Báo cáo khoa học: Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4 doc
Báo cáo khoa học: Crystal structure determination and inhibition studies of a novel xylanase and a-amylase inhibitor protein (XAIP) from Scadoxus multiflorus pot
... pres- ence of two consecutive Pro residues at positions 103 and 104 alters the path of the protein chain, resulting in the formation of a loop that protrudes away from the protein surface into the solvent. ... solvent. There is yet another interesting feature of the XAIP structure which is related to the conformation of loop b3–a3. This loop extends via the cen...
Ngày tải lên: 29/03/2014, 09:20
Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... Breit SN et al. (2005) Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4. FEBS J 272, 4996–5007. 5 Singh H & Ashley RH (2007) CLIC4 (p64H1) and its putative ... groups. The one exception to this is the location of the amide group of Lys204 at P3, where there is a break in the main-chain density at the...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... conformation around the active site of ApeSOD is independent of the presence of a metal cofactor. Figure 3D shows the superimposition of the active site structures of apo, Mn-bound and Fe-bound Ape- SODs. The ... bacterium Thermus thermophilus, we evaluate the relationship between electrostatic interaction and the protein s stability in an organic medium. Results Pro...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc
... asymmetric unit of its tetragonal unit cell. The con- formation of the two molecules is similar with a rmsd of 0.5 A ˚ for the superposition of 394 C a atoms [17]. The globular fold is composed of two ... Thus, the differences between wild-type and mutant structure are in the same range as the dif- ferences between the two molecules of the asymmetric unit of...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
... inspection, however, reveals that the most similar regions of these proteinases medi- ate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of ... according to the residue in the mid- point of the respective loop, as shown in Fig. 2. To the east of the active site the 37- and 60-loops border the S2¢ pocke...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc
... addition, it binds acetate which is the product of a deacetylation reaction. (c) The protein forms stable homohexamers both in the crystal form and in solution. Thus, the functional state of the ... in the purification or crystallization protocols, we conclude that the metal must be intrinsically contained in the protein. The structure of the active site is i...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... in the activation process [29]. These conformational transitions are accompanied by large-scalechangesintherelativeorientationofthedimers in the tetramer. In the three-dimensional structure of ZmPDC,theactivesiteloopsarewellorderedand observed ... residues of this loop are invisible in the structure of IPDC. None of the insertions/deletions occur near the active site,...
Ngày tải lên: 20/02/2014, 11:20
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... adjusted to the pH of the reaction mixture before addition to the mixture. One Fig. 8. Tris in the TG structure. The F o -F c electron density in the map of the TG structure is contoured at the +2.4 ... in the G and TG struc- tures. The electron density of l-glutamate became more pronounced upon the addition of Tris. The location and orientation of l-gluta...
Ngày tải lên: 06/03/2014, 09:22
Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases pptx
... part, and (b) the variability of the angle of approach of the inhibitor relative to the catalytic cleft of the enzyme. The latter factor may reflect not so much the geometry of the catalytic site ... superposition of the cruzipain model on the papain portion of the complex described in the present study. Conclusions The chagasin–papain complex presented...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima docx
... nonarchaeal IMPases. The superposition of the second subunit of the MJ0109 structure (1G0H) after superposition of the first subunit requires a rotation of 15° along the longest axis of the dimer in one direction, ... 1. Schematic of the transformation of TM1415 into the eukaryotic FBPase. The transformation requires 25° rotation of the dimers around...
Ngày tải lên: 16/03/2014, 11:20