Báo cáo khoa học: N1 – IUBMB 50th Anniversary Symposium: Protein Structure and Function potx

... deluge of newspaper articles on ‘The brave new Abstracts 22 N1 – IUBMB 50th Anniversary Symposium: Protein Structure and Function N1- 001 Molecular biology of mammalian prions A. Aguzzi Department ... box motif, a central SPRY domain and a variable N-terminal region. The SPRY domain is common to many proteins with diverse functions and is involved in protein prote...

Ngày tải lên: 23/03/2014, 15:20

... m M AAD and 2.2 lM KATII, with the following concentrations of inhibitors: 1 m M ESBA (a 9–1 0), 100 lM ESBA (b 9–1 0), 200 lM CSA (c 9–1 0), 20 lM CSA (d 9–1 0), 5 mM BCA (e 9–1 0), 500 lM BCA (f 9–1 0), ... m M 3-NPA (a1 1–1 2), 5 mM 3-NPA (b1 1–1 2), 2 mM OPS (c1 1–1 2), and 200 l M OPS (D1 1–1 2). (B) Transamination activity of KATII in the presence of either AAD,...

Ngày tải lên: 06/03/2014, 00:21

... lines and j rows with binary values. The value zij = 1 (zij = 0) means that the word i influences (not) the word j. In figure 1 every link stands for zij = l. The models 1, 2 and 2 ~ and ... from TL to SL and vice versa. If we use P(e[d) or P(dle ) we receive different WAs z~ d and z d-e. Intuitively the relation between the words of the sentences should be symmetric and...

Ngày tải lên: 08/03/2014, 05:21

... numbering, i.e. ‘38-loop’, and the corresponding Perona and Craik [6] nomenclature, i.e. ‘Loop-A’) and substrate subsites (S1–S4). The catalytic triad Asp102–His57–Ser195 is indicated. (C) Conforma- tional ... Journal 277 (2010) 221 5–2 222 ª 2010 The Authors Journal compilation ª 2010 FEBS cleavage site of pro-HGF is KQLR-VVNG(49 1–4 98) (P4–P4¢) and that of pro-MSP is SKLR-VVNG(...

Ngày tải lên: 15/03/2014, 11:20

... illustrating the E- and F-helix N i –N i+1 connections (solid lines and arrows), the F-helix a i – N i+1 connections (dashed lines), and the dipolar contacts between Tyr32(B10), Tyr66(E7) and Phe46(CD1). Table ... as standard in a diamagnetic protein [48], with the remainder of the target residues assigned by detection of NOESY residue–heme and interresidue cross-peaks solely...

Ngày tải lên: 23/03/2014, 17:22

... NMR-derived structure showed the presence of two helical regions: PLLILGS( 3–9 ) and IQAIHDAQ(1 7–2 4), with residues LLMTPPV(1 0–1 6) forming a turn. The structure of the central LMTPPV(1 1–1 6) region ... of X - PLOR [24]. The ponera- toxin structure was deposited in the Protein Data Bank (http://www.rcsb.org), accession code PDB1G92. Chemical Ó FEBS 2004 Structure and...

Ngày tải lên: 30/03/2014, 13:20

... Gene structure, multiple alternative splicing, and expression in gonads of zebrafish Dmrt1. Biochem Biophys Res Commun 330, 95 0–9 57. 25 Johnsen H, Seppola M, Torgersen JS, Delghandi M & Andersen ... post- translational and functional regulations of the dmrt1a ⁄ dmrt1bY gene pair in medaka. 1010 FEBS Journal 278 (2011) 101 0–1 019 ª 2011 The Authors Journal compilation ª 2011 FEB...

Ngày tải lên: 14/02/2014, 19:20

... 0.05 a 6 1. 0–1 .2 PGK–5aa–cerulean GAPDH–5aa–citrine 42.2 1.19 ± 0.07 a 58.8 3.27 ± 0.14 a 6 0. 8–1 .0 PGK–7aa–cerulean 43.4 1.32 ± 0.05 c 56.6 3.46 ± 0.09 c 6 1. 0–1 .1 PGK–7aa–cerulean GAPDH–7aa–citrine ... for PGK); and (C) 10 amino acids (TDPGAGPVAT for GAPDH; MDPGAGPVAT for PGK). P5C, PGK– 5aa–cerulean; G5Y, GAPDH–5aa–citrine; P7C, PGK–7aa–cerulean; G7Y, GAPDH– 7aa–citrine; P10C...

Ngày tải lên: 16/02/2014, 09:20

... of AF4 con- fers binding to ENL and ⁄ or AF9 (which in turn binds to AF10 and DOT1L). Therefore, MLL–AF4, MLL– AF9, MLL–ENL and MLL–AF10 fusion proteins are all functionally equivalent as they ... MLL–AF4. Short-term protein expres- sion of MLL–AF4 in a doxycycline-dependent manner resulted in the ectopic activation of HoxA7 and HoxA10 (and 560 other genes), whereas the reciprocal...

Ngày tải lên: 16/02/2014, 14:20

... fitted with the heterogeneous ligand interaction Table 1. NMR and refinement statistics for NarG( 1–1 5) and NarG( 1–2 8) structures. NarG( 1–1 5) NarG( 1–2 8) NMR distance and dihedral constraints Total ... lowest energy conformers of the solution structure of (A) NarG( 1–1 5) and (B) NarG( 1–2 8). A B Fig. 2. (A) Sequences of NarG( 1–1 5) (left) and NarG( 1–2 8) (r...

Ngày tải lên: 16/02/2014, 14:20