Báo cáo khoa học: Solution structure of human proinsulin C-peptide ppt

... C-peptide in water. C. E. Munte et al. Solution structure of C-peptide FEBS Journal 272 (2005) 4284–4293 ª 2005 FEBS 4293 Solution structure of human proinsulin C-peptide Claudia Elisabeth Munte 1 , ... structure of proinsulin C-peptide in aqueous solution and in the presence of lipid vesicles. Cell Mol Life Sci 57, 337–342. 27 Xie L & Tsou C-L (1993) Com...

Ngày tải lên: 23/03/2014, 15:20

... coordinate comparison of our solution structure of human PDI-bb¢ and the crys- tal structure of the I289A mutant of the human PDI- b¢x fragment [16] showed differences with an rmsd of 2.6 A ˚ for 116 ... the crystal structure of yeast PDI-b¢ (red, Protein Data Bank entry code 2B5E). (C) Superimposition of the solution structure of human PDI-b¢ (blue) with the...

Ngày tải lên: 16/03/2014, 04:20

... seven cycles of NOE assignment and structure calculation by cyana ⁄ candid, a set of 20 structures that satisfy the experimental constraints was obtained. The Solution structure of hirsutellin ... mecha- nism of transphosphorylation, which implies the A B Fig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-site residues of the 20 conformer...

Ngày tải lên: 18/02/2014, 08:20

... Schibli,D.,Hunter,H.N.,Aseyev,V.,Starner,T.D.,Wiencek, J.M.,McCray,P.B.,Tack,B.F.&Vogel,H.J.(2002)Thesolution structures of human b-defensins lead to a better understanding of the potent bactericidal activity of HBD-3 against Staphilococcus. J. Biol. ... (2001) The NMR structure of human b-defensin-2 reveals a novel a-helical segment. Biochemistry 40, 3810–3816. 54. Hoover,...

Ngày tải lên: 20/02/2014, 11:20

... domain, MAR-BD) encompasses residues 71–195 of human MeCP2 [corresponding to residues 72–196 in chicken (c)MeCP2] [15]. The solution structure of the MBD of rat (r)MeCP2 has recently been determined ... contacting the DNA backbone. The solution structure of the MBD of MBD1 shows high similarity to that of MeCP2 except for the C-terminus [18]. At the C-terminus of the M...

Ngày tải lên: 21/02/2014, 00:20

... corrected solution structure is in a good agree- ment with the crystal structure of human CNPase cata- lytic domain (rmsd of 2.3 A ˚ over 205 residues). Sequence alignment of the catalytic domain of RICH ... The secondary structure elements refer to the solution structure of goldfish RICH. The con- served catalytic H-X-(T ⁄ S)-X motifs are shown in bold. G. Kozlov et al...

Ngày tải lên: 07/03/2014, 10:20

... chain of Fig. 3. Structure ensemble of HPr(I14A). The average structure of the 10 lowest- energy structures out of 300 calculated with CNS is shown. TheradiusofthesplinereflectstheRMSDvaluesoftheC a atom positions. ... deviations of the chemical shifts of the amide nitrogen and p roton nuclei. Results Determination of the three-dimensional structure of HPr(I14A) To allow...

Ngày tải lên: 07/03/2014, 16:20

... 4. Stereo plot of th e families of conv erged structures of is o d(GGGGCCCC) 2 . (A) B FI (39 structures), (B) BFII (20 structures), (C) AFI (85 structures), a nd (D) AFII ( 15 structures). Table ... model AFI of 2¢,5¢ d(G 4 C 4 ), possesses composite features of both A and BDNA. In view of these, it is perhaps appropriate to regard the structure of iso d(G 4 C 4 ) as a hybrid...

Ngày tải lên: 16/03/2014, 18:20

... of the L68Q mutation for the stability of monomeric HCC could only be inferred from the structures of 3D domain- swapped dimers of HCC. The present structure pro- vides the first possibility of ... domain-swapped dimer of HCC shows unaltered inhibition of legumain, whereas it is incapable of papain binding, because of the absence of the L1 ele- ment of the recognition s...

Ngày tải lên: 22/03/2014, 21:20

... Determining the deviation of the generated structure with a reduced number of NOEs from the published MT1 structure provides a measure of accuracy shown in Fig. 4B. As can be seen, the structure of MT1 without ... and accuracy of the generated structure. Figure 4A shows the r.m.s.d. of 10 sets of s tructures, generated as described in Materials and methods, to the average...

Ngày tải lên: 23/03/2014, 13:20