Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx
Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx
... translo-cation and in poly(U)-directed polyphenylalanine synthesis[26,27], by preventing it from binding to the ribosome [28].Early data showed that the phosphorylation of eEF2 wasincreased by very low ... members of main protein kinasesuperfamily, Ryazanov coined the term Ôa-kinaseÕ for thisunusual group of enzymes. Further discussion of this familymay be found in a recent review by Ryazanov ... target of rapamycin, aprotein which is discussed in more detail in the accompany-ing review by Proud [1]. Insulin has subsequently beenshown to decrease eEF2 phosphorylation in primary celltypes...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
... play a critical role in progression of the cellcycle and the differentiation of cells [11,12].The methylation of DNA plays a role in the regulation of gene expression [13,14], genomic imprinting ... University of Tokyo, JapanThe Sp family is a family of transcription factors thatbind to cis-elements in the promoter regions of variousgenes. Regulation of transcription by Sp proteins is basedon ... available dataindicate that the identification by Bigey et al.ofmanyCorrespondence to K. K. Yokoyama, Gene Engineering Division,Department of Biological Systems, BioResource Center, TsukubaInstitute,...
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Báo cáo Y học: Regulation of a1,3galactosyltransferase expression in pig endothelial cells Implications for xenotransplantation doc
... using thePrime-a-gene labeling system (Promega). Double-positiveclones were purified by secondary and tertiary r ounds of screening and genomic DNA inserts were purified usingpoly(ethylene glycol) ... promoter is independent of TATA-binding-protein-associated factors and initiator-bindingproteins. Mol. Cell Biol. 17, 2973–2984.32. Weis, L. & Reinberg, D. (1992) Transcription by RNA poly-merase ... promoterpreference remains unchanged, a1,3GalT mRNA levelsincrease by 50% in 12 h upon tumour necrosis factora-activation of P EC-A cells. However, the magnitude of thischange induced by in ammatory conditions...
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Báo cáo Y học: Regulation of RAS in human platelets Evidence that activation of RAS is not sufficient to lead to ERK1-2 phosphorylation pot
... protein con taining the RAS-b inding domain o f RAF. Precipi-tated proteins were resolved by 12.5% SDS/PAGE and analysed byWestern blotting using an anti-RAS Ig (top). Proteins of whole celllysate ... throu gh its proline rich domain tothe S H3 domains of the adapter GRB2. The Src homology(SH)2 domain of GRB2 is able to bind phosphorylatedtyrosine residues on tyrosine kinase receptors or ... ERK activation induced by thrombinis dependent on SRC kinasesSRC family kinases are necessary for the initial signallingevents induced by GPVI, notably for phosphorylation of the G PVI-associated...
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Báo cáo Y học: Regulation of stress-activated protein kinase signaling pathways by protein phosphatases pot
... systems. REGULATION OF SAPK SIGNALPATHWAYS BY PROTEINPHOSPHATASES IN YEAST CELLS A molecular g enetic analysis of ye ast cells indicated that twodistinct protein phosphatase groups, protein ... dephosphorylates Hog1 in S.cerevisiae both in vivo and in vitro [15]. REGULATION OF SAPK SIGNALPATHWAYS BY PROTEINPHOSPHATASES IN MAMMALIAN CELLS In mammalian cells, like yeast cells, both ... phosphorylation of conserved tyrosine and threonine residues within thecatalytic domain. This phosphorylation is mediated by dualspecificity protein kinases, members of the MAPK kinase(MKK) family....
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Báo cáo Y học: Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development pptx
... glycosylphophatidylinositol (GPI)anchors [1,2]. Although the primary structure of the glypi-cans is only marginally conserved (about 30% identity), thereis a strict conservation of 14 cysteine ... by growth factors and cytokine [13,14]. In most cells, levels of syndecan synthesis correlate well withsyndecan mRNA levels, suggesting that the regulation ismainly transcriptional [8].Syndecans ... signaling pathways in theSertoli cells. This hormone induces the increase of intracel-lular cyclic AMP and calcium levels.Effect of intracellular cAMP level increaseThe involvement of the...
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Báo cáo Y học: Regulation of mammalian translation factors by nutrients pot
... addressed by exploring the effect of rapamycin on the control of overall rates of proteinsynthesis. In cell lines, rapamycin generally exerts only asmall inhibitory effect on the rate of protein synthesis ... (1997) Regulation of proteinkinase B and glycogen synthase kinase 3 by insulin and b-adr-energic agonists in rat epididymal fat cells. Activation of proteinkinase B by wortmannin-sensitive and-insensitive ... alsopositively regulate autophagy [112]. Amino acids do, however,modulate the activity of eIF2B in mammalian cells. Insulin can activateeIF2B by inducing dephosphorylation of an inhibitory site in eIF2B(see...
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Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
... with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance in this ethnic ... changes of the liver in inflammation, fibrosis and fatty deposition were examined in all patients. Results: The levels of BMI, HOMA-IR, FBG, insulin, TG, and CHOL were significantly higher in patients...
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Báo cáo y học: "Management of HBV Infection in Liver Transplantation Patients"
... contributing to the efficacy of combination LAM and HBIG remain poorly defined. Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary ... or delay severity of reinfection, presumably due to the effects of HBV-specific memory cells among passenger leukocytes [91]. An initially low recurrence rate in a Chinese cohort receiving LAM ... finding of circulating HBV DNA by PCR in 2 of 11 receiving HBIG and 5 of 10 receiving LAM suggests that reinfection would be likely in additional patients with longer observation. Discontinuation of...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... level of the hasoperon containing the hyaluronan synthase gene or theprotein level of hyaluronan synthase. Solubilization of theenzyme from membranes of MU-treated cells and addition of the ... pathogenicity by allowingthem to escape from the immune systems of their hosts.The HA synthesized by Streptococci is not chemicallyor structurally distinguishable from that synthesized in mammalian cells. HA ... HA releasedinto the culture medium was measured by the sandwichbinding protein assay using hyaluronan binding protein(HABP) according to the manufacture’s instructions for thehyaluronic acid...
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