Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx
Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx
... relaxation
catalysed by topoisomerase I.
Keywords: topoisomerase I; SF2/ASF; camptothecin.
Eukaryotic topoisomerase I (topo I) catalyses DNA relax-
ation and plays a key role in DNA replication, transcription
and ... incubated for 30 min at 30 °C. Lanes: 1,
HindIII; 2, HindIII + htopo I; 3, HindIII + SF2/ASF; 4, HindIII +
htopo I + SF2/ASF; 5, RsaI; 6, RsaI + htopo I;...
Báo cáo Y học: Interferon-alpha inhibits Stat5 DNA-binding in IL-2 stimulated primary T-lymphocytes doc
... 269)35
phosphorylation levels in the IFN cotreated cells. Based on
these experiments it is unlikely that IFN inhibits cell cycle
activation by inhibiting the PtdIns3K pathway, however,
additional experiments ... Mannerheimintie 166, Helsinki, Finland
It has previously been shown that IFN-a is a potent inhibitor
of IL-2 indu ced proliferation in p rimary T-lymphocytes, by
selectively a b...
Báo cáo khóa học: How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase potx
... Ranter
1
1
Laboratory for Analytical Chemistry and Medicinal Physicochemistry, Faculty of Pharmaceutical Sciences, K.U. Leuven, Leuven,
Belgium;
2
Laboratory of Physiological Chemistry, Christian de Duve Institute ... Mg
2+
.The
sixfold coordinated Mg
2+
ion present in the a ctive site of
HPSP under normal physiological conditions, was replaced
by a Ca
2+
ion by using a crystallization co...
Báo cáo khoa học: Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA pot
... ethidium bromide.
Labeling proteins with protein kinase C
Fifty picomols of the indicated mutant topoisomerase I
proteins were incubated with 20 ng of protein kinase C
(Upstate Biotechnology, Inc., ... relaxation [4].
The cleavage religation reaction catalyzed by human
DNA topoisomerase I, the prototypical type IB
enzyme, is essential for many biological processes,
Keywords...
Báo cáo Y học: Novel protein phosphatases in yeast docx
... in different media, exhibit mild
defects in protein synthesis a nd are sensitive to several
protein synthesis inhibitors [49]. Multiple copies of SAL6
cause antisuppression of nonsense mutations ... characterized in the
budding yeast K luy verom yces l ac tis [40]. The protein is
highly similar to that of S. cerevisiae (93% identity) and it
has a bro ad role i n modulating multidrug r...
Báo cáo y học: "Placenta Percreta-Induced Uterine Rupture Diagnosed By Laparoscopy in the First Trimester"
... no history of Cesarean
section but had 2 spontaneous abortions treated by
dilatation and curettage.
Fluid collection during pregnancy is sometimes
considered insignificant if the vital signs ... emergent situation [5].
In conclusion, this report highlights the
significance of a history of spontaneous abortion
treated by dilatation and curettage in uterine rupture
caused by place...
Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"
... levels.
Key words: Helicobacter pylori; Reactive Oxygen Species; Mitochondrial DNA; Mutation.
Introduction
Helicobacter pylori (Hp) are Gram-negative mi-
croaerophilic bacteria. Hp infection represents ... key
factor in the etiology of various gastrointestinal dis-
eases, ranging from chronic active gastritis without
clinical symptoms to peptic ulceration, gastric ade-
nocarcinoma, and...
Báo cáo y học: "Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits"
... so we investigated the
efficacy of PSL co-administration in this study.
Statistical analysis
The grade of each histopathological finding was
analyzed by the Wilcoxon rank sum test in each ... Women’s
University.
Drugs
Navelbine
®
Injection (VNR) and Adriacin
®
Injec-
tion (DXR) were kindly provided by Kyowa Hakko
Kirin Co. (Tokyo, Japan). A 10 mg/mL vial of VNR
was diluted with...
Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... example of an inhibitory actio n by
antibiotics in vivo is the inhibition of prokaryotic protein
synthesis [15±18]. For instance, macrolide antibiotics, espe-
cially erythromycin (Fig. 1 A), are ... by
tetracycline is n egligible (Fig. 2). The sixfold stron ger
splicing inhibition by Cl-tetracycline may be explained by
the a dditional s ize and hydrophobicity introduced by the
sub...
Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... gastric lipase, and endothelial lipase [1,2]. The
primary function of LPL is triglyceride hydrolysis in
triglyceride-rich lipoproteins, such as chylomicron and very
low density lipoprotein (VLDL) ... Genetically engineered
mice lacking LPL also exhibit hypertriglyceridemia. In
addition to lipolytic activity, LPL functions as a ligand for
lipoprotein receptors, such as low density lipoprotein...