... nucleosomes in the mainpeak, indicates that crosslinking is almost complete in the middle of the fibre, but some of the end-nucleo-somes are not crosslinked to the rest and thereforemust originate ... changing the structure of the nucleo-somes. Bearing in mind that the two-succinimidylgroups react independently, some lysines that normallyinteract with DNA are bound by one of these groups.Therefore, ... chromatin in which the presence of linker his-tone is questionable. Furthermore, the presence of alloligomers, with dimers up to the half the size of the original samples after digestion of the linkers,...