Báo cáo khoa học: A strategy for the generation of specific human antibodies by directed evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom docx

... evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom Lidia Rian ˜ o-Umbarila, Victor Rivelino Jua ´ rez-Gonza ´ lez, ... immunogenic characteristics and clearance properties [9]. Display of antibody fragment libraries on the surface of filamen- tous phages has replaced...

Ngày tải lên: 23/03/2014, 13:20

... applications: the design of novel specific pro-drug and mutant combi- nations for gene therapy, the development of species- specific antiviral and antibacterial nucleoside analog based drugs, and ... based on deoxyribonucleoside kinases is a method of therapeutic intervention to treat various cancers and also has applications in transplantation technology. The basis...

Ngày tải lên: 30/03/2014, 20:20

... may be represented by associating questions to each node and the possible answers to the arcs coming from a node ; the leaves of the tree bear the name of the code and an example. A language ... commands. The main functions of ATLAS are the following : - Editing and updating of indexing charts : compi- lation of an external form of the chart,...

Ngày tải lên: 17/03/2014, 19:21

... is one of the human parasites and there is a possibility that the prod- ucts prepared using the GST tag react with the human serum and cause objective background. On the other hand, 4AaCter 696–851 ... Sakamoto 1 , Takaaki Yamashita 1 , Motoaki Uchida 1 , Kenji Matsushima 1 , Yohko Kashino 1 and Hiroshi Sakai 1 1 Graduate School of Natural Science and Technology,...

Ngày tải lên: 29/03/2014, 09:20

... medical opinions concur that there is no meaningful chance of reanimation [8]. Some reasons why this occurs are as follows: 1. Physicians tell surrogates that they can make any decision they want ... suspended animation; they are not alive in the sense the we enjoy life but neither are they able to die as long as nutrition, hydration, ventilation, and perfusion are assured. In man...

Ngày tải lên: 25/10/2012, 10:45

... tail of the pancreas. For tumors of SPT located in the neck and body of the pancreas, resection of the mid- portion of the pancreas and the mass with preserving the rim of the head and tail ... findings and surgical inter- ventions were analyzed. Results: The patients included 17 females and 1 male with a median age of 23 years. The median di...

Ngày tải lên: 25/10/2012, 11:40

... anahtar anahtar (the) key 6 anahtar + ımı anahtar + ımı my key (ACC.) 5 anahtarla anahtar + la with (the) key 4 anahtarı anahtar + ı 1 (the) key (ACC.); 2 his/her key 3 anahtarı + m anahtar + ım ... anahtarı + n anahtar + ın 1 your key; 2 of (the) key 1 anahtarı + nız anahtar + ınız your (pl.) key 1 anahtarı + nı anahtar + ını 1 your key (ACC.); 2 his/her key (ACC.) 1 anahtar + ınızı anaht...

Ngày tải lên: 20/02/2014, 04:20

... substituted by an alanine. The arabinanase activity of the mutants D3 8A, D17 1A and E22 4A was assayed in an Escherichia coli periplasmic fraction and compared to that of the wild-type (WT). Under these conditions, ... and de-branched arabinans, and heteropolysaccharides such as arabinoxylans and arabinogalactans. Arabinan is composed of a- 1,5-linked l-arabi...

Ngày tải lên: 15/03/2014, 23:20

... trun- cated (initial R-factor of 0.338, correlation coefficient of 0.720 for data between 2.8 and 20 A ˚ ). Further manual and automatic refinement of this and the other complexes was V. Helmetag et al. ... 2-ketogroup of aKG. The following oxidative decomposition of a- KG forms succinate and CO 2 and leads to the formation of an Fe(IV)-oxo species that abst...

Ngày tải lên: 16/03/2014, 02:20

... sentences are annotated in advance with semantic structures and are stored in a structured database. User requests are con- verted on the fly into patterns of these semantic annotations, and texts are ... and the UMLS meta-thesaurus 1 . Table 3 shows the size of the original database and the number of entries expanded by name varia- tions. Terms in MEDLINE were then...

Ngày tải lên: 17/03/2014, 04:20