3 A Nuanced Sense Similarity: wmfvecWe can further use the features ... vectors. Let N(j) be the set of neigh-bor senses of sense j. then new latent vector is:Qnew·,j= Q·,j+k∈N (j)kQ·,k(2) Inner product (in-stead of cosine similarity) of the two resulting...
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Tài liệu Báo cáo khoa học: Mapping the functional domains of human transcobalamin using monoclonal antibodies pptx
... despite the absence of S-S bonds and the low number of conserved residuesin this part of the sequence. Only later did the largeN-terminal unit become involved in the binding of Cbl [13,14]. Assembly ... spanned either the second quarter of the TC sequence GQLA…TAAM(103–198) or the C-ter-minal peptide LEPA…LVSW(316–427). Proteolytic fragments of TC and the synthetic peptides were used to further ... absorbance shift of TCÆCbl [9] was alsoreproduced for the mAb3-9ÆTCÆCbl complex. In otherwords, the final organization of the Cbl binding site of TC seemed to be restored disregarding the attachedantibody...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... of these questions, we will proposea new hypothesis that describes an integrated vision of the catalytic mechanism of MPO and LPO.A brief survey of the absorption features of MPO, LPO and their ... oxidize them [19]. On the other hand, this factdoes not represent proof of the presence of one or twooxidizing equivalents on the decay product of Cpd I. The EPR spectrum of a spin-trapped radical ... pres-ence of H2O2alone, a non-physiological condition. Webelieve that the absence of direct evidence of the radical in the presence of cosubstrates limits the validity of extrapo-lating the model...
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Tài liệu Báo cáo khoa học: "Identifying the Semantic Orientation of Foreign Words" pdf
... engine. The number of hits for positive seeds, negative seeds,positives seeds near the given word, and negativeseeds near the given word are used to estimate the association of the given word to the ... polarity,hitsw,posis the number of hits returned by a com-mercial search engine when the search query is the given word and the disjunction of all positive seedwords. hitsposis the number of hits when ... al.,2010), where the attitude of participants in a discus-sion is inferred using the text they exchange.Due to its importance, several researchers haveaddressed the problem of identifying the semanticorientation...
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Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật