Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx

... specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria Raka Ghosh, Sibani Chakraborty, Chandana Chakrabarti, Jiban Kanti Dattagupta and Sampa ... ervatamin -A and ervatamin-C The modes of binding of E-64 with ervatamin -A and ervatamin-C have been analyzed and compared with the structures of other comple...

Ngày tải lên: 18/02/2014, 16:20

... that is active against certain human pathogens such as Salmonella and Shigella [1], has an unusual lasso distinctive structure [2–4] and a dual mechanism of action. Microcin J25 inhibits transcription ... showing an initial rate of 7.02 4 light scattering ⁄ min · 10 4 . The initial rate of swelling increased as a function of MccJ25 concentra- tion (inset in Fig. 2) and b...

Ngày tải lên: 16/03/2014, 06:20

... time-dependent increase of the mRNA abun- dance in A7 r5 cells incubated at 1% oxygen for P4ha1 and P4ha2, starting around 4 h of hypoxia, the induction of P4ha2 mRNA being stronger than that of P4ha1 (Fig. ... 12 h of stimulation (Fig. 5A) . The stimu- latory effect of hypoxia and of deferoxamine on P4ha1 and P4ha2 mRNA and PDI mRNA was almost abrogated in Hep...

Ngày tải lên: 20/02/2014, 02:21

... spectro- metry. SDS/PAGE was carried out in separating gels containing 15% acrylamide. The following proteins were used as standards: phosphorylase B (97 kDa), bovine serum albu- min (67 kDa), ovalbumin (45 kDa), ... [23] and Beinert [24], respectively. Kinetic constants The catalytic activity of PHR was evaluated both in the presence and in the absence of PHI. K m and...

Ngày tải lên: 21/02/2014, 00:20

... by incubating the aldehyde in the presence of NADP + .As methylerythrose and DX, as well as the diacetate of methylerythrose and the triacetate of DX, have the same R f , the presence of DX triacetate ... concentrations of NADP + and MEP 5 ,the substrates of the reverse reaction, and of NADPH and DXP 3, the products of the reaction, on the tota...

Ngày tải lên: 21/02/2014, 03:20

... that there was no accumulation of TMR inside the cells and therefore that the potentials were eliminated. Table 1. Kinetic parameters for rhodamine and anthracycline derivatives. k a , the rate ... P-gp-associated efflux of rhodamine was calculated at the steady-state, taking into account the following points: (a) the diffusion (in ux and efflux) of rhodamine through...

Ngày tải lên: 08/03/2014, 08:20

... same slope was maintained (Fig. 2A C and Table S2). These results further suggest that these peptides enhance the dissociation of IN and its DNA substrate or inhibit the initial IN DNA binding, an observation ... mgÆL )1 purified IN. The reaction was initiated by the addition of 400 nm of the 3¢-processing substrate (5¢-[FAM]-ACTGCTAGAG ATTTTCCACGTGGAAAATCTCTAGCAGT-[DAB...

Ngày tải lên: 22/03/2014, 16:21

... Brucella, Rickettsia) and plants (Agrobacterium), symbionts (the N 2 -fixing rhizo- bia), many of the most abundant bacteria in the oceans (the Roseobacters and the SAR11 clade, includ- ing Pelagibacter) ... remaining after the addition of heme (Fig. 4A) . A simple analysis of absorbance changes indicated that oligomerization of H4 6A and H6 6A Irr Rl in the p...

Ngày tải lên: 28/03/2014, 22:21

... domains (a b-domain for the N-terminal cluster and an a- domain for the C-terminal cluster). In the absence of metals, apo-thionein (apo-T) is predominantly unstruc- tured and only upon metal ... cysteines and the absence of His and aromatic amino acids. MT3 contains 68 amino acids with 70% sequence identity to the MT1 and MT2 (MT1 ⁄ 2) isoforms. The MT3 sequenc...

Ngày tải lên: 16/02/2014, 15:20

... catalytic subunit has similar light and heavy chains to trocarin D. The non-enzy- matic subunit has a heavy chain (consisting of A1 and A2 domains) and a light chain (consisting of A3 , C1 and ... Typical ADAMs are type-1 integral membrane proteins and have an epidermal- growth-factor-like domain, a transmembrane domain and a cytoplasmic domain, in addition to...

Ngày tải lên: 14/03/2014, 22:20