... keratin-associated proteins via disulfide bindings [6, 7]. All the keratin proteins are composed of an N-terminal rod domain, a central rod domain, and a C-terminal tail domain. Importantly, the N-terminal and ... date result in a deleterious amino acid substitution within either the HIM or the HTM of the rod domain. These hair keratins are predominantly expressed in the keratinizing zone of the hair ... Then, TACE induced ectodomain shedding of TGF-α, which resulted in transactivation of EGFR (Figure 18) [101]. Notably, in the HF of the Liph-KO mice, the expression of cleaved TGF-α, tyrosine-phosphorylated...