Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx

... novel toxin, AmmTX3 (3823.5 Da), was isolated from the venom of the scorpion Androctonus mauretanicus. It showed 94% sequence homology with Aa1 from Androctonus aus- tralis and 91% with BmTX3 from ... Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus He ´ le ` ne Vacher 1 , Meriem Alami 3 , Marcel ... culture...

Ngày tải lên: 23/03/2014, 21:20

... different animal phyla [10]. Scorpion a-toxins are classically divided into the follow- ing three groups: (a) mammal a-toxins that are highly active on mammals, and display very low toxicity to insects, e.g. ... limit the problems with backbone dihedrals of nonGly residues, we avoided to aligning the Gly residues with nonGly residues. The 40 first models (20 in each protein) were...

Ngày tải lên: 08/03/2014, 23:20

... until the first day of the study period. The staff designated to form the MET varied between participating centers because of local circumstances. The study protocol required that the MET ... had the responsibility for maintaining staff awareness. Outcomes: The primary outcome was a composite index of the incidence (events divided by the number of eligible patients ad...

Ngày tải lên: 25/10/2012, 10:39

... between terms. The first article, presented in this issue, covers the presentation and summary of data. It is unlikely that the material covered by this article will be entirely new to any reader but ... it is hoped that there will still be useful lessons to be learned, for example the underlying assumptions of a hypothesis test that were not fully appreciated, or some previously unre...

Ngày tải lên: 25/10/2012, 10:45

... Furthermore, with the advent of new DES systems, it is important to elucidate any differences in efficacy and safety when utilizing the currently availab l e DESs. Therefore, we report the ... patients in the ZES treated group were prematurely taken off their antiplatelet therapy and this likely played a role in the observed MACE events. Also noteworthy was the observation...

Ngày tải lên: 25/10/2012, 11:18

... interpreted with caution. The question is whether these apparently H. pylori-negative subjects were indeed truly negative or they eventually led to loss of the infection due to sever gastric atrophy. ... Nagoya University between January 1998 and June 2000. Informed consent was obtained from all the subjects. This study protocol was approved by the Ethics Committee of the...

Ngày tải lên: 31/10/2012, 15:37

... the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not be attributed to the presence of the Gly cluster in this element. The present study supports the idea that the ... resulted in an enzyme with slightly lower stability. On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores the stabi...

Ngày tải lên: 22/02/2014, 04:20

... guanidine hydro- chloride (GdnHCl), urea or elevated temperatures, they destroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc- ture ... triflu- oroethanol the proteolytic susceptibility of RNase A strongly increases, which coincides with the disruption of the tertiary structure of the RNase A molecule, in 20% t...

Ngày tải lên: 22/02/2014, 07:20

... previously. The nature of the multiplicity of these high-spin signals is not known, but it does not reflect a difference in enzymatic activity. As expected for heme enzymes, the ferric heme in the enzyme ... and hypochlorite. The reaction mechanism of WF10 with hemoproteins may be similar to the enzymatic reaction of chlorite with chlorite dismutase. Thus, the study of chlori...

Ngày tải lên: 08/03/2014, 16:20

... Pharmacy, University of Patras, Greece A new human/rat CRH analogue has been synthesized using the Fmoc/tBu solid-phase synthetic protocol. The sequence of the new peptide differs from the original ... 3A shows the family of 40 structures and Table 1 contains a summary of statistical data indica- ting the quality of the 40 models and the average energy- minimized structure....

Ngày tải lên: 17/03/2014, 10:20