Báo cáo Y học: Neurotrophic signalling pathway triggered by prosaposin in PC12 cells occurs through lipid rafts doc

... FEBS Neurotrophic signalling pathway triggered by prosaposin in PC12 cells occurs through lipid rafts Maurizio Sorice 1,2 , Sabrina Molinari 1 , Luisa Di Marzio 3 , Vincenzo Mattei 1,2 , Vincenzo ... stauro- sporine (f), the protective effect of prosaposin against apoptosis was partially inhibited, indicating that the signalling pathways involved in cell death...

Ngày tải lên: 24/03/2014, 00:21

... its initial effect on protein kinases phosphorylation. The most strikingly and novel finding obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly by increased ... signaling pathways. The pro-apoptotic effect induced by ethanol was demonstrated by a strong inhibition of GPCR signaling pathway in association with a slight inhibition of JNK and...

Ngày tải lên: 31/10/2012, 15:37

... 1 encoded by PKN. Its cytoplasmic gene product is a serine/threonine-protein kinase N1 which is a member of the protein kinase C superfam- ily (http://amigo.geneontology.org/cgi-bin/amigo/ gp-details.cgi?gp=UniProtKB:Q16512). ... chain protecting groups were em- ployed: Boc(tert-butyloxycarbonyl) for Lys and Trp, Trityl(triphenylmethane) for Gln and Asn and Pbf (2,2,4,6,7-Pentamethyldih...

Ngày tải lên: 03/11/2012, 11:44

... Invertases (INVs) can in uence plant growth and development either directly (e.g. by in uencing source–sink relationships or by acting as a true regulatory protein) or indirectly via sugar signalling ... a key inter- mediate in several metabolic pathways sensitive to ADP ⁄ ATP ratios, including glycolysis, sucrose synthe- sis, the pentose phosphate pathway, cellulose biosyn- thesis...

Ngày tải lên: 15/03/2014, 11:20

... (suppressors of cytokine signalling) . SOCS-3 h as be en reporte d t o b e r apidly and transiently induced in T-lymphocytes following IL-2 stim- ulation, inhibiting Stat5 phosphorylation by interacting with Jak1 ... Stat5 DNA binding activity in the cells (Figs 3,4 and 5). The links between IL-2 signalling and activation of the cell cycle in T -cells are poorly understood. Acti...

Ngày tải lên: 31/03/2014, 15:20

... hypothesis. Fig. 5. Verification of the hypotheses for TFPI inhibitory mechanism. (A) Verification of the hypothesis of the enzyme–product complex inhibition by TFPI. Factor Xa is inhibited by ... possible intermolecular interac- tions between the proteins involved in these reactions is shown in Scheme 4. In the final inhibitory complex the enzyme, E, is bound to the first Kunitz-domain...

Ngày tải lên: 22/02/2014, 04:20

... identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical ... arrival, including clinical examinations as well as radiological evaluation, and where infection was sus- pected by the clinical doctor or indicated by blood, urine and other...

Ngày tải lên: 25/10/2012, 09:56

... According to Placental Position in Placental Previa Dong Gyu Jang, Ji Sun We, Jae Un Shin, Yun Jin Choi, Hyun Sun Ko, In Yang Park, Jong Chul Shin  Department of Obstetrics and Gynecology, ... parity, delivery methods, maternal past history (miscarriage, uterine surgery), diseases asso- ciated with pregnancy (myoma, endometriosis), pre- natal ultrasonography and the findings of sur...

Ngày tải lên: 25/10/2012, 10:56

... conditions remains to be deter- mined. The mechanism by which naringin and hesperi- din increase the thermogenic effect of p-synephrine may involve enhancing the expression of adiponectin which ... particularly in caffeine-sensitive individuals [39]. The absence of changes in blood pressure, rest- ing heart-rate and self-ratings in the four treatment groups involving p-synephrin...

Ngày tải lên: 25/10/2012, 11:04

... affected initially, and sepsis leads to severe injury in lung tissue [5]. It has been shown that pericytes in lung tissue produce proinflammatory cytokines in response to lipopolysaccharide ... serum proinflammatory cytokine (TNF-α, IL-1β) le- vels were evaluated by enzyme linked immunosor- bent assay (ELISA) using commercially available kits according to the manufacturer’s instr...

Ngày tải lên: 25/10/2012, 11:18