Báo cáo khoa học: Understanding the complex mechanisms of b2-microglobulin amyloid assembly potx

... vivo. Despite the importance of these species for understanding amyloid disease, the structural and dynamic features of amyloidogenic intermediates and the molecular details of how they aggregate ... elongation of its fibrillar seeds with the wild-type protein, leading to the development of long straight amyloid- like fibrils (the image of the fibrils was redrawn fr...

Ngày tải lên: 28/03/2014, 22:20

... resonances without the concomitant appearance of other signals in other parts of the spectrum. This result could be a consequence of the paramagnetic properties of Fe(II), or it might arise from the presence of ... Details of the superimposition of the hydrophobic core of CyaY (blue) and CyaY–Eu complex (red). The side chains of the CyaY C-terminus rearrang...

Ngày tải lên: 18/02/2014, 16:20

... best IM:Type full time IM:Title the godfather Other the, in, that Other the, in, that Other the, in, that Table 3: Label sets and their respective query segment examples for the intent class Movie, Job ... for se- mantic understanding of noun phrase queries. As- suming that the intent class c ∈ C of a query is known, we cast the problem of extracting the se- mantic struct...

Ngày tải lên: 20/02/2014, 04:20

... another than to any other profile in the data set. The profiles of G can be summarized by a vector s whose dimensionality is that of the data, and each of whose elements contains the mean of ... that the proposed methodology yields usable results in understanding the Qur’an on the basis of its lexical semantics. 1 Introduction The Qur’an is one of the...

Ngày tải lên: 08/03/2014, 04:22

... takes its place at the top level of the restriction part of the every-NP, the in- definite should count as a proper ante- cedent for the pronoun on the reading where the every-NP takes ... wide-scope reading of the existential NP a book. The former corresponds to the constituent structure of (7), the latter is due to a "delayed application"...

Ngày tải lên: 22/02/2014, 10:20

... [14]. The lack of characterization of the structural determinant of the substrate specificity of the AtdA enzyme has thus limited its development as a biocatalyst for the bioremediation of a wide ... reported which of the five genes control the substrate specificity of the AtdA enzyme. The objective of this study was to identify and probe the residues determin...

Ngày tải lên: 19/02/2014, 02:20

... words. Therefore, missing words can be used to prune the hypotheses that are also highly related to the missing words. Consider the hypotheses of latent vectors in ta- ble 1 for bank#n#1. Assume there ... WMF on the definitions corpus, the similarity of two senses s j and s k can be computed by the inner product of Q ·,j and Q ·,k . 2.3 A Nuanced Sense Similarity: wmfvec We c...

Ngày tải lên: 19/02/2014, 19:20

... despite the absence of S-S bonds and the low number of conserved residues in this part of the sequence. Only later did the large N-terminal unit become involved in the binding of Cbl [13,14]. Assembly ... spanned either the second quarter of the TC sequence GQLA…TAAM(103–198) or the C-ter- minal peptide LEPA…LVSW(316–427). Proteolytic fragments of TC and the sy...

Ngày tải lên: 20/02/2014, 01:20

... of these questions, we will propose a new hypothesis that describes an integrated vision of the catalytic mechanism of MPO and LPO. A brief survey of the absorption features of MPO, LPO and their ... oxidize them [19]. On the other hand, this fact does not represent proof of the presence of one or two oxidizing equivalents on the decay product of Cpd I. The EPR spe...

Ngày tải lên: 20/02/2014, 02:21

... engine. The number of hits for positive seeds, negative seeds, positives seeds near the given word, and negative seeds near the given word are used to estimate the association of the given word to the ... polarity, hits w,pos is the number of hits returned by a com- mercial search engine when the search query is the given word and the disjunction of all positive se...

Ngày tải lên: 20/02/2014, 05:20