... minimal.Morphological evidence of the antiapoptoticeffect of HSSAs shown in Fig. 2A,B, the treatment of cells with50 lm CCCP induced profound changes in the nuclearmorphology of hepatoma cells, with ... decreasing the activity of caspase-3 in the three cell lines.Effect of HSS knockdown on CCCP-inducedapoptosisTo further elucidate the functional role of HSS inCCCP-induced apoptosis, the expression ... opening of the nonselective, highly conductive PTP in the mitochon-drial IM [39]. The exact molecular composition of the PTP remains unclear. When MPT occurs, MPcollapses, leading to the failure of...