Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin Jae-Hoon Kim 1, *, Kazuki Saito 1,2 and Shigeyuki ... N- and C-terminal parts of the ligand are cross-linked to domains I and III, respectively, of the receptor [19,22]. The b sheet of EG...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo Y học: A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus doc
... Hammock 1 1 Department of Entomology and Cancer Research Center, 2 Section of Neurobiology, Physiology and Behavior, and 3 Department of Chemistry and Superfund Analytical Laboratory, University of California, ... each dose.Themicewereobservedfor24h,andeffectswereranked between 0 and 10, 0 being no effect and 10 being lethality. The inter- mediate ratings are based on the...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo Y học: Nuclear receptor-dependent transcription with chromatin Is it all about enzymes? pot
... Interestingly, the repression of NR activity by histone H1 can be relieved by the ligand- dependent phosphorylation of H1 by cdk2 (and possibly other kinases, as well), which leads to the removal of H1 from ... thyroid hormone receptor and retinoic acid receptor, have the capacity to actively repress the transcription of their target genes in the absence of their c...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... the first step of the reaction. The hydrolysis of the cyclic derivative is performed by the same groups, but their roles are reversed [23]. In a-sarcin the same roles are fulfilled by His137 and Glu96, ... by using the dinucleotide ApA as substrate [18]. Both mutant variants hydrolysed ApA. They displayed a K m value similar to that of the wild-type protein although they...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"
... of the investigated TMZ-BioShuttle Cell Cycle and Cell Death Analysis The effects on the cell viability and the cell cycle distribution were determined by DNA flow cytome- try. Flow cytometric ... figure shows the cell cycle distribution of DU 145 cells: In the left part of the figure the plot of the untreated control is demonstrated, the middle and th...
Ngày tải lên: 26/10/2012, 09:48
Báo cáo y học: "An Avian Connection as a Catalyst to the 1918-1919 Influenza Pandemic"
... the virulence of a virus is determined by: the efficiency of the hemagglutinin ability to drift; functional ability of the nueraminidase, and the immunity of the host it infects to fight the ... numbers quickly and killing the very young and very old. The association of avian influenza with the 1918 pandemic has not been determined; however, a more pr...
Ngày tải lên: 02/11/2012, 11:12
Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... by the 26S proteasome or, in certain cases, by the lysosomes/vacuole and rapidly degraded. Ubiquitination of target proteins involves a cascade of reactions catalysed by the E1, E2 and E3 enzymes. ... to incubation with another type of primary antibody. Detection of ubiquitinated proteins Ub is highly conserved among eukaryotes, as only three of 76 amino acids differ bet...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... intrathecally once daily for 7 days, starting from 1 day before CCI surgery. Evaluation of tactile allodynia and thermal hyperalgesia The paw withdrawal latency (PWL) to radiant heat and ... One of the potential ad- vantages of RNAi technologies is the ability to design precisely targeted therapeutics for almost any gene, regardless of the function of the gene pr...
Ngày tải lên: 25/10/2012, 11:48
Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... thrombocythemia (ET) and often in polycythemia vera (PV), myelofibrosis (MF) and chronic myelogenous leukemia. The risks associ- ated with thrombocythemia are thromboembolic events and bleeding, ... by in- hibition of megakaryocyte colony development, thereby reducing megakaryocyte size and ploidy, and disrupting or preventing full megakaryocyte matura- tion. However, litt...
Ngày tải lên: 03/11/2012, 10:52
Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
... transiently transfected with the respective expression plasmids and analyzed by confocal microscopy the next day. Full-length GFP-tagged TRAF4 molecules were localized in the cytoplasm and were barely detectable ... 8). Correspondingly, fluorescence of cytoplasmic T4(259–470)– YFP and full-length T4–GFP was already significantly reduced after 2 min of bleaching in a small are...
Ngày tải lên: 21/02/2014, 15:20