Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx
Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx
... novel toxin, AmmTX3 (3823.5 Da), was isolated from the venom of the scorpion Androctonus mauretanicus. It showed94% sequence homology with Aa1 from Androctonus aus-tralis and 91% with BmTX3 from ... Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus He´le`ne Vacher1, Meriem Alami3, Marcel ... culture. These toxins revealed anew class of scorpion toxin binding sites in rat brain [8].In this study, a third component (AmmTX3) of this new toxin family is identified from the venom of the scorpion Androctonus...
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Báo cáo Y học: A chimeric scorpion a-toxin displays de novo electrophysiological properties similar to those of a-like toxins docx
... different animal phyla[10]. Scorpion a-toxins are classically divided into the follow-ing three groups: (a) mammal a-toxins that are highly activeon mammals, and display very low toxicity to insects,e.g. ... limit the problems with backbone dihedralsof nonGly residues, we avoided to aligning the Gly residues with nonGly residues. The 40 first models (20 in eachprotein) were screened with the programsPROCHECK[36],PROSA ... simi-larly recognized by the polyclonal antibodies raised againstBotG-50 (a partially purified mixture of Buthus occitanustunetanus venom) or BotI toxin. On the contrary, very lowcross antigenicity...
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Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... until the first day of the study period. The staff designated to form the MET varied between participating centers because of local circumstances. The study protocol required that the MET ... had the responsibility for maintaining staff awareness. Outcomes: The primary outcome was a composite index of the incidence (events divided by the number of eligible patients admitted to the ... at least the equivalent of the pre-existing cardiac arrest team and consist of at least one doctor and a nurse from the emergency department or ICU. A 6-month study period followed the 4-month...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... between terms. The first article, presented in this issue, covers the presentationand summary of data. It is unlikely that the material covered bythis article will be entirely new to any reader but ... it is hoped that there will still be usefullessons to be learned, for example the underlying assumptionsof a hypothesis test that were not fully appreciated, or somepreviously unrecognised confusion ... the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this isoften not true, with many relying on distant memories ofpoorly...
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Báo cáo y học: "Two-year Outcome of Turkish Patients Treated with Zotarolimus Versus Paclitaxel Eluting Stents in an Unselected Population with Coronary Artery Disease in the Real World: A Prospective Non-randomized Registry in Southern Turk
... Furthermore, with the advent of new DES systems, it is important to elucidate any differences in efficacy and safety when utilizing the currently availab l e DESs. Therefore, we report the ... patients in the ZES treated group were prematurely taken off their antiplatelet therapy and this likely played a role in the observed MACE events. Also noteworthy was the observation that, the lesion ... 12.8%, at the end of the two-year period. In our trial, however, the incidence of MACE in the ZES treated group was 10% at the end of the two year follow-up (Table 4). Additionally, the inci-dence...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... interpreted with caution. The question is whether these apparently H. pylori-negative subjects were indeed truly negative or they eventually led to loss of the infection due to sever gastric atrophy. ... Nagoya University between January 1998 and June 2000. Informed consent was obtained from all the subjects. This study protocol was approved by the Ethics Committee of the Nagoya University ... of the earlier presentation or diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not beattributed to the presence of the Gly cluster in this element. The present study supports the idea that the ... resulted in an enzyme with slightly lower stability.On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores the stability of the protein producing ... study [16],our interest is focused to the vicinity of the active site of the psychrophilic alkaline phosphatase from the AntarcticTable 1. Enzymatic and thermodynamic parameters of the psychrophilic...
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Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... guanidine hydro-chloride (GdnHCl), urea or elevated temperatures, theydestroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc-ture ... triflu-oroethanol the proteolytic susceptibility of RNase Astrongly increases, which coincides with the disruption of the tertiary structure of the RNase A molecule, in 20%trifluoroethanol the proteolytic ... secondary structure only after the disruption of the native tertiary structure of RNase A(Figs 2–4). Interestingly, the preservation of the tertiarystructure coincides with the activity profile of RNase...
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Báo cáo Y học: Spectroscopic characterization and ligand-binding properties of chlorite dismutase from the chlorate respiring bacterial strain GR-1 ppt
... previously. The natureof the multiplicity of these high-spin signals is not known,but it does not reflect a difference in enzymatic activity. Asexpected for heme enzymes, the ferric heme in the enzyme ... and hypochlorite. The reaction mechanism of WF10 with hemoproteins may besimilar to the enzymatic reaction of chlorite with chloritedismutase. Thus, the study of chlorite dismutase mayprovide ... dismutase. Furthermore, we investigated the binding of hydroxide and imidazole to the ferric enzyme andof NO to the ferrous enzyme to establish the nature of the proximal ligand bound to the heme...
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Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... Pharmacy, University of Patras, GreeceA new human/rat CRH analogue has been synthesizedusing the Fmoc/tBu solid-phase synthetic protocol. The sequence of the new peptide differs from the original ... 3A shows the family of 40 structuresand Table 1 contains a summary of statistical data indica-ting the quality of the 40 models and the average energy-minimized structure. The polypeptide ... and 15, at which the native amino acidsL-phenylalanine 12 andL-leucine 15 have been replacedby the nonprotein amino acidsD-phenylalanine anda-aminoisobutyric acid (Aib), respectively. The...
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