Báo cáo khoa học: Advances in functional protein microarray technology Paul Bertone and Michael Snyder doc

... time and complexity involved with the cloning and purification of individual proteins as a prerequisite to constructing functional protein microarrays. In terms of assessing protein protein interactions, protein ... preparing hun- dreds or thousands of individual protein samples, the proteins must remain active during the manufacture and probing of microarrays. This entails k...

Ngày tải lên: 23/03/2014, 15:21

... blocks in the N-terminus and histone fold of Cid may mediate essential protein protein interac- tions for recruitment of other centromeric proteins, neutralize phosphates in linker DNA and further ... containing poly(ADP-ribose) polymerase activity and other single strand RNA viral proteins. They show structural similarity to the DNA binding domain of leucine aminopeptidases, sugg...

Ngày tải lên: 20/02/2014, 02:22

... regularization penalty by decreasing λ (Steps 1.6 and 1.7) and continue training. In this way, instead of choosing the best λ heuristically, we can optimize it during a single training run (Turian & ... set as training progressed. Even though the baseline training made progress more quickly than the kitchen sink, the kitchen sink’s F 1 surpassed the baseline’s F 1 early in trainin...

Ngày tải lên: 08/03/2014, 02:21

... Towards Functional Logic Grammars. In Dahl, V. and Saint-Dizier P. (Ed.), Natural Language Programming and Logic Programming, II. Amsterdam: North Holland. Elhadad, Michael. (1988). The FUF Functional ... INTRODUCTION Unification-based formalisms are increasingly used in linguistic theories (Shieber, 1986) and com- putational linguistics. In particular, one type of u...

Ngày tải lên: 24/03/2014, 02:20

... translations for preliminary tests and advised on prepa- ration of the final text, and to D. B. Robinson, Jr., L. Rosier, and B. J. Kinsberg for their contributions to selection of passages and preparation ... but with a feeling of uncertainty as to whether it was the intended interpretation. Subjects in the first study judged the sentences in paragraphs. It was intended as...

Ngày tải lên: 19/02/2014, 19:20

... The PAG gene prod- uct, a stress-induced protein with antioxidant proper- ties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev 11, 2456–2467. 91 ... the protein that inhibits the intrinsic tyrosine kinase activity of the oncoprotein c-Abl [90]. Later, the study of the cytosolic yeast 2-Cys Prxs, cPrx1 and cPrx2, was extremely...

Ngày tải lên: 07/03/2014, 00:20

... substrates, in particular at the acceptor site, including deoxycytidine kinase, human mitochondria thymidine kinase 2 and herpes thymidine kinase 1 and 2 [27–29]. Only human deoxycyti- dine kinase ... Biosciences) in Tris/HCl 50 m M , pH 7.5 containing 200 m M KCl and 1 m M dithiothreitol, using bovine albumin, ovalbumin and chymotrypsinogen as markers. The elution volume of UMP-C...

Ngày tải lên: 08/03/2014, 02:20

... knowledge for processing the semantics of words and documents. However, maintaining a thesaurus so that it sufficiently covers the lexicon of novel text data requires a lot of time and effort, which ... it first determines a set of k nearest neigh- bors according to the similarity metric and as- Learning Accuracy (Hahn and Schattinger 1998) as an evaluation measure is described in...

Ngày tải lên: 08/03/2014, 21:20

... Graehl, Kevin Knight, Daniel Marcu, Steve DeNeefe, Wei Wang, and Ignacio Thayer. 2006. Scalable inference and training of context-rich syntactic translation models. In Proceed- ings of the 21st International ... pair (using morphological informa- tion) showed that it improved the results in terms of BLEU (Papineni et al., 2001) and NIST (Dod- dington, 2002) scores, as shown in Tab...

Ngày tải lên: 23/03/2014, 16:20

... recognition and phosphatase recruitment for some STATs [2–5]. The N-domain is followed by a coiled-coil domain implicated in protein protein interactions [6], a DNA binding domain [7], a linker domain ... role of STAT proteins in cytokine signaling. Upon binding of extracellular ligands such as interferons or interleukines to their cognate receptors, re ceptor-asso ciated Janus kinas...

Ngày tải lên: 30/03/2014, 15:20