Báo cáo khoa học: Anti-(Raf-1) RNA aptamers that inhibit Ras-induced Raf-1 activation docx

... Vienna, Austria The RNA folding problem RNA folding is the crucial process that connects RNA synthesis to RNA function. Many (non)coding RNAs and cis-acting elements within RNAs have to adopt complex ... single-stranded RNA showed that, depending on the amount of peptide added, the M. Doetsch et al. Transient RNA protein interactions in RNA folding FEBS Journal 278 (2011) 1634...

Ngày tải lên: 14/02/2014, 19:20

... two U2B"-U2A' A B CBP20-CBP80 Fig. 7. The RRM–protein RNA trimolecular complexes. (A) The U2B¢–U2A¢ RNA ternary complex [32]. (B) The CBP20–CBP80 RNA complex [36]. The RNA is shown in yellow, the RRM domain ... with RNA [28] (pdb:1fje), (C) sex-lethal in complex with RNA [31] (pdb:1b7f), (D) PABP in complex with RNA [33] (pdb:1cvj), and (E) U1A homodimer in com- plex with...

Ngày tải lên: 19/02/2014, 17:20

... was not calibrated. Kinetics were recorded with dark-adapted cells that were either treated or untreated with 10 l M DCMU (that inhibits electron flow from PSII) and thus in treated cells the F max level ... polypeptides. We conclude that the small amount of PSII core complexes that accumulate in these mutants cannot form stable supercomplexes with the peripheral antenna or that these...

Ngày tải lên: 07/03/2014, 15:20

... demon- strated that guanosine nucleotides have effects on RNA binding by PyrR that are opposite to the effects of uridine nucleotides [10]. That is, GMP and GTP decrease the affinity of PyrR for pyr RNA, ... single-base substitution RNA variants in BcBL2 examined. RNA binding to PyrR C. M. Jørgensen et al. 656 FEBS Journal 275 (2008) 655–670 ª 2008 The Authors Journal compilation...

Ngày tải lên: 16/03/2014, 06:20

... word are used as an alternate word representation. We call this representation Syn-Low, and 2) head per- colation rules are used to label each non-terminal in the parse such that each non-terminal ... split non-terminal of that word if it is not marked as head, else if the parent is marked as head we recursively check its parent until we reach the unique split non- terminal that is not...

Ngày tải lên: 17/03/2014, 00:20

... the role symbol R may be different in each hypothesis h. Assume that we want to represent two of the four concept hypotheses that can be derived from (P3), viz. Itoh-Ci-Sconsidered as a storage ... 'equipped' that relate to its PATIENT role carry over to '@B~'. After subsequent seman- tic interpretation of the entire verbal complex, '@B@' may be an...

Ngày tải lên: 17/03/2014, 07:20

... kinase activation; (b) it is insensitive to CDK9 inhibitors but suppressed in the presence of inhibitors of MAP kinase activation; (c) the immunogenicity of the IIm form matches that of RNAP II phosphorylated ... nuclear mRNA metabolism (Fig. 2). Many data point out that recognition of the CTD by the H5 antibody might be specific for RNAP II molecules engaged in mRNA synthesis. It is exp...

Ngày tải lên: 17/03/2014, 10:20

... partially a result of the fact that the term ‘sys- tems biology’ had not been used during that time. However, as we will see in the present review, also with respect to research that would now be called ... applica- tions of systems biology approaches that fit this defini- tion, we note that, on the one hand, it is completely insufficient to search for articles that explicitely state...

Ngày tải lên: 14/02/2014, 14:20

... nitrosylation of HSA-heme-Fe(III) FEBS Journal 277 (2010) 2474–2485 ª 2010 The Authors Journal compilation ª 2010 FEBS 2479 However, we cannot exclude that the observed pH effects could also reflect ... between Reductive nitrosylation of HSA-heme-Fe(III) P. Ascenzi et al. 2484 FEBS Journal 277 (2010) 2474–2485 ª 2010 The Authors Journal compilation ª 2010 FEBS haemoglobins. Part XIX. J Chem...

Ngày tải lên: 16/02/2014, 14:20

... intracellular activity include inhibition of DNA and protein synthesis, inhibition of chaper- one-assisted protein folding, inhibition of enzymatic activity, and inhibition of cytoplasmic membrane ... lysis, suggesting that there is more than one mechanism of antimicrobial action [48]. Earlier investigations have shown that indolicidin mainly reduces the synthesis of DNA, rather than RNA...

Ngày tải lên: 18/02/2014, 06:20