Báo cáo khoa học: Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure doc

... Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure Ryoichi Saiki, Ai Nagata, Naonori Uchida, Tomohiro ... decaprenyl diphosphate synthase. Heterotetrameric formation of Dps1 and Dlp1 That dps1 and dlp1 are both required for the decaprenyl diphosphate synthase activity suggests that Dps1 and Dlp1 might ... K., Okada, K., Kamiya, Y., Zhu, X., Tanaka, K.,Nakagawa, T., Kawamukai, M. & Matsuda, H. (1997) Analysis of the decaprenyl diphoshate synthase (dps) gene in ﬁssion yeast suggests a role of...

Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf

... transcription of genes involved in hepatic,renal, and intestinal detoxiﬁcation and genes of the innate and adaptive immune system. REV-ERBalpha, a nuclear orphanreceptor acts as a strong transcriptional ... IKKb, as a way to inhibit activation of most NF-jB forms. While in ammation is a major factor thatcontributes to the development and progression of CAC and other in ammation-linked cancers and ... activation is attenuated by ectopic expression of a dominant interfering cDNA containing two FYVE domains.S1.1-3Regulation and function of the WNK1 and WNK4 protein kinasesD. AlessiMRC Protein Phosphorylation...

Báo cáo khoa học: Docosahexaenoic acid stabilizes soluble amyloid-b protoﬁbrils and sustains amyloid-b-induced neurotoxicity in vitro ppt

... extracellular amyloidplaques and intracellular neuroﬁbrillary tangles. Pla-ques consist mainly of ﬁbrillar amyloid-b (Ab) protein, whereas tangles are composed of ﬁbrillar tau protein. The aggregation ... such as docosahexaenoicacid, with Ab, and their effect on Ab aggregation has not been explored in detail. Therefore, we have investigated the effect of docosahexaenoic acid,arachidonic acid and ... aggregation, havenot been explored in detail. Therefore, we have investi-gated the effect of unsaturated DHA and AA and the saturated fatty acid arachidic acid (20:0) on Ab mono-mer oligomerization into...

Báo cáo khoa học: "Word classification based on combined measures of distributional and semantic similarity" docx

... would be the case with a thesaurus of a realisticsize, proves to be much more challenging. For ex-ample, Alfonseca and Manandhar (2002) attain the learning accuracy' of 38% when assigning ... the original class of a test nounwas tested. Their performance was evaluated in terms of precision and in terms of learning accu-racy (Hahn and Schattinger, 1998). The latter is a measure designed ... distributional similarity of the new word to the target class and (2) the strength of the semantic relatedness of the target class toother likely candidates. Thus, using the thesaurus asbackground...

Báo cáo khoa học: "Parsing with Treebank Grammars: Empirical Bounds, Theoretical Models, and the Structure of the Penn Treebank" ppt

... frequently speak in terms of the following:span: a range of words in the chart, e.g., [1,3]4edge: a category over a span, e.g., NP:[1,3]traversal: a way of making an edge from anactive and a passive ... grammar.one instance of , every node not dominating that in- stance is an instance of an empty-reachable category. The same-span-reachability relation induces a graphover the 27 non-terminal categories. ... span in NOEMPTIES).13Therefore,phrasal categories in do not constrain whether canmatch . The real issue is whether the tags in willmatch words in . Assume that a random tag matches a random...

Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc

... speciﬁcity of protein degradation is also a plausible mechanism to explain our data. In general,not all proteins are degraded to the same extent and at the same rate. The autophagy route to degradation,which ... nitrogenstarvation, the total free amino acid levels are dramati-cally decreased. After 3–6 h, the amino acid levels and the rate of protein synthesis are partly restored [26]. The quantitative analysis ... the mechanisms actingat each level. The hierarchical regulation can bedivided into several levels, i.e. mRNA synthesis and degradation, protein synthesis and degradation and protein modiﬁcation.The...

Báo cáo khoa học: Amyloid oligomers: diffuse oligomer-based transmission of yeast prions ppt

... in the cells after the foci disappeared. The live-cell imaging showed the appearance of the foci in the daughter cell at almost same time as when the foci re-appeared in the mother cell, indicatingthat ... cytoplasm in the cells showed a slowerrate of recovery after 1 hour of incubation in GuHCl,but the rate of FRAP increased after 5 h of incubation in the GuHCl-containing medium, and became identi-cal ... Fluorescence recovery after photobleachingAs an alternative approach to analyze the protein dynamics in living cells, the diffusion of a ﬂuorescent protein can be measured using a photobleaching tech-nique...

Báo cáo khóa học: Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae potx

... ampliﬁedusing the PCR primers 5¢-TAAATCATGATAACGGGCATGACTGG-3¢ and 5¢-TTAAGGGATCCATATTCTTCTCTTTCTAAC-3¢. The genome of S. acidocalda-rius, as the template, and KOD DNA polymerase (TOY-OBO) ... radioactivity in 100 lL of the butanol layer was measured.NADH dehydrogenase assay The standard assay mixture for the NADH dehydrogenaseactivity of S. shibatae IDI contained, in a ﬁnal volume of 100 ... containing1 lmol of phenol, 1.25 lmol of 4-aminoantipyrine, and 650 mU of horseradish peroxidase, was then added. The absorbance of quinoneimine dye at 505 nm and that of NADH at 340 nm were measured...

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... containing 1) [9]. The KIND domain in theseproteins is localized to the N-terminal region, and theirspeciﬁc functional domains are located in the C-termi-nal region. The C-lobe of protein kinases ... (i.e. the MAP2-bindingcore module in v-KIND and the v-KIND-binding coremodule in MAP2) across a range of amino acid resi-dues, and provided evidence that these novel protein protein interaction ... mediates the interaction with activators, substrates and regulatorysubunits, implying that the KIND domain, an atypicalnoncatalytic C-lobe, is involved in the interaction withsignaling proteins...

Tài liệu Báo cáo khoa học: Hsp105b upregulates hsp70 gene expression through signal transducer and activator of transcription-3 pdf

... 5¢-TCT ATC TCT CGA TGGATA CAG A- 3¢; reverse, 5¢-AGG ACA GTA GAA TTAGGT CAC T-3¢).Knockdown of Hsp10 5a and Hsp105b The double-stranded RNA targeting Hsp105 (Dharmacon;5¢-GCA AAU CAC UCA UGC AAA ... Stephanou A, Isenberg DA, Nakajima K & LatchmanDS (1999) Signal transducer and activator of transcrip-tion-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and ... fromstress-induced damage by preventing protein denatur-ation and ⁄ or repairing such damage [1]. Mammalianheat shock proteins are classiﬁed into several familieson the basis of their apparent molecular weight...

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