Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx

... translo- cation and in poly(U)-directed polyphenylalanine synthesis [26,27], by preventing it from binding to the ribosome [28]. Early data showed that the phosphorylation of eEF2 was increased by very low ... members of main protein kinase superfamily, Ryazanov coined the term Ôa-kinaseÕ for this unusual group of enzymes. Further discussion of this family may be found in a recent...

Ngày tải lên: 23/03/2014, 21:20

... play a critical role in progression of the cell cycle and the differentiation of cells [11,12]. The methylation of DNA plays a role in the regulation of gene expression [13,14], genomic imprinting ... University of Tokyo, Japan The Sp family is a family of transcription factors that bind to cis-elements in the promoter regions of various genes. Regulation of transc...

Ngày tải lên: 22/02/2014, 07:20

... using the Prime-a-gene labeling system (Promega). Double-positive clones were purified by secondary and tertiary r ounds of screening and genomic DNA inserts were purified using poly(ethylene glycol) ... promoter is independent of TATA-binding-protein-associated factors and initiator-binding proteins. Mol. Cell Biol. 17, 2973–2984. 32. Weis, L. & Reinberg, D. (1992) Transcription by RNA...

Ngày tải lên: 08/03/2014, 16:20

... protein con taining the RAS-b inding domain o f RAF. Precipi- tated proteins were resolved by 12.5% SDS/PAGE and analysed by Western blotting using an anti-RAS Ig (top). Proteins of whole cell lysate ... throu gh its proline rich domain to the S H3 domains of the adapter GRB2. The Src homology (SH)2 domain of GRB2 is able to bind phosphorylated tyrosine residues on tyrosine kinase recep...

Ngày tải lên: 08/03/2014, 16:20

... systems. REGULATION OF SAPK SIGNAL PATHWAYS BY PROTEIN PHOSPHATASES IN YEAST CELLS A molecular g enetic analysis of ye ast cells indicated that two distinct protein phosphatase groups, protein ... dephosphorylates Hog1 in S. cerevisiae both in vivo and in vitro [15]. REGULATION OF SAPK SIGNAL PATHWAYS BY PROTEIN PHOSPHATASES IN MAMMALIAN CELLS In mammalian cel...

Ngày tải lên: 17/03/2014, 23:20

... glycosylphophatidylinositol (GPI) anchors [1,2]. Although the primary structure of the glypi- cans is only marginally conserved (about 30% identity), there is a strict conservation of 14 cysteine ... by growth factors and cytokine [13,14]. In most cells, levels of syndecan synthesis correlate well with syndecan mRNA levels, suggesting that the regulation is mainly transcriptional [...

Ngày tải lên: 17/03/2014, 23:20

... addressed by exploring the effect of rapamycin on the control of overall rates of protein synthesis. In cell lines, rapamycin generally exerts only a small inhibitory effect on the rate of protein synthesis ... (1997) Regulation of protein kinase B and glycogen synthase kinase 3 by insulin and b-adr- energic agonists in rat epididymal fat cells. Activation of protein kinase...

Ngày tải lên: 23/03/2014, 21:20

... with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance...

Ngày tải lên: 25/10/2012, 11:48

... contributing to the efficacy of combination LAM and HBIG remain poorly defined. Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary ... or delay severity of reinfection, presumably due to the effects of HBV-specific memory cells among passenger leukocytes [91]. An initially low recurrence rate in a Chinese coho...

Ngày tải lên: 02/11/2012, 11:17

... level of the has operon containing the hyaluronan synthase gene or the protein level of hyaluronan synthase. Solubilization of the enzyme from membranes of MU-treated cells and addition of the ... pathogenicity by allowing them to escape from the immune systems of their hosts. The HA synthesized by Streptococci is not chemically or structurally distinguishable from that synthesi...

Ngày tải lên: 08/03/2014, 09:20