... or a combination of both (Fig. 1). In the following, such in vivo models are described which address certain aspects of membrane topology, folding,intracellular targeting and trafficking of PrP. ... in mediating the neurodegeneration process is increasingfor PrPC. Evidence for this was found in neurograftingapproaches [6], in conditional prion protein (PrP)knockout studies [7] and in ... important domain for basolateral sort-ing of PrPC. Moreover, Dpl, containing either thewhole N-terminal domain of PrPCor the HD only,was sorted basolaterally, indicating that this domainacts...