Báo cáo Y học: ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1 pot
Báo cáo Y học: ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1 pot
... absence of ATP, MDM2was able to catalyse inhibition of the DNA-binding function of E2F1. However, the inhibition of E2F1 by MDM2 was stimulated by ATP, andmutation of the ATP- binding domain of MDM2 ... inhibiting the DNA-binding function of E2F1. These data are similar to the previ-ously reported inhibition of p53 function by the MDM2–HSP90 complex in the absence of ATP [21].However, as ATP stimulates ... folding of p53into an active form [22], we evaluated whether ATP has any influence on E2F1 inhibition by MDM2. Atitration of MDM2 in the presence of ATP stimulated the inhibitory activity of MDM2...
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Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt
... in the activity of the enzyme, most likely as the residuephosphorylated by ATP. Phosphorylation of Cl-ACLIn order to investigate the reaction mechanism of prokary-otic ACL, we examined whether ... was then eluted with 400 mMKPB (pH 7.4). The dissociation of the subunits was confirmed by SDS/PAGE analysis.Assay of enzyme activityACL activity was assayed by the coupled malate dehydrog-enase ... constant of the first citrate mole-cule was 0.057 ± 0.008 mM, binding of the first citratemolecule to the enzyme drastically decreased the affinity of the enzyme for the second molecule by a factor of...
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Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... that active PKC may exist in the nucleus of melanoma cells, and the pres-ence of active PKC isoforms in the nuclei of many cell types has been confirmed (10-12). Staining of the G361 cells ... com-pared to the empty vector control (Figure 4D). These data appear to support the hypothesis that nuclear overexpression of claudin-1 does not increase the in-vasive capacity of melanoma ... non-phosphorylated state did not cause a shift of claudin-1 to the nucleus of the cells, but mutating the PKA sites did. Mutations of either site to mimic constitutive phosphorylation resulted in cytoplasmic...
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Báo cáo Y học: Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity doc
... very welldefined, stabilized primarily by the hydrogen bonds of atightly packed b-sheet.In this study, we examined the solution structure,stability, and antimicrobial activity of the thermolysin-linearized ... maintained in the thermolysin-linearizedform. In the cyclic MccJ25, the stability is likely to bereinforced by the constraining strength of the circularbackbone.Interestingly, the stable three-dimensional ... precur-sor. In a recent study, an elegant ligation method was usedto complete the chemical synthesis of the cyclic MccJ25 [45].However, the folding of the synthetic cyclic peptide obtainedwas...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... detailed haemodynamic assessment by transpul-monary thermodilution technique (PiCCO system). Surpris-ingly, none of the measured angiogenic factors correlated withany of the haemodynamic parameters ... affinity to the extracellular domain of the Tie2 receptor,which is almost exclusively expressed by endothelial cells.Binding of the agonist Ang-1 to the Tie2 receptor promotesvessel integrity, ... established the immunoassays, performed the experiments, drew the diagrams and contributed to the manu-script. SD contributed to the idea, participated in the design of the study and contributed to the...
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Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... funded by the German Federal Ministry of Education, Science, Research and Technology andby the State of Bavaria. The work was supported by the Competence Network Asthma/COPD fundedby the Federal ... FEV1.Thissupports the hypothesis that not airway obstruction, butrather restriction is the more likely mechanism involvedin the effect of BBL medication on lung function. Forinstance, possible effects on the ... associated[5,6,9]. But most of these studies did not differentiatebetween the effect of high blood pressure and the effect of antihypertensive medication on lung function. Insteadthey defined hypertension...
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Báo cáo y học: "Complications after spacer implantation in the treatment of hip joint infections"
... Unfortunately, the retrospective evaluation of the patients’ records did not allow any differentiation of the particular cause of the renal failure, respectively (antibiotic-impregnation of the spacer, ... available about the systemic antibiotics used in the particular cases nor the causes of the renal failure or of the allergic reactions, respectively. In the latest evaluation of the PROSTALAC ... cases the aminoglycoside and in others the glycopeptide generates the nephro-toxic effect. The time of ARF manifestation might also vary strongly among the reported cases without hav-ing any...
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Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"
... the generalizability of the results, and the findings may therefore not apply to the general population. The present study and the study by Gjesdal and Bratberg [10] are to our knowledge the ... obtained, the system will in those cases overwrite the codes when the information is updated. Disability pension though, always has the higher priority. In the present study we have analysed the ... from the Central Population Register of Den-mark of 9653 people aged 18-59. Of these, 8664 par-ticipated in the survey (response rate 90%). Of these, 5940 were employees, meaning they had...
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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... with cytotoxic drugs by increasing the sensitivity of the tumors to these agents. Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor efficacy of the ... viability of the cell in the event of a second BRCA mutation. Current data suggest that ATM, CHK2 and p53 may be candidate genes for these permissive mutations as impaired functions of these genes, ... Interestingly, when either Ku-70 or Ligase IV was also mutated, the PARP-1-/- cells became resistant to the killing by DSB-inducing drugs. The underlying mechanism is that the absence of Ku70...
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Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients
... this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominant in the patients. Their levels ... summary, the usefulness of Cys-C was compared with Cr in terms of the estimation of the steady-state serum trough concentrations of digoxin in Japanese patients. The serum levels of Cys-C and ... showed the relationships between the serum levels of Cys-C and Cr in the healthy elderly subjects and patients. The serum levels of Cys-C were well-correlated with those of Cr both in the healthy...
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenbáo cáo khoa học ảnh hưởng của việc thay thế cỏ xanh trong khẩu phần bằng bã dứa ủ chua đến khả năng sản xuất của bò thịt potbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămbáo cáo y tế học đường năm 2012báo cáo y tế học đường trường mầm nonbiểu mẫu báo cáo y tế trường họcbáo cáo y tế học đường trường tiểu họcbáo cáo y tế trường tiểu họcchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM