Báo cáo khoa học: p53-induced inhibition of protein synthesis is independent of apoptosis pdf
Báo cáo khoa học: p53-induced inhibition of protein synthesis is independent of apoptosis pdf
... preparation).Thus it is unlikely that the regulation of protein synthesis is simply a consequence of either the impairment of cell cycleprogression or the induction of apoptosis, both of which areassociated ... does notreverse the inhibition of protein synthesis. We conclude thatthe p53-regulated cleavages of eIF4GI and eIF4B, as well asthe overall inhibition of protein synthesis, are caspase-inde-pendent ... some of these issues. Carefulcomparisons of the kinetics of translational down-regula-tion vs. the inhibition of cell cycle progression andinduction of apoptosis show that the effect of p53activation...
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Báo cáo khoa học: Polypyrimidine tract binding protein regulates alternative splicing of an aberrant pseudoexon in NF1 pdf
... acti-vation of a cryptic splice site is a common cause of genetic disease. We recently reported the example of adeep intronic mutation c.31-279A>G in the NF1 gene of a patient with a severe form of ... exclusion. However,given that the m4 motif is immediately adjacent to the5¢ splice site, it is very likely that this mutation is involved in recognition of this sequence either directlyor through ... Furthermore, involvement of positive regulatoryelements is suggested by the strong repression of pseudoexon inclusion in mutant m4. This effect couldbe due to disruption of a T-cell intracellular...
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Báo cáo khoa học: The SWI⁄SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt doc
... finger is dispensable [28]. Another interestingexample is provided by Pirh2, a p53-induced RINGfinger E3 ligase promoting ubiquitination and degrada-tion of p53; very recently, isoforms of Pirh2 ... examples of RING E3s, the activity of whichcritically depends on multiprotein complexes, includinghomo- or hetero-oligomers of RING finger proteins. Of note, interaction between RING finger proteinsP. ... the role of UnkemptRING finger remain uncertain. On the basis of theresults of a mutational analysis (Figs 3 and S1), itappears that the RING finger of exogenouslyexpressed Unkempt is not critically...
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Báo cáo khoa học: "Dynamically Generating a Protein Entity Dictionary Using Online Resources" pdf
... functionally an-notated protein sequences. The iProClass database is a central point for exploration of protein information, which provides summary descriptions of protein fam-ily, function ... repository of protein sequence and annotation created by joining Swiss-Prot, TrEMBL, and PSD. There are three knowledge components in UniProt: Swissprot, TrEMBL, and UniRef. Swissprot contains ... biology domain, it is critical to have a comprehensive biological entity dictionary that is always up-to-date. In this paper, we present a system that constructs a large protein entity dictionary,...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... and theother of residues from the SET-C and post-SETregions. Lysine 4 of histone H3 is inserted into a chan-nel, at the end of which is the AdoHcy binding site,which is composed of residues ... [35]. This analysis reveals that the iso-lated MLL1 SET domain is a relatively slow H3K4monomethyltransferase, which is consistent with thepredictions of the Phe ⁄ Tyr switch hypothesis [35].Substitution ... suggested on thebasis of this observation that proteins that interactwith the SET domain are required to induce the cor-rect conformation of the active site [26], which is con-sistent with the...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... reduction of the level of cell surface expres-sion of this mutated version of MT1-MMP. It is important to note that perturbation of the GRASP55interaction with TGF-a [37], as well as p24 proteins[39], ... substrates. So far, it is unknown whether thismechanism is specific for the type I transmembraneMT-MMPs or whether it comprises a more generalmechanism for furin-mediated activation of transmem-brane ... Quantification of MMP2was performed using imagequant tl software, version 7.0(GE Heathcare, Little Chalfont, UK).Statistical analysisStatistical analysis was performed using the graphpadprism, version...
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Tài liệu Báo cáo khoa học: The elusive intermediate on the folding pathway of the prion protein pptx
... levels of secondarystructure and disrupted tertiary structure [33,34].DiscussionAccording to the prion hypothesis, a key molecularevent in the pathogenesis of prion diseases is theconversion of ... molecular event in prion diseases is the conversion of the cellularconformation of the prion protein (PrPC) to an altered disease-associatedform, generally denoted as scrapie isoform (PrPSc). The ... as the scrapie isoform (PrPSc). Such diseases canbe sporadic, inherited or acquired by transmission.Sporadic Creutzfeldt–Jakob disease accounts for 85% of all cases of the disease; around...
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Tài liệu Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells pptx
... members of the Ras family of small G proteins.The activity of Ras proteins is under tight control of several classes of guanine nucleotide exchange factors(GEFs) and GTPase-activating proteins. ... Furthermore,Ras-GRF1 is also heavily phosphorylated upon agon-ist activation of GPCRs, but the exact role of thesephosphorylations is not fully understood. Protein kin-ase A (PKA) is one of probably ... kDa iso-form of Ras-GRF1 seems to be expressed at a higherlevel than the 140 kDa isoform. The serotonin-inducedincrease in phosphorylation of both isoforms wasreduced by the coexpression of...
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Tài liệu Báo cáo khoa học: Steady-state and time-resolved fluorescence studies of conformational changes induced by cyclic AMP and DNA binding to cyclic AMP receptor protein from Escherichia coli ppt
... mobility of helix A of the protein. As Trp13 is located in the vicinity of the activationregion AR2 of the protein [1], which is responsible for theactivation of the second class of E. coli ... correlation time of Trp85 in apo-CRP of 20.5 nsindicates that this residue is immobilized within theN-terminal domain of the protein and exhibits motioncharacteristic of the whole protein (within ... sites of the protein. The distance between the sulfur atom of Cys178 andthe C9–C10 bond of the indole ring of Trp85, derived fromthe crystal structure of CRP–(cAMP)2(PDB code 1G6N) is 18.9...
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Báo cáo khoa học: Concepts and tools to exploit the potential of bacterial inclusion bodies in protein science and biotechnology pdf
... rate of protein synthesis, mutations and aberrant protein biogenesis,environmental (usually heat or oxidative) stress andheterologous protein production.Ageing is mostly known to induce protein ... production is by itself cause of toxicity for cells, independently of the nature of therecombinant protein. Energy depletion is the mostimmediate result and is due to both the overproduced protein ... detailedanalysis of the mode of building and of the structure of aggregates can be useful to dissect pathways andbottlenecks in the folding of specific proteins, forexample those containing disulfide...
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Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ