Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... 2002 Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase Alan D. Pemberton1, Tatyana S. Zamolodchikova2, ... wehave investigated the ability of duodenase to induce DNA synthesis in bovine pulmonary artery fibroblasts, attempting to elucidate which PAR subtype and signalling pathwaysmay be involved in ... asdescribed above.Isolation and culture of bovine pulmonary artery fibroblasts Sections of proximal bovine pulmonary artery wereobtained from the local abattoir and pulmonary artery fibroblasts isolated...
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Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx
... c-Cbl-associating protein; FRAP/mTOR, mammalian target of rapamycin;MAP, mitogen activa ted protein ; MAPK,MAP kinase, MEK, MAP/ERK kinase; PI3-kinase, phosphatidylinositol 3-kinase; PKB/Akt, ... to serine (CfiS) or anaspartate to alanine (D A) within the catalytic domain of Fig. 1. Scheme of the major insulin signalingpathways. The activated insulin receptorphosphorylates tyrosine residu ... regulatory s ubunit of phosphatidylinositol 3-kinase (PI3-kinase). Binding to p85 recruits the p110 catalyticsubunit of PI3-kinase, resulting in the activation of the PI3-kinase pathway, a necessary...
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Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"
... University of Calgary, Calgary, AB T2N 2T9, Canada3Department of Medicine, University of Calgary, Calgary, AB T2N 2T9, Canada4Alberta Kidney Disease Network, Calgary, AB T2N 2T9, Canada5Calgary ... appear to vary according to patient characteris-tics. Finally, ICU-acquired hyponatraemia and hypernatraemiaare associated with increased in- hospital mortality. Studies areneeded to establish ... hyponatraemia and hypernatraemia varies according to patient characteris-tics.• ICU-acquired hyponatraemia and hypernatraemia are associated with increased risk of hospital mortality – a dose-response...
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Báo cáo y học: " Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF"
... Research Paper Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF -A Yoshiko Ishida, Yasuyuki Goto, Takaaki Kondo, Mio Kurata, Kazuko Nishio, Sayo Kawai, Tomo ... previously [23]. Statistical analysis Statistical analysis was performed using STATA Ver. 8 (College Station, TX) statistical software. The Hardy-Weinberg equilibrium, which indicates an absence ... 1β, a potent gastric acid inhibiting proinflammatory cytokine, had a higher eradication rate relative to those with the -511CC genotype [18]. This study aimed to examine the associations of...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt
... Instrumental Analysis, Niigata University, JapanBinding of lamin B receptor (LBR) to chromatin was studie dby means o f an in vitro assay system involving recombinantfragments of human LBR and Xenopus ... GST–NKbeads at 23 °C. with a synthetic phase cytosol fractionwas examined a nd it was found that 60 min is necessary to reach a plateau of increased binding affinity (Fig. 4A) .The same preincubation ... time was applicable to experi-ments involving a mitotic phase cytosol fraction (data notshown). The binding of chromatin to GST–NK beadsalmost linearly increased with increasing chromatin con-centration...
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Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf
... were performed to testthe role of cleavages in the interdomain and autolysis loops in the inactivation of chymotrypsin. At first, D-chymo-trypsin and the interdomain and autolysis loop mutants ... mutagenesis of autolytic sitesPhe114, Tyr146 and Asn147 on the processes of autolysisand autolytic inactivation.MATERIALS AND METHODSEnzymes For practical reasons, instead of wild-type chymotrypsino-gen, ... Heat inactivation of D-chymotrypsin and D-chymotrypsinmutants. Initial reaction rates of amide hydrolysis, measured onsuccinyl-Ala-Ala-Pro-Phe-NHMec substrate, are plotted as the functionof...
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
... analysis using a Hewlett Packard G202 5A LD-TOF system mass spectro-meter and a- cyano-4-hydroxycinnamic acid as matrix.Sample preparationIt has been shown that a trifluoroacetic acid pretreatmentrenders ... C-terminal moiety, with those of the fusion domain of in uenza hemagglutinin suggests a direct mechanism of neurotoxicity.Keywords: Alzheimer disease; amyloid peptides; conforma-tional analysis; ... features can point to an enhanced flexibility or possibly a break in the helix.Structure calculation by a standard DYANA protocolyielded a bundle of 20 structures with satisfactory values of the target...
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Báo cáo Y học: The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme pdf
... diseases,Fig.3.Assessmentof11b-h ydroxylase a ctivity and determination of 11b-hydroxylase capacity. (A) Assessmentof11b-hydroxylase activity of CYP11B2 var iants e xpressed i n COS-1 cells. Cells were cotrans-fected ... duplicate. (B) Determination of 11b-hydroxylase capacity of CYP11B2 mutants in relation to the wild-type enzyme, whenincubated with 11-deoxycortisol. The 11b-hydroxylation of 11-deoxycortisol catalysed ... 41–62.44. Fisher, A. , Fraser, R., Mc-Connell, J. & Davies, E. (2000) Aminoacid residue 147 of human aldosterone synthase and 11beta-hydroxylase plays a key role in 11beta-hydroxylation. J. Clin.Endocrinol....
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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... necessaryNACA 4 Development of vital (life threatening) danger possibleNACA 5 Acute vital (life threatening) dangerNACA 6 Acute cardiac or respiratory arrestNACA 7 DeathZakariassen et al. Scandinavian ... mission” ,A0 6“Inconclusive pro-blem” ,A1 0“Chest pain” and A3 4 /A3 5 “Accidents”)andone category containing the rest, called “All Other” in the analyses. In the analysis of diurnal variations, NACAscores ... 0 to 7, zero indicatingno disease or injury, while seven indicates the patientbeing dead. NACA score was in the analyses cate-gorised as NACA 0-1, indicating a patient either withno symptoms/injuries...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... indicating a role for Ang-2 as a mediator in critically illness, the value of Ang-2 as a predictivemarker of outcome is poorly defined.The aim of this study was to investigate the independent value of ... non-redundantmediator of endothelial activation in experimental sepsis.Binding of circulating Ang-1 to the Tie2 receptor protects thevasculature from inflammation and leakage, whereas binding of Ang-2 antagonises ... following variables were found to be statis-tically significant at a 10% level in the univariate analysis andsubjected to multivariate Cox regression analysis: lactate,APACHE II score, SOFA score...
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