CHARACTERIZATION OF IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY pot

... Guodong Chen ț Characterization of Impurities and Degradants Using Mass Spectrometry Mike S. Lee and Mingshe Zhu ț Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications pharmaceutical ... IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY TDC time-to-digital converter TGA thermogravimetric analysis TIC total-ion chromato...

Ngày tải lên: 28/03/2014, 10:20

... [24–27]. Helices A and B are antiparallel, as are C and D, and they are connected by small loops. A large loop, designated L, connects A and B helices with C and D helices, and L loops of neighboring monomers ... heat and chemicals such as urea and guanidinium chloride [24], and the degradation of ferritin in vivo is inhibited by excess iron [32]. To address questions o...

Ngày tải lên: 23/03/2014, 20:22

... result. Using the iTRAQ labeling mass spectrometry, a total of 438 proteins were identified by our proteomic platform. To better understand the roles of these identified proteins, they were grouped and ... classification of proteins identified in CRC Proteins identified by mass spectrometry were classified by subcellular location and molecular function (Fig. 3). To better underst...

Ngày tải lên: 16/02/2014, 15:20

... SA, Brandt ME. Psychophysiology of N200/N400: A review and classification scheme. Advances in Psychophysiology 1991; 4:43-106. 4. Hoffman JE. Event-related potentials and automatic and controlled ... 36:176-185. 60. Verleger R. Event-related potentials and cognition: A critique of the context updating hypothesis and an alternative interpretation of P3. Behavioral and B...

Ngày tải lên: 02/11/2012, 11:08

... of dry-cured ham consumption of the consumers involved in the present study are shown in Table 2. About 44.0% of the consumers were men and 56.0% women and most of them were aged between 20 and ... of food: Principals and practices. New York: Chapman and Hall. Macfie, H. J., Bratchell, N., Greenhoff, H., & Vallis, L. V. (1989). Designs to balance the effect of order...

Ngày tải lên: 03/04/2013, 21:07

Ngày tải lên: 12/01/2014, 22:19

... dithio- threitol and iodoacetamide, with quantification of Cys by detection of mass change of a peptide after reduc- tion and alkylation. These and other approaches have been described previously [19], and ... assistance of Mr Thomas Krick, Drs LeeAnn Higgins, Lorraine Anderson, Sudha Marimanikkuppam and Bruce Witthuhn of the Center for Mass Spectrometry and Proteom...

Ngày tải lên: 19/02/2014, 05:20

... inhibitors. Binding of 6PG and 5PR poorly affects the dissociation constant of the coenzymes, whereas binding of 4PE decreases the dissociation constant of the coenzymes by two orders of magnitude. ... coenzyme, or both NADP and substrate, 6PGDH was titrated with 6PG and 4PE in the presence of satu- rating concentrations of aPyADP and NADP, respec- tively. The titration...

Ngày tải lên: 07/03/2014, 05:20

... one rIAP band, with an apparent molecular mass of 70 kDa, was present, but two bands of 88 kDa and 75 kDa were detected as rIAP-II and rIAP-I in the duodenum. The molecular mass values of the rIAPs ... AP monomers of AP together [32]. In a vari- ety of human cancer cell lines and sera, the Kasahara AP isoform has been found to consist of heterodimers of hIAP and hPLA...

Ngày tải lên: 07/03/2014, 17:20

... identification of sites of C-terminal cleavage or the likely chemical composition of an attached ligand. Although the main purpose of the present work was to assess the utility of ion trap mass spectrometry ... AT L - ACP L and KS1 but not onto AT1, KR1, ACP1 or TE. The loading module fragment also showed two peaks, LM1 and LM2 with mass increase of 67 and 137 Da (theor...

Ngày tải lên: 16/03/2014, 18:20