Báo cáo khoa học: The astacin protein family in Caenorhabditis elegans docx

... protease domains,covering the region from Ala-1 to Leu-200 in the prototype crayﬁsh astacin, from the C. elegans astacinsand selected other astacin family members were alignedusingCLUSTAL[32] ... named aftertheir occurrence in complement components C1r/C1s,embryonic sea urchin protein Uegf, and BMP-1 [62].These domains may be involved in calcium-binding and protein- protein or enzyme–substrate ... prototype for the astacins.A second member of the astacin protein family wasidentiﬁed when Wang et al. and Wozney et al. (1988) studied the human bone-inducing factor BMP-1, into which adomainwithhighresemblancetocrayﬁshastacinisinserted[12,13]....

Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... startingpoints for invasion. The concerted process of openingof the initial double strand and the annealing of the new duplex ﬁnally results in either the replacement of the original strand or the ... repulsive interactionswithin the RNA molecule. The protein therebysmooths the folding energy landscape. The direction of the RNA folding reaction (either annealing or dis-placement) is then no ... summarize the properties of the three protein classes, with the main focus being on RNAchaperones and annealer proteins.Speciﬁcally binding proteinsA speciﬁc protein cofactor binds to its RNA targetthrough...

Tài liệu Báo cáo khoa học: "The Nature of Affixing in Written English" docx

... consonantal doubling rules in the inflection of English verbs C. The determination of word-breaking rules as used in end-of -the- line practices in type composition D. The determination of parts-of-speech ... have the property that the internal-consonant string is an ad- missible initial-consonant string. The words in Class III have the mirror image property that the internal-con- sonant string ... -LING -WARD EX- UN- The definitions P1 and S1 can be extended to include the words belonging to Class II and Class III, and these will give the vowel-ending prefixes and the vowel-beginning...

Báo cáo khoa học: "The Use of Statistics in Language Research" docx

... extracted by the methods of the linguist than by those of the statistician. The indeterminacy which does exist in lan- guage is the indeterminacy which arises from the mapping of a continuous ... Compression In large measure the coding problems arising in MT and in library work are the same as those occurring in other branches of communi- cation engineering. The need for code compres- ... urgently in MT, be- cause of the great bulk of the material to be stored, but the mathematical problems it pre- sents are the same as in other fields, except where, as in the use of thesaurus...

Báo cáo khoa học: The role of DYRK1A in neurodegenerative diseases docx

... (NFTs) in the brains ofpeople with DS ⁄ AD than in the brains of people withsporadic AD (Fig. 2) [19]. DYRK1A phosphorylatestau protein at the sites that are phosphorylated in AD. In NFTs, tau protein ... DYRK1Aphosphorylation of tau protein at 11 sites [20,22,43]; the DYRK1A-stimulated, several-fold increase in the rate of tau protein phosphorylation by GSK-3b[20,43]; the several-fold increase in the number ofDYRK1A-positive ... H, Noda M & Kinoshita M (2003)Association of the cytoskeletal GTP-binding protein Sept4 ⁄ H5 with cytoplasmic inclusions found in Parkin-son’s disease and other synucleinopathies. J Biol...

Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx

... alone. The kinase-deﬁcient mutant,OXI1K45R, in which the lysine residue of the ATP bind-ing domain is mutated to arginine, still interacted withPTI1-4. These data indicate that the kinase ... of the input was loaded on to the geland represents the amount of HIS-tagged proteins used for the assay. The in vitro binding assays were repeated twice usingrecombinant proteins prepared independently ... protein kinase; MAPKK, mitogen-activated protein kinase kinase; MBP, myelin basic protein; OXI1, oxidativesignal-inducible 1; PDK1, 3-phosphoinositide-dependent kinase 1; PTI1, Pto-interacting...

Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: intersubunit interactions during virus assembly doc

... with the N-terminal domain, MA, associated with the innerlayer of the viral membrane, and the remainingdomains forming the innermost protein layers accor-ding to their positions in Gag: MA, CA-NTD,CA-CTD, ... SpainIntroductionDuring HIV-1 morphogenesis [1,2], the capsid protein (CA; or p24) participates in two distinct assemblyevents. The ﬁrst occurs inside the cell and involves the Gag polyprotein, ... independentproteins and peptides leads to the disassembly of the spherical capsid inside the virion. Some of the foldeddomains of Gag are then able to reassemble as inde-pendent proteins. The matrix protein...

Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: designing inhibitors of capsid assembly ppt

... of both the CAI peptide and a-helix 9of CTD during formation of the peptide– protein and protein protein complexes.These NMR experiments also allowed the determina-tion of the CTD binding site. ... 6110–6117 ª 2009 The Author Journal compilation ª 2009 FEBSGag polyprotein, yields the matrix protein (MA), the capsid protein (CA), the nucleocapsid protein (NC) and p6 proteins, as well as ... in red, the b-sheets in yellow and the loops in green. The circle at the bottom of the ﬁgureindicates the region where the binding ofCAP-1 occurs. The ﬁgures were producedusingPYMOL (http://www.pymol.org)...

Tài liệu Báo cáo khoa học: The lipid ⁄ protein interface as xenobiotic target site Kinetic analysis of tadpole narcosis ppt

... employing microscopic lipid-binding con-stants has previously been taken to explain the enhancement of agonistbinding to the nicotinic acetylcholine receptor by general anaesthetics in terms of the ... simulate the unknownnarcotic receptor(s) of tadpoles, all other parameterscharacterizing the nAChR lipid ⁄ protein interfaceremaining constant. The initial analysis assumes a uni-form increase in ... of the nAChR over all binding sites: m ¼ 40 (solid line), or over part of the binding sites: m ¼ 10 (dotted line), and m ¼ 4 (dashed line). The data points for enhancement of agonist binding...

Tài liệu Báo cáo khoa học: The sensor protein KdpD inserts into the Escherichia coli membrane independent of the Sec translocase and YidC doc

... multispan-ning membrane proteins, we have investigated the mechan-ism of how the sensor kinase protein KdpD inserts into the membrane. We found that KdpD inserts into the membraneindependently of the ... KdpD-N. The protein was not accessible to the externally added proteinase K,indicating that it remains in the cytoplasm. Intriguingly, the formation of the dimeric form was also blocked. In contrast, the ... was then used to monitor the location of the epitope-tagged region with respect to the KdpD protein in the membrane. The KdpD protein with the epitope tags wasreadily digested by proteinase K in...

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