... A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence Anna Henricson, Lukas Ka¨ll and Erik L. L. SonnhammerCenter for Genomics and Bioinformatics, ... Chiesa R & Harris DA (1997) Evidence for a six -transmembrane domain structure of presenilin 1.J Biol Chem 272, 12047–12051.24 Nakai T, Yamasaki A, Sakaguchi M, Kosaka K, Miha-ra K, Amaya ... experimental data that supportHRX as a TM region. At the same time, there are experimental studies that contradict HRX as a TMregion. Only the topology model by Nakai et al. sup-ports HRX as a TM...