Báo cáo Y học: ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1 pot
Báo cáo Y học: ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1 pot
... absence of ATP, MDM2 was able to catalyse inhibition of the DNA-binding function of E2F1. However, the inhibition of E2F1 by MDM2 was stimulated by ATP, and mutation of the ATP- binding domain of MDM2 ... inhibiting the DNA-binding function of E2F1. These data are similar to the previ- ously reported inhibition of p53 function by the MDM2–HS...
Ngày tải lên: 24/03/2014, 00:21
Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt
... in the activity of the enzyme, most likely as the residue phosphorylated by ATP. Phosphorylation of Cl -ACL In order to investigate the reaction mechanism of prokary- otic ACL, we examined whether ... was then eluted with 400 m M KPB (pH 7.4). The dissociation of the subunits was confirmed by SDS/ PAGE analysis. Assay of enzyme activity ACL activity was assayed by the...
Ngày tải lên: 08/03/2014, 22:20
Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... that active PKC may exist in the nucleus of melanoma cells, and the pres- ence of active PKC isoforms in the nuclei of many cell types has been confirmed (10-12). Staining of the G361 cells ... com- pared to the empty vector control (Figure 4D). These data appear to support the hypothesis that nuclear overexpression of claudin-1 does not increase the in- vasive ca...
Ngày tải lên: 03/11/2012, 11:17
Báo cáo Y học: Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity doc
... very well defined, stabilized primarily by the hydrogen bonds of a tightly packed b-sheet. In this study, we examined the solution structure, stability, and antimicrobial activity of the thermolysin- linearized ... maintained in the thermolysin-linearized form. In the cyclic MccJ25, the stability is likely to be reinforced by the constraining strength of the circular back...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... detailed haemodynamic assessment by transpul- monary thermodilution technique (PiCCO system). Surpris- ingly, none of the measured angiogenic factors correlated with any of the haemodynamic parameters ... affinity to the extracellular domain of the Tie2 receptor, which is almost exclusively expressed by endothelial cells. Binding of the agonist Ang-1 to the Tie2 receptor p...
Ngày tải lên: 25/10/2012, 10:31
Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... funded by the German Federal Ministry of Education, Science, Research and Technology and by the State of Bavaria. The work was supported by the Competence Network Asthma/COPD funded by the Federal ... FEV 1 .This supports the hypothesis that not airway obstruction, but rather restriction is the more likely mechanism involved in the effect of BBL medication on lung funct...
Ngày tải lên: 25/10/2012, 10:45
Báo cáo y học: "Complications after spacer implantation in the treatment of hip joint infections"
... Unfortunately, the retrospective evaluation of the patients’ records did not allow any differentiation of the particular cause of the renal failure, respectively (antibiotic-impregnation of the spacer, ... available about the systemic antibiotics used in the particular cases nor the causes of the renal failure or of the allergic reactions, respectively....
Ngày tải lên: 26/10/2012, 09:53
Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"
... the generalizability of the results, and the findings may therefore not apply to the general population. The present study and the study by Gjesdal and Bratberg [10] are to our knowledge the ... obtained, the system will in those cases overwrite the codes when the information is updated. Disability pension though, always has the higher priority. In the present s...
Ngày tải lên: 26/10/2012, 10:03
Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... with cytotoxic drugs by increasing the sensitivity of the tumors to these agents. Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor efficacy of the ... viability of the cell in the event of a second BRCA mutation. Current data suggest that ATM, CHK2 and p53 may be candidate genes for these permissive mutations as impaired fun...
Ngày tải lên: 31/10/2012, 16:57
Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients
... this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominant in the patients. Their levels ... summary, the usefulness of Cys-C was compared with Cr in terms of the estimation of the steady-state serum trough concentrations of digoxin in Japanese patients. T...
Ngày tải lên: 31/10/2012, 17:08