Báo cáo Y học: The group I-like ribozyme DiGIR1 mediates alternative processing of pre-rRNA transcripts in Didymium iridis pptx

... cells,suggesting an interplay between the two ribozymes of a twin- ribozyme intron.Keywords: Didymium iridis; group I intron; ribozyme; pre-rRNA processing. Group I introns contain a conserved set of ... result of DiGIR1 catalysis. The criticalinvolvement of DiGIR1 in the formation of the 5¢ end of the RNA could be tested by the introduction of mutations in the catalytic site of the ribozyme [3]. ... involved in the removal of the intron by splicing. They constitute one class out of fewerthan 10 classes of naturally occurring ribozymes [1]. Group I introns vary considerably in complexity....

Báo cáo Y học: The sodium pump Its molecular properties and mechanics of ion transport potx

... protein associated withmammary tumors. The availability of the cDNA codingfor the peptide permitted analysis of the role of the c subunit in the function of the enzyme. Consistent with the fact ... from the single-site model in that they predict the presence of two bindingsites on each functional enzyme entity. The results of manyinvestigations support the existence of two binding sites ... with the adenine moiety of the ATP molecule, butthat it is merely within reach of the highly reactive azido group of 8-azido-ATP. In the crystal structure of the Ca2+-ATPase, Lys492, the equivalent...

Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

... results as indicating the binding of the thiol sulfur of HS-CoM to the zinc atom of MtaA in a way that it replaces one of the nonsulfur ligands,possibly the oxygen of coordinated H2O or hydroxide.EXAFS ... in high-quality ﬁts. Interestingly, in Cys239 ﬁ Ala the zincseems to be penta-coordinated. These results are highlysuggestive that, in the wild-type, Cys239 is a zinc ligand. In the Cys239 ﬁ Ala ... the wild-type, the EXAFS analysis unambiguouslyindicates that HS-CoM addition results in an increase in the number of sulfur atoms in the ﬁrst coordination sphere of zinc. This increase in the...

Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"

... mortal-ity.Competing interests The authors declare that they have no competing interests.Authors' contributionsPC contributed to the design of the study, obtained data,made the analysis, interpreted ... 28-day mortality.BackgroundSepsis is a systemic inflammatory response to a confirmedor suspected infection. Clinically, the Systemic Inflamma-tory Response Syndrome (SIRS) is the occurrence of ... serology, pneumonia verified by chest X-ray,infection documented with other imaging techniques,positive urine dip test combined with symptoms of urinetract infection, or as typical clinical symptoms...

Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"

... incidence in the age group “>70years” (N = 329; 42%). Traumas were mostcommon in the age group 10-29 years, dominated byyoung males with 29% of the 399 situations in this group. In the youngest ... for 11% of the patients. The table also shows that in 26% of the situations, the casualty clinics were directly involved in patient care, either as final place of treatment or byexamination ... difficulties” was the most used Index-category in the “all other” group with nearly 5% of the total. Approximately half of all patients in the youngestage group had “all other” medical problems...

Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"

... distinct career pathway. Involving such physicians in medicalemergency teams will likely facilitate the dual roles of these as aclinical outreach arm of the intensive care unit and in identifyingproblems ... the study consisted of only a 5-minute debriefing to fill out the standardized MET form on each patient and a weekly 1-hourCommentary The evolving story of medical emergency teams in qualityimprovementAndré ... rationale for the development of METs rose from observations that, in the majority of patients, premonitory signs and symptoms of cardio-pulmonary instability are often present hours before clinicaldeterioration...

Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"

... revised the manuscript. HTS and FK had full access to all the study dataand assume responsibility for the integrity of the data and the accuracy of the analysis.References1. Himmelstein DU, ... atinception (within the first day of ICU admission) was assessedusing the APACHE II score and intensity of care using the TISS score [15,16].Patients were classified into three categories of ... andsurrounding areas (population 1.2 million) in the province of Alberta, Canada [14]. All critically ill adult patients in the CHRare managed in ICUs under the care of the Department of Crit-ical...

Báo cáo y học: "The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey"

... study performed in four year period, which included two years before and after of the initiation of NARP in 2003. The study in- cluded the data obtained from all of the four univer-sity hospitals, ... restricted for the first three days of therapy by NARP, the consumption of these quinolones was unsurprisingly high. Besides that the use of oral quinolones for maintenance may contribute to the significant ... Hospital setting and antibiotic policy: NARP was initiated in Turkey in February 2003 by a central regulation of Ministry of Health and was announced nation-wide via official newspaper of the state...

Báo cáo y học: "The Versatile Use of Temporoparietal Fascial Flap"

... the donor site is sutured using 3/0 polypropylene. Depending on the amount of drainage, the drain is usually removed on the first or second postoperative day. An informed consent explaining ... only shaved the incision line. Several incisions, such as lazy S, inverted T, Y- shaped, or zigzag incisions can be used. The inci-sion is made starting from the preauricular region extending ... Aesthetic Surgery, Dokuz Eylul University, Faculty of Medicine, Izmir, TURKEY. 2. Clinic of Plastic Reconstructive and Aesthetic Surgery, Public Hospital, Mus, Turkey. 3. Clinic of Plastic Reconstructive...

Báo cáo y học: "The Influence of Hyperbaric Oxygen Treatment on the Healing of Experimental Defects Filled with Different Bone Graft Substitutes"

... These interesting and pre-viously unreported findings suggest the necessity of multidisciplinary study designs which take into ac-count different characteristics of the tissues involved in ... Turkey 4. Istanbul University, Faculty of Medicine, Department of Histology and Embryology, Istanbul, Turkey. 5. Istanbul University, Faculty of Medicine, Department of Undersea and Hyperbaric ... Istanbul, Turkey 2. Istanbul University, Faculty of Medicine, Department of Oncologic Pathology, Istanbul, Turkey 3. Istanbul University, Faculty of Medicine, Department of Biochemistry, Istanbul,...

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