Báo cáo khoa học: p53-induced inhibition of protein synthesis is independent of apoptosis pdf

... preparation). Thus it is unlikely that the regulation of protein synthesis is simply a consequence of either the impairment of cell cycle progression or the induction of apoptosis, both of which are associated ... does not reverse the inhibition of protein synthesis. We conclude that the p53-regulated cleavages of eIF4GI and eIF4B, as well as the overall inhibitio...

Ngày tải lên: 23/03/2014, 18:20

... acti- vation of a cryptic splice site is a common cause of genetic disease. We recently reported the example of a deep intronic mutation c.31-279A>G in the NF1 gene of a patient with a severe form of ... exclusion. However, given that the m4 motif is immediately adjacent to the 5¢ splice site, it is very likely that this mutation is involved in recognition of this seque...

Ngày tải lên: 16/03/2014, 04:20

... finger is dispensable [28]. Another interesting example is provided by Pirh2, a p53-induced RING finger E3 ligase promoting ubiquitination and degrada- tion of p53; very recently, isoforms of Pirh2 ... examples of RING E3s, the activity of which critically depends on multiprotein complexes, including homo- or hetero-oligomers of RING finger proteins. Of note, interaction betwee...

Ngày tải lên: 06/03/2014, 09:22

... functionally an- notated protein sequences. The iProClass database is a central point for exploration of protein information, which provides summary descriptions of protein fam- ily, function ... repository of protein sequence and annotation created by joining Swiss-Prot, TrEMBL, and PSD. There are three knowledge components in UniProt: Swissprot, TrEMBL, and UniRef. Swis...

Ngày tải lên: 31/03/2014, 03:20

... and the other of residues from the SET-C and post-SET regions. Lysine 4 of histone H3 is inserted into a chan- nel, at the end of which is the AdoHcy binding site, which is composed of residues ... [35]. This analysis reveals that the iso- lated MLL1 SET domain is a relatively slow H3K4 monomethyltransferase, which is consistent with the predictions of the Phe ⁄ Tyr switch...

Ngày tải lên: 16/02/2014, 14:20

... reduction of the level of cell surface expres- sion of this mutated version of MT1-MMP. It is important to note that perturbation of the GRASP55 interaction with TGF-a [37], as well as p24 proteins [39], ... substrates. So far, it is unknown whether this mechanism is specific for the type I transmembrane MT-MMPs or whether it comprises a more general mechanism for furin-mediate...

Ngày tải lên: 18/02/2014, 04:20

... levels of secondary structure and disrupted tertiary structure [33,34]. Discussion According to the prion hypothesis, a key molecular event in the pathogenesis of prion diseases is the conversion of ... molecular event in prion diseases is the conversion of the cellular conformation of the prion protein (PrP C ) to an altered disease-associated form, generally denoted as scrap...

Ngày tải lên: 18/02/2014, 17:20

... members of the Ras family of small G proteins. The activity of Ras proteins is under tight control of several classes of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins. ... Furthermore, Ras-GRF1 is also heavily phosphorylated upon agon- ist activation of GPCRs, but the exact role of these phosphorylations is not fully understood. Protein kin- a...

Ngày tải lên: 19/02/2014, 18:20

... mobility of helix A of the protein. As Trp13 is located in the vicinity of the activation region AR2 of the protein [1], which is responsible for the activation of the second class of E. coli ... correlation time of Trp85 in apo-CRP of 20.5 ns indicates that this residue is immobilized within the N-terminal domain of the protein and exhibits motion characteristic...

Ngày tải lên: 20/02/2014, 23:20

... rate of protein synthesis, mutations and aberrant protein biogenesis, environmental (usually heat or oxidative) stress and heterologous protein production. Ageing is mostly known to induce protein ... production is by itself cause of toxicity for cells, independently of the nature of the recombinant protein. Energy depletion is the most immediate result and is due to...

Ngày tải lên: 06/03/2014, 00:20