Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf

... move away from the heme and the B-helix moves closer to the heme in the WT metHbthanintherWTmetHbH 2 O crystal structure, with the result that the ligated water is lost in the latter complex [16,17]. Prior ... position E7 as the source of the H- bond to ligand on the basis of a partial sequence, which had indicated a Tyr on the distal E-helix. The similari...

Ngày tải lên: 23/03/2014, 17:22

... Kunitz domains, of which only the N-terminal Kunitz domain-1 (KD1) inhibits enzymatic activity. In the structure of the KD1–HGFA complex, the inhibitor interacts with the active site region by ... two nonstandard conformations. Herein, we use the con- formation seen in the complex of HGFA with Kunitz domain-1 (KD1) as the representative of the standard confo...

Ngày tải lên: 15/03/2014, 11:20

... of the chaperone with the second domain seems unlikely also in the case of ATP7B. The selectiv- ity, if any, for the interaction of one of the six metal- binding domains with the chaperone should ... what observed for MNK2 [21]. The behaviour observed for the interaction of HAH1 with MNK2 and MNK5 is somewhat different from that observed for the yeast...

Ngày tải lên: 30/03/2014, 15:20

... independently of the presence of AREs (Fig. 6B, lanes 2 and 5). It is possible that in the region located before the AREs, consisting of 343 bp of the 3¢ UTR of the IL-1b transcript, there is a putative ... prevented the increase in the MCPIP mRNA level for both forms (Fig. 5A, lanes 5 and 6, upper bands). Moreover, in a co-transfection study with the IL-1b-e...

Ngày tải lên: 18/02/2014, 14:20

... and inserted into the lower part of b-shee t A, which explains the increased stability. However, this helix must be readily displaced by the reactive loop of another molecule t o form t he chains ... similar to that of the polymeric conformation in which b-sheet A is filled with the reactive loop of another neuroserpin molecule. Moreover th e emission maxima of the nati...

Ngày tải lên: 07/03/2014, 16:20

... larger volume than the hula-twist (HT) or the phi OBF. However both the HT and phi OBF processes dis- place the same volume. A hula-twisting motion of the excited state chromophore is not necessarily ... the open state in the absence of a ligand. Binding of the ligand trig- gers the domain closure during which the two domains rotate by about 30° respect to each oth...

Ngày tải lên: 23/03/2014, 15:20

... residues D2¢,E3¢, R17¢ and T18¢ which have the largest devi- ations from the most highly populated regions of the Ramachandran plot, and which contribute to the proportion of residues in the disallowed ... at the site of the two prolyl residues, and fold back towards the hydrophilic side of the helix. In DPC-d 38 , the helix is more elongated despite simi...

Ngày tải lên: 19/02/2014, 07:20

... above. • Out of these 30 baseline reports, we have se- lected the 10 reports which have the highest sentence overlap with the manual summaries. The second step increases the quality of the base- lines, ... six months afterwards, they would be exam- ined from each of the eight topics. The only docu- mentation allowed during the exam would be the re- ports generated...

Ngày tải lên: 20/02/2014, 15:20

... order. The analysis of the model ensemble indicates, a possible hydrogen bond between the hydrogen of OH9 (H O 9) and the oxygen of OH7 (O H 7) which can contribute to the stabilization of the C7–C9 ... 4D, left). However, for the C1–C7 segment, the two hydroxyl groups on C3 and C5 are, respectively, hydrogen bonded with the CO groups of C1 and C7 in th...

Ngày tải lên: 21/02/2014, 03:20

... every candidate. Finally, we pick the one, which has the most votes, as the final result for the piece. The difference in these three voting methods is that we make the decisions in different ranges: ... to resolve the special problems of Chinese chunking by extending the chunk tags. The experimental results showed that the SVMs model was superior to the other three m...

Ngày tải lên: 08/03/2014, 02:21