Báo cáo khoa học: N-Glycan structures of squid rhodopsin Existence of the a1–3 and a1–6 difucosylated innermost GlcNAc residue in a molluscan glycoprotein pot

... N-Glycan structures of squid rhodopsin Existence of the a1 –3 and a1 –6 difucosylated innermost GlcNAc residue in a molluscan glycoprotein Noriko Takahashi 1 , Katsuyoshi Masuda 2 , Kenji Hiraki 2 , ... two potential glycosylation sites, Asn2 and Asn15, predominantly express the structure Mana1–6 (GlcNAc b1–2Mana1–3)Manb1–4GlcNAcb1– 4GlcNAc. In...

Ngày tải lên: 23/03/2014, 17:22

... [32]. Together, the M and C domains of human eRF1, in the absence of the N domain, are able to bind to the mammalian ribosome and induce GTPase activity of eRF3 in the presence of GTP [33]. The previously ... Plot of the number and distribution of NOEs against the amino acid sequence used in structure calculation of the M domain of human eRF1. Fig...

Ngày tải lên: 07/03/2014, 05:20

... suggest that in P19 cells (a pluripotential teratocar- cinoma line) the failure to activate the IFN-b promoter was not due to the absence of the pathway leading to activation of IRF-3 and IRF-7. The ... occurrence of a n infection to other cells, allowing coordination of the a daptive response a t the organismal level. The IFN-b gene plays a crucial role...

Ngày tải lên: 23/03/2014, 13:20

... 84–88, 94–95, and 102–104 (Fig. 1B). A single chain of TtAKb contains two ACT domains, ACT1 (N-termi- nal domain) and ACT2 (C-terminal domain) domains. The ACT domain organization of TtAKb-Thr is similar ... chain. (C) Vacant Thr-binding site in TtAKb- free. Residues in blue are in the E chain, and residues in orange are in the F chain. (D) Structure-based sequence...

Ngày tải lên: 18/02/2014, 08:20

... 5500 A ˚ 2 , TbPDH has a larger interface surface area of 6200 A ˚ 2 . The cofactor-binding site The cofactor binds on the periphery of domain I (Figs 3B,4) with the adenine ribose approaching the b1 a1 ... side by a set of four helices (a9 – a1 0 a1 6 a1 7). Helices a1 2 a1 3 a1 4 a2 0 are placed at the dimer interface. Domain III, residues 434–469, is assigned as...

Ngày tải lên: 19/02/2014, 05:20

... Technical University of Lodz, Poland Introduction Bifidobacteria are found in human and animal gastro- intestinal tracts, as well as in the oral cavity and the vagina [1]. They are among the first bacteria ... strand of the next blade by an interblade loop. This domain contains one additional structural element, an a- helix, sticking to the surface of the cylinder in...

Ngày tải lên: 06/03/2014, 00:21

... and g positions in HR1 and the a and d positions in HR2, are labeled. Residues that are important in the end deep groove in HR1 and HR2 are framed and labeled with a blue triangle and red star. ... typical characteristics of NiV and HeV F proteins as members of the Paramyxoviridae family, and provide a struc- tural basis to explain the inhibitory effe...

Ngày tải lên: 08/03/2014, 08:20

... company to awarded, treating awarded as the main verb. In the case where awarded must be treated as the beginning cf a reduced relative, Warren found that the duration of the final syllable of ... capable of transmitting a request and signaling a binary reponse, either blocking or allowing the application of the relevant strategy according to the presen...

Ngày tải lên: 08/03/2014, 18:20

... exception betweenAsp16andArg36,whichisseeninthe1. 6A ˚ model. The amino acids are shaded in red, gree n and blue for acidic, neutral an d basic polar residues, and in yellow for prolines and glycines. In (C) the ... reas are shown in white. In (B) the conserved regions that interact with Ubc9 and Ulp1 are highlighted andcolouredinorange,cyanandmagenta,as in Fig. 1....

Ngày tải lên: 16/03/2014, 18:20

... indinavir, of 3.8 A ˚ .In PR V8 2A , the change in the position of the main chain atoms placed the Cb atom of Ala82 within reasonable van der Waals distance of indinavir (4.1 A ˚ ), resulting in a ... hydrogen bond interactions with the amide and OD2 of Asp29¢ ,and interacted via water OB with the carbonyl oxygen of Gly27, the OD1 of Asp29¢ and t...

Ngày tải lên: 23/03/2014, 12:20